DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC100149229

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333810.1	Gene:	LOC100149229 / 100149229	-ID:	-	Length:	335	Species:	Danio rerio

Alignment Length:	441	Identity:	91/441 - (20%)
Similarity:	145/441 - (32%)	Gaps:	138/441 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RAATTICNFFLIALVALS----STTLADESIDTRENADLTLKCRFNDKYEANDFSFFWTRWTANP 80
            |.|..:...||:.:..:|    ||......|...:|:.:|:.|.|...........||.:   |.
Zfish     6 RMAPALHLIFLLIIHRVSAAEWSTKYNATEICALQNSTMTISCTFTHPEGLQIMRAFWNK---NE 67

  Fly    81 AQFDNVAIGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHNLT 145
            .:.|    ||:.     .|...||   |..:::.:...:.|.....   :..|..|.|:.:..:|
Zfish    68 VKHD----GELT-----DLSEDPE---YSQRLQYLGDKQHNRTVRL---SHVTKKDEHEYYFRIT 117

  Fly   146 VLTPPHPPVISPG-NIAV----------ATEDKPMELTC-SSIGGSPDPTITWYREGSNTPLPAT 198
            ........:..|| .::|          .||...:.||| ||...:..||..|||...      |
Zfish   118 TNVSAQKWLGKPGVRLSVTDLQLESPERVTEGDSVRLTCKSSCKLTDTPTFIWYRNSH------T 176

  Fly   199 VLKGGTKDQPTNATLSIIPRREDDGAKYKCVVRNRA-MNEGKRLEATAT-LNVNYYPRVEVGPEN 261
            :...|.:       |:|......:...|.|.|:.:. ::....|:.|.. |:|           .
Zfish   177 LTNIGDE-------LNIRSVSRTEAGHYSCGVQGQMYISPAVYLDVTCKFLSV-----------L 223

  Fly   262 PLRVERDRTAKLECNVDA-----KPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADNG 321
            |..|...:|.:|..|:.|     .|..|.:       |:|.|.:
Zfish   224 PFSVYLFKTYRLTINMKAVELKNAPDTPVI-------FLSGSAI--------------------- 260

  Fly   322 LGKTGEQELILDILYPPMVVIESKTREAEEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDV 386
                                       .:|||:||:.|...:||..:...|.:||......:|.
Zfish   261 ---------------------------IKEGDSVTLMCISHSNPPALNFSWFEENQSSAVGSGQ- 297

  Fly   387 LTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYI 437
                |..|..:|.:.|.|.|   ..|.:||:.|   ||.       |:|:|
Zfish   298 ----SFSAVQSGRFYCEAHN---PHGAQRSDAV---TVT-------GEAFI 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	19/96 (20%)
		I-set	146..249	CDD:254352	25/116 (22%)
		Ig	168..249	CDD:299845	20/83 (24%)
		IGc2	268..323	CDD:197706	9/59 (15%)
		Ig_3	341..406	CDD:290638	17/64 (27%)
		Ig_2	437..514	CDD:290606	1/1 (100%)
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100149229	XP_021333810.1	Ig	40..136	CDD:325142	21/113 (19%)
		Ig_3	142..199	CDD:316449	17/69 (25%)
		Ig_2	251..326	CDD:316418	27/140 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010