DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC100006752

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333405.1	Gene:	LOC100006752 / 100006752	-ID:	-	Length:	385	Species:	Danio rerio

Alignment Length:	354	Identity:	72/354 - (20%)
Similarity:	122/354 - (34%)	Gaps:	96/354 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LIALVALSSTTLADESID-------TRENADLTLKCRFNDKYEANDFSFFWTRWTANPAQFDNVA 87
            ||.|:.:...:.||..::       ..:::.:.:.|.:...........|||:.....|:|
Zfish    11 LIFLLMIHMVSSADWGVNYSSLHICAVKDSSVIISCTYKYPTVHQLMKVFWTKDPVKGAEF---- 71

  Fly    88 IGEVQLSSGYRLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADVHQEFHNL------- 144
               :.||.      .||   |..:::.:...:.|    |.:: :..|..|.|:.:..:
Zfish    72 ---LDLSE------DPE---YSQRLQYLGDKQQN----CTVRLSHVTEKDKHEYYFRIITDVREE 120

  Fly   145 -------TVLTPPHPPVISPGNIAVATEDKPMELTC-SSIGGSPDPTITWYREGSNTPLPATVLK 201
                   .:|:.....:.||..:   ||...:.||| ||...:..||..|||...      |:.|
Zfish   121 RWIGKPGVILSVTDLQLESPERV---TEGDSVHLTCRSSCNLTDTPTFIWYRNSH------TLTK 176

  Fly   202 GGTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATATLNVNYYPR---VEVGPENPL 263
            ....|:     |.:.|.|.:|..:|:|.|....:...:     ..|||.|.||   |.......|
Zfish   177 EMIGDK-----LILDPVRREDAGRYRCAVHGHTLTSPE-----VYLNVTYPPRNVSVSTNYSGQL 231

  Fly   264 RVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTCIADNGLGKTGEQ 328
            .:   .:..|.|..|:.|...:..|....:   ||.|.:....|...:|::.|.|.|..|
Zfish   232 WL---NSVSLMCISDSNPPALSFSWFEENQ---SSAVGSGQSFSAVQSGRFYCEAHNPHG----- 285

  Fly   329 ELILDILYPPMVVIESKTREAEEGDTVTI 357
                                |:..|.||:
Zfish   286 --------------------AQRSDAVTV 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	16/111 (14%)
		I-set	146..249	CDD:254352	26/103 (25%)
		Ig	168..249	CDD:299845	21/81 (26%)
		IGc2	268..323	CDD:197706	13/54 (24%)
		Ig_3	341..406	CDD:290638	4/17 (24%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100006752	XP_021333405.1	Ig	41..133	CDD:325142	17/111 (15%)
		Ig_3	139..198	CDD:316449	22/72 (31%)
		Ig	<183..215	CDD:325142	9/36 (25%)
		Ig_2	235..296	CDD:316418	18/88 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010