DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC100147925

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333837.1	Gene:	LOC100147925 / 100147925	-ID:	-	Length:	364	Species:	Danio rerio

Alignment Length:	430	Identity:	95/430 - (22%)
Similarity:	157/430 - (36%)	Gaps:	134/430 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 PPVISPGNIAV--------ATEDKPMELTCS--SIGGSPDPTITWYREGSNTPLPATVLKG---- 202
            |.|.|.|..||        |.:|..:.::|:  ...|....|..|.:.......|..:.|.
Zfish    15 PDVFSEGEWAVHYSSSHICALKDSSVIMSCTYKYPAGHQIITAFWNKGFVKNGEPPDLSKDPEYS 79

  Fly   203 ------GTKDQPTNATLSIIPRRED-----------DGAKYKCVVRNRAMNEGKRLEATATLNVN 250
                  |.|.|.....||.:.:::.           .|.:|..:       .|.||..|
Zfish    80 QRLQYLGDKQQNCTIRLSHVTKKDKHEYYFRFITDVTGGRYTGI-------PGVRLSVT------ 131

  Fly   251 YYPRVEVGPENPLRV-ERDR---TAKLECNVDAKPKVPNVRWNRNGRFISSS------LVHTIHR 305
                 ::..|:|.|| |||.   |.|..||:   ...|...|.||.:.::..      :::::.|
Zfish   132 -----DLQLESPERVTERDSVRLTCKSSCNL---TDTPTFIWYRNSQRLTEGTTDNKLILNSVRR 188

  Fly   306 VSVQDAGKYTCIADNGLGKTGEQELILDILYPPMVVIESKTREAEEGDTVT-------IRCNVTA 363
               :|||:|.|                                |..|.|:|       :.|:..:
Zfish   189 ---EDAGRYRC--------------------------------AVHGHTLTSPDVYLDVTCDSDS 218

  Fly   364 NPAPVTIEWLK-ENSPDFRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERVGNSTVALL 427
            || |..|.|.| |.|..|   |.:.:::.:.:|.:|.|.|||.|   ..|.:.|:     .|.|.
Zfish   219 NP-PAEINWFKGETSVGF---GRIFSISKISSDDSGEYKCRATN---EHGGKHSD-----LVTLD 271

  Fly   428 VRHRPGQAYITPN-KPVVHVGNGVTLTC--SANPPGWPVPQYRWFRDMDGEFSSTQKILAQGPQY 489
            |::.|....::.| ..|:..|:.|:|.|  .:|||..   .:.||::      :....:..|..:
Zfish   272 VQYSPRSTSVSINGSAVIMSGDSVSLMCISDSNPPAL---NFSWFKE------NQSSAVGSGQSF 327

  Fly   490 SIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFL 529
            |..::     |:::|.|.|..|....|.:.:.:....|.|
Zfish   328 SAVQS-----GRFYCEAHNPHGAQRSAAVTVTVRGVYQHL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845
		I-set	146..249	CDD:254352	25/127 (20%)
		Ig	168..249	CDD:299845	17/103 (17%)
		IGc2	268..323	CDD:197706	15/63 (24%)
		Ig_3	341..406	CDD:290638	21/72 (29%)
		Ig_2	437..514	CDD:290606	18/79 (23%)
		I-set	526..633	CDD:254352	2/4 (50%)
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100147925	XP_021333837.1	Ig	30..111	CDD:325142	13/80 (16%)
		Ig_3	137..196	CDD:316449	19/64 (30%)
		Ig_2	209..272	CDD:316418	22/74 (30%)
		Ig_2	286..355	CDD:316418	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010