DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and KIRREL2

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	747	Identity:	160/747 - (21%)
Similarity:	242/747 - (32%)	Gaps:	231/747 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YW--ARWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAK 110
            ||  .:||     ...:|:|   |:...|.|.:....:.|.:||.|:.... .|...:||    :
Human    50 YWGLVQWT-----KSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVEL-EDEASYEC----Q 104

  Fly   111 GTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGS-PDPMITWYREGSTVPL 174
            .|.|.:......|.||..|..|.|..|.........|..|||.|.|.: |.|.:.|:|:|
Human   105 ATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDG----- 164

  Fly   175 QSYALKGGSKNHYT----------NATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVN 229
               .|..|:..|.|          .:||.:.|...||||.:.|...::|:|.|.  :|::||::.
Human   165 ---VLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGR--DTAITLSLQ 224

  Fly   230 YYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYV--SATPTHTIYRVNRHHAGK 292
            |.|.|.:. .:|..|:........|:..|:|.|:..||::.|..|  :..|...:..........
Human   225 YPPEVTLS-ASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEP 288

  Fly   293 YTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAP 357
            .:|...|.:| :..:...||||:.||:..:.:....:.||.....|....||.| .|.|.:.|..
Human   289 VSCEVSNAVG-SANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLP-RVTWTRRGGA 351

  Fly   358 DFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPV 422
            ....:|..|.|.||..|.||:|:||:           ..|:..      :|....:|.:|.|.|
Human   352 QVLGSGATLRLPSVGPEDAGDYVCRA-----------EAGLSG------LRGGAAEARLTVNAP- 398

  Fly   423 VHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVN 487

Human   399 ----------------------------------------------------------------- 398

  Fly   488 ELGIGKIATIILEVHQPPQFL---AKLQQHMTRRVGDVDYAVTCSAKGKPTPQ-IRW------IK 542
                    .::..:|..|.||   |:||               |.....|.|. :.|      ::
Human   399 --------PVVTALHSAPAFLRGPARLQ---------------CLVFASPAPDAVVWSWDEGFLE 440

  Fly   543 DGTEILPTRKMFDIRTTPTDAGG---GVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDV- 603
            .|::   .|.:.:....|...||   |:::|..|         :|.|.....|. :.|...|.:
Human   441 AGSQ---GRFLVETFPAPESRGGLGPGLISVLHI---------SGTQESDFSRS-FNCSARNRLG 492

  Fly   604 -NSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQA------------------YPKPEF 649
             ..|.:|:..|                ||..:..:|..|.|                  :.|...
Human   493 EGGAQASLGRR----------------DLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASA 541

  Fly   650 QWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDY---------------GEYIC 699
            .:....|...:..||||........|..........|.|..|||.               |.|..
Human   542 SFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEEGTLETKDPTNGYYKV 606

  Fly   700 RAVNPLDSI-RAP---IRL---QPKGSPEKPT 724
            |.|:...|: .||   :.|   .|.|.|..||
Human   607 RGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPT 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	19/79 (24%)
		IG_like	141..228	CDD:214653	29/97 (30%)
		Ig	147..228	CDD:299845	29/91 (32%)
		I-set	232..313	CDD:254352	17/82 (21%)
		IGc2	250..302	CDD:197706	11/53 (21%)
		IG_like	323..385	CDD:214653	20/61 (33%)
		IGc2	330..385	CDD:197706	20/54 (37%)
		Ig_2	416..501	CDD:290606	3/84 (4%)
		IG_like	418..501	CDD:214653	2/82 (2%)
		I-set	505..612	CDD:254352	25/121 (21%)
		Ig	526..611	CDD:143165	19/96 (20%)
		IG_like	633..715	CDD:214653	23/121 (19%)
		Ig	635..713	CDD:143165	22/114 (19%)
		FN3	720..838	CDD:238020	3/5 (60%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	19/78 (24%)
		IGc2	38..106	CDD:197706	16/65 (25%)
		I-set	126..224	CDD:254352	32/107 (30%)
		Ig2_KIRREL3-like	141..223	CDD:143236	29/91 (32%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	14/76 (18%)
		IG_like	234..308	CDD:214653	15/74 (20%)
		Ig	312..395	CDD:299845	25/100 (25%)
		I-set	317..395	CDD:254352	23/95 (24%)
		Ig	397..501	CDD:299845	27/205 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		11/55 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840