DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ed and LOC100006649

DIOPT Version :9

Sequence 1:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	XP_021333396.1	Gene:	LOC100006649 / 100006649	-ID:	-	Length:	507	Species:	Danio rerio

Alignment Length:	430	Identity:	106/430 - (24%)
Similarity:	175/430 - (40%)	Gaps:	69/430 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVNSRSARRAATTICNFFLIALVALSS--TTLADESIDTRENADLTLKCRFNDKYEANDFSFFWT 74
            :|...|.|.|...:. |.:|.:|:.:.  .....|.|...:::.:.:.|.:.........:.|||
Zfish     1 MVRMMSVRIALLPLI-FLMIHIVSSADWCVKYTPEHICALKSSTVIMSCTYKYPKSHKVRTAFWT 64

  Fly    75 RWTANPAQFDNVAIGEVQLSSGY-RLDFQPERGIYDLQIKNVSYNRDNGRFECRIK-AKGTGADV 137
            ::.....|             .| .|...||   |..:::.:...:.|    |.:: :..|..|.
Zfish    65 KYPPKQGQ-------------EYPDLSEDPE---YSQRLQYLGDKQQN----CHLRLSHVTKKDE 109

  Fly   138 HQEFHNLTVLTPPHPPVISPG-NIAV----------ATEDKPMELTC-SSIGGSPDPTITWYREG 190
            ||.:...|........:.:|| .::|          .||...:.||| ||...:..||..|||.
Zfish   110 HQYYFRFTTNVTGKMWLGTPGVRLSVTDLQLESPERVTEGDSVRLTCKSSCKLTDTPTFIWYRN- 173

  Fly   191 SNTPLPATVLKG--GTKDQPTNATLSIIPRREDDGAKYKCVVRNRAMNEGKRLEATAT-LNVNYY 252
                  :..|.|  |.|       |.:.|.|.:|..:|.|.|      :|..|.:... |||.|.
Zfish   174 ------SVTLTGKIGNK-------LILNPVRREDAGRYSCGV------DGHTLTSPEVYLNVTYP 219

  Fly   253 PR-VEVGPENPLRVERDRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGKYTC 316
            |: |.........:....:..|.|:.|:.|...|..|.:...|:.|..:..|.::|..|:|:|.|
Zfish   220 PKNVSASLNGSAVIMSGDSVTLSCSSDSNPPALNFSWYKGETFVGSGRIFNISKISSDDSGEYKC 284

  Fly   317 IADNGLGKTGEQELILDILYPPMVVIESKTREAE--EGDTVTIRCNVTANPAPVTIEWLKENSPD 379
            .|.|..|:.....:.||:.|.|..:..|....||  |||:||:.|:..:|| |..:.|.|.|..
Zfish   285 RARNKHGEKYSDPVTLDVQYSPKSISVSINGSAEIVEGDSVTLNCSSDSNP-PAELNWFKGNKS- 347

  Fly   380 FRYNGDVLTLTSVRADHAGNYICRAVNIMQSQGMERSERV 419
             ..:|.:..::.:.:|.:|.|.|:|.|   :.|::.|:.|
Zfish   348 -LNSGRLFNISKISSDDSGEYKCKAKN---AHGVKYSDPV 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ed	NP_001260013.1	Ig	50..147	CDD:299845	17/98 (17%)
		I-set	146..249	CDD:254352	29/117 (25%)
		Ig	168..249	CDD:299845	24/84 (29%)
		IGc2	268..323	CDD:197706	16/54 (30%)
		Ig_3	341..406	CDD:290638	21/66 (32%)
		Ig_2	437..514	CDD:290606
		I-set	526..633	CDD:254352
		Ig	546..632	CDD:143165
		IG_like	654..736	CDD:214653
		Ig	656..734	CDD:143165
		FN3	741..848	CDD:238020
LOC100006649	XP_021333396.1	Ig	33..116	CDD:325142	18/102 (18%)
		Ig_3	142..200	CDD:316449	21/71 (30%)
		Ig_2	230..302	CDD:316418	18/71 (25%)
		Ig_2	316..387	CDD:316418	24/74 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010