DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and FOL3

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_013831.1	Gene:	FOL3 / 855140	SGDID:	S000004719	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	436	Identity:	88/436 - (20%)
Similarity:	151/436 - (34%)	Gaps:	160/436 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 EHAGNYICRSVNIMQPFSSKRV------EGVGN-----STVALLVRHRPGQAYITPNKPVVHVGN 427
            ||.||          |.:|.||      .|.|:     |:|.....::.|: :.||:  :|||.:
Yeast    15 EHLGN----------PQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGK-FTTPH--LVHVTD 66

  Fly   428 GVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAH----------LGSEGKY- 481
            .:|:.      ..|:|..|:           |.|..|  ..::.|:|          ..:..||
Yeast    67 SITIN------NKPIPLERY-----------QNIRLQ--LEALNKSHSLKCTEFELLTCTAFKYF 112

  Fly   482 ---HCH-AVNELGIG-----------------KIATIILEVHQPPQFLAKLQQHMTRRVGDVDYA 525
               .|. .|.|:|:|                 .|..|.|: |:  .||......:::....:
Yeast   113 YDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLD-HE--SFLGNTLSEISKEKAGI--- 171

  Fly   526 VTCSAKGKPTPQIRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKA---------- 580
            :|   :|.|...|    |||                    ...:|.::::.|.||
Yeast   172 IT---EGVPFTVI----DGT--------------------NEASVINVVKERCKALGSELSVTDS 209

  Fly   581 RPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQA-- 643
            :.|||.:..|..|.:. |.:..:|......:||:....:...|.|:: .|:.:: ||..|:..
Yeast   210 QLNGNMIDTNSWGCFD-LAKLPLNGEYQIFNLRVAMGMLDYLQMNEL-IDITKN-EVSTRLAKVD 271

  Fly   644 YPKPEFQWQY-----GNNPSPLTMSSDGHYEISTRME---------NNDVYTSILRIAHLQHSDY 694
            :|...::..|     .|...|:.|  ||.:..|..:|         .|...|.::.:.|.::
Yeast   272 WPGRLYRMDYRFDKVSNRTVPILM--DGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKN--- 331

  Fly   695 GEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNW 740
                   :.||        |||.   .:|.:..||...:|...:.|
Yeast   332 -------LEPL--------LQPL---LRPIDQVILTRFNNVEGMPW 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653
		Ig	147..228	CDD:299845
		I-set	232..313	CDD:254352
		IGc2	250..302	CDD:197706
		IG_like	323..385	CDD:214653	4/10 (40%)
		IGc2	330..385	CDD:197706	4/10 (40%)
		Ig_2	416..501	CDD:290606	24/116 (21%)
		IG_like	418..501	CDD:214653	23/114 (20%)
		I-set	505..612	CDD:254352	20/116 (17%)
		Ig	526..611	CDD:143165	18/94 (19%)
		IG_like	633..715	CDD:214653	17/97 (18%)
		Ig	635..713	CDD:143165	17/93 (18%)
		FN3	720..838	CDD:238020	5/21 (24%)
FOL3	NP_013831.1	FolC	3..427	CDD:223362	88/436 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900