DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and si:ch211-1f22.3

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333796.1	Gene:	si:ch211-1f22.3 / 100148240	ZFINID:	ZDB-GENE-121214-89	Length:	290	Species:	Danio rerio

Alignment Length:	328	Identity:	81/328 - (24%)
Similarity:	128/328 - (39%)	Gaps:	59/328 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VALSSTTLADESIDTR----ENADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVA-IGEVQL 93
            :.:||...|...|.:|    :|:.:.:.|.|...........|||:        |||. |....|
Zfish     1 MGVSSADWAVNYIHSRICALKNSSVIMSCTFTYPTRHQIKKVFWTK--------DNVKDIEPTDL 57

  Fly    94 SSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADVHQEFHNLTVLTPPHPPVISP 157
            |.      .||   |..:::.:...:.|    |.:: :..|..|.||.:.......|.......|
Zfish    58 SK------DPE---YSQRLQYLGDKQQN----CTVRLSHVTKKDEHQYYFRFITNVPNEKWTGKP 109

  Fly   158 G-NIAV----------ATEDKPMELTCSSIGGSPD-PTITWYREGSNTPLPATVLKGGTKDQPTN 210
            | :::|          .||...:.|||:|.....| ||..|||...      |:.:|.|.|:
Zfish   110 GVHLSVTDLQLESPERVTEGDSVRLTCNSSCKLTDTPTFIWYRNSH------TLTEGTTGDK--- 165

  Fly   211 ATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATAT-LNVNYYPR-VEVGPENPLRVERDRTAKL 273
              |.:|..||:...:|:|.|      :|..|.:... |||.|.|: |.|.......:....:..|
Zfish   166 --LILISFREEYAGRYRCAV------DGHTLTSPEVYLNVTYPPKSVSVTISGSAVIMSGDSVTL 222

  Fly   274 ECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQELILDILYPP 338
            .|:.|:.|.. .:.|.:...|:.|..:..|.::|..|:.||.|.|.|..|......:.|::....
Zfish   223 SCSSDSNPPA-EIHWFKGETFVGSGRILNISKISSDDSKKYKCKAKNDHGVKYSAAVTLNVQCEF 286

  Fly   339 MVV 341
            |:|
Zfish   287 MMV 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	21/98 (21%)
		I-set	146..249	CDD:254352	30/115 (26%)
		Ig	168..249	CDD:299845	24/82 (29%)
		IGc2	268..323	CDD:197706	15/54 (28%)
		Ig_3	341..406	CDD:290638	1/1 (100%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
si:ch211-1f22.3	XP_021333796.1	Ig	15..106	CDD:325142	23/111 (21%)
		IG	122..197	CDD:214652	26/91 (29%)
		Ig_2	211..282	CDD:316418	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920