DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and KIRREL3

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	843	Identity:	190/843 - (22%)
Similarity:	317/843 - (37%)	Gaps:	205/843 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQI 91
            |..:.|.|...|:    |....|.:        :.:|:|   |:.....|.:......|.:.|:|
Human    68 GQPVTLLCAIPEY----DGFVLWIK--------DGLALGVGRDLSSYPQYLVVGNHLSGEHHLKI 120

  Fly    92 KNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIG 156
            ..... :|:..:||    :...|.:......||||..|..|::..|.:.......||.|||.:..
Human   121 LRAEL-QDDAVYEC----QAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADN 180

  Fly   157 GSPDPMITWYREGSTVPLQSYA---LKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGH 218
            ..|...|.|.|:|..:...:|:   |:.|.:.... :||.|.|...::|....|...|:|:|.|.
Human   181 AKPAASIIWLRKGEVINGATYSKTLLRDGKRESIV-STLFISPGDVENGQSIVCRATNKAIPGGK 244

  Fly   219 MLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIY 283
              |||||:::.:.|.|.:..: |..|..|:|....|...|.|.|:..||::.||.:... :..:|
Human   245 --ETSVTIDIQHPPLVNLSVE-PQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEA-SGEVY 305

  Fly   284 RVN---RHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPS 345
            |..   .:.:...:|...|.||.|.....| ||.:.|.:..|.::...:.|...:..|..|.|||
Human   306 RTTVDYTYFSEPVSCEVTNALGSTNLSRTV-DVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPS 369

  Fly   346 PINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHR 410
             :.:.|:|.|:.......:.|||.|||.|.||.|:||:|       ..|| |.|...|.|.| :.
Human   370 -LTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAV-------VPRV-GAGEREVTLTV-NG 424

  Fly   411 PGQAYITPNKPVVHVGNGVTLTC---SANPP---GWPVPQYRWFRDMDGDIGNTQKILAQGPQYS 469
            |.....|..:..:| |....:.|   |..||   .|     .|          .:.:|..
Human   425 PPIISSTQTQHALH-GEKGQIKCFIRSTPPPDRIAW-----SW----------KENVLES----- 468

  Fly   470 IPKAHLGSEGKYHCHAVN-ELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSA--- 530
                  |:.|:|....:: |.|:  |:|:.:             .::.|  .|......|:|
Human   469 ------GTSGRYTVETISTEEGV--ISTLTI-------------SNIVR--ADFQTIYNCTAWNS 510

  Fly   531 KGKPTPQIRWIKDGTEILPTRKMFDIRTTP------TDAGGGV---VAVQSILRF---------- 576
            .|..|..||..:.|:| :.:....:..:.|      ...|.||   |.:.:|:.|
Human   511 FGSDTEIIRLKEQGSE-MKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRSTG 574

  Fly   577 -------RG---KARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEH-EPI---------VI 621
                   ||   |||..    ||....|      ..|.||.:.:.:.|.| ||.         .|
Human   575 GRSGISGRGTEKKARLR----LPRRANL------KGVVSAKNDIRVEIVHKEPASGREGEEHSTI 629

  Fly   622 HQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRI 686
            .|......:.::.: |:.:::...:.|.::|...:|      ::|:|.::|..|::.  |..:.:
Human   630 KQLMMDRGEFQQDS-VLKQLEVLKEEEKEFQNLKDP------TNGYYSVNTFKEHHS--TPTISL 685

  Fly   687 AHLQHSDYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVL-------NWTPGF 744
            :..|..                     |:|.|....||.:....:   |:.|       ::...|
Human   686 SSCQPD---------------------LRPAGKQRVPTGMSFTNI---YSTLSGQGRLYDYGQRF 726

  Fly   745 NGGFMSTKYLVSYRRVATPREQTLSDCSG----------------NGYIPSYQISSSSSNSNH 791
            ..|..|:...:..|..   :..:|||.|.                :||:...:.|.:|::|:|
Human   727 VLGMGSSSIELCEREF---QRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSH 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	19/98 (19%)
		IG_like	141..228	CDD:214653	28/89 (31%)
		Ig	147..228	CDD:299845	28/83 (34%)
		I-set	232..313	CDD:254352	22/83 (27%)
		IGc2	250..302	CDD:197706	12/54 (22%)
		IG_like	323..385	CDD:214653	21/61 (34%)
		IGc2	330..385	CDD:197706	21/54 (39%)
		Ig_2	416..501	CDD:290606	17/91 (19%)
		IG_like	418..501	CDD:214653	16/89 (18%)
		I-set	505..612	CDD:254352	28/138 (20%)
		Ig	526..611	CDD:143165	26/116 (22%)
		IG_like	633..715	CDD:214653	10/81 (12%)
		Ig	635..713	CDD:143165	10/77 (13%)
		FN3	720..838	CDD:238020	18/95 (19%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	18/97 (19%)
		IG_like	60..149	CDD:214653	18/97 (19%)
		I-set	156..249	CDD:254352	28/95 (29%)
		Ig2_KIRREL3-like	171..252	CDD:143236	28/83 (34%)
		Ig_2	260..337	CDD:290606	20/79 (25%)
		I-set	341..422	CDD:254352	30/89 (34%)
		IGc2	355..406	CDD:197706	20/51 (39%)
		Ig5_KIRREL3	424..521	CDD:143306	26/140 (19%)
		IG_like	432..521	CDD:214653	24/132 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840