DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ed and zgc:172106

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001108035.2	Gene:	zgc:172106 / 100136844	ZFINID:	ZDB-GENE-080204-42	Length:	396	Species:	Danio rerio

Alignment Length:	411	Identity:	92/411 - (22%)
Similarity:	142/411 - (34%)	Gaps:	138/411 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CNFFLIALVALSSTTLADESIDTRENADLTLK---CRFNDKYEAND----FSFFWTRWTANPAQF 83
            |..|:|:|:.:.........:...:.|...||   .|.:..|:..|    ...|||
Zfish     3 CLSFIISLLMIPGICSQKWEVRYSKTAICVLKGSTMRLSGSYKHPDGLTVTEIFWT--------- 58

  Fly    84 DNVAIGE-VQL--SSGY--RLDFQPERGIYDLQIKNVSYNRDNGRFECRIKAKGTGADVHQEFHN 143
            .|:..|: :.|  :..|  |:|:.....::.|::.||.: .|.|.:..||:.|..    .|:|..
Zfish    59 VNIEKGKAINLLNNPNYTGRVDYFQIEEMFFLKLSNVRH-EDEGMYCIRIETKVE----KQQFLG 118

  Fly   144 LTVLTPPHPPVISPGNIAVATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQP 208
            .            ||          :|||.:.:               ....||.|::|   |.|
Zfish   119 F------------PG----------IELTVTDL---------------RVETPAEVVEG---DSP 143

  Fly   209 TNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPRVEVGPENPLRVERDRTAKL 273
            .                                                           .|.|.
Zfish   144 V-----------------------------------------------------------LTCKS 149

  Fly   274 ECNVDAKPKVPNVRWNRNGRFISSSLVHT---IHRVSVQDAGKYTCIADNGLGKTGEQELILDIL 335
            .||:.:...:    |.:||:..|.|:...   :..||.:|:|.|:| |...|.......|.|:|.
Zfish   150 SCNLGSTIFI----WYKNGKSFSESVRQNQLILQSVSSEDSGNYSC-AVRDLKDLPSPALTLNIR 209

  Fly   336 YPPMVVIESKTREA--EEGDTVTIRCNVTANPAPVTIEWLKENSPDFRYNGDVLTLTSVRADHAG 398
            |||..|..|.:..|  |.||:||:.|:..:||..|...|.|||......:|...:::|..:.|:|
Zfish   210 YPPKSVSVSVSGSAVIESGDSVTLSCSSDSNPPAVNFTWFKENQSSAVGSGQSFSISSFNSSHSG 274

  Fly   399 NYICRAVNIMQSQGMERSERV 419
            .|.|.|.|   ..|.:|||.|
Zfish   275 QYYCEAEN---KYGSQRSESV 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	25/108 (23%)
		I-set	146..249	CDD:254352	11/102 (11%)
		Ig	168..249	CDD:299845	9/80 (11%)
		IGc2	268..323	CDD:197706	16/57 (28%)
		Ig_3	341..406	CDD:290638	23/66 (35%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
zgc:172106	NP_001108035.2	IG_like	32..126	CDD:214653	28/129 (22%)
		Ig	32..110	CDD:299845	21/87 (24%)
		ig	131..195	CDD:278476	22/130 (17%)
		IG_like	136..195	CDD:214653	20/125 (16%)
		Ig_2	228..296	CDD:290606	25/68 (37%)
		IG_like	228..296	CDD:214653	25/68 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920