DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fred and nphs1

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:NP_001035777.1 Gene:nphs1 / 692352 ZFINID:ZDB-GENE-051102-1 Length:1242 Species:Danio rerio


Alignment Length:1376 Identity:265/1376 - (19%)
Similarity:431/1376 - (31%) Gaps:545/1376 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 WLSIGLISG--------------------DDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTC 57
            |||:...||                    ..::..|.|...:|||....                
Zfish     4 WLSLVFSSGCFLLLVDFKGVCGQQAFKTEPRNVTVRAGATALLKCEVLR---------------- 52

  Fly    58 CPTLFENVAIGDVQ----------LNS-----NYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRI 107
                    |.|.||          |.|     .|.:.....:|.|.|||.:.:. .|:|.:||::
Zfish    53 --------ASGAVQWVKDGLLLRPLRSLPGYPRYSMTGDQKKGQYHLQILDVTL-EDDGPYECQV 108

  Fly   108 KAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLE-----LTCSSIGGSPDPMITWYR 167
            ....:...:......|.|......|.     ..:.:||..:|     :||.:....|...||.:|
Zfish   109 GRSESSRPIVSRTVWLNVQIPSSQPY-----FQLESEEPWVEGEQYTVTCIAPDAKPPAEITIFR 168

  Fly   168 EG-STVPLQSYALKGG-SKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNY 230
            :| ..:..:||.:.|. .|...|:|.:.|..|.:||..:..|...|.|.|..  |||.:|:.| |
Zfish   169 DGEELLESESYTMSGSQDKLQNTHAEVTIRARSSDDTRRLTCRAKNPASPRA--LETGMTMKV-Y 230

  Fly   231 YPRVEVGPQNPL-------KVERDHVAKLDCRVDAKPMVSNVRWSRNGQ---------YVSATPT 279
            :|     ||.|:       :|:.....|:.|.......::.:.|::||:         :||...:
Zfish   231 FP-----PQAPMIMGLENEEVKAGSFLKVVCMSYGGNPLATLHWTKNGEVLSTSWDVDFVSRRAS 290

  Fly   280 HTI---YRVNRHHAGKYTCSADN-------GLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETV 334
            ..:   .:...:|| ...|.:.|       .|.:|      |.|.:.|.......:.||.|||.:
Zfish   291 SVLKMEVKPEDNHA-VLQCQSINQVTRSPMSLTRT------LTVPFEPAEVTLLGSFEAVEGEEI 348

  Fly   335 LIRCNVTANPSPINVEW-------------LKEGAPDFRYTGELLTLGSV-----RAEHAGNYIC 381
            .:.|:.:::..|:::.|             ..||.     .|.::|:.::     |.::..:..|
Zfish   349 NLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGD-----NGGMMTVSNLTHKVSREDNGLSLQC 408

  Fly   382 RSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVV--HVGNGVTLTC---SANPPGWP 441
            .:.|....|||.|       ...|:|.:.|.:.::....|.|  |.|:.:.|.|   ..||.|  
Zfish   409 EAFNKGTRFSSVR-------AAELIVYYPPQKVWLDAPPPNVFLHSGSTLRLVCFSSGGNPTG-- 464

  Fly   442 VPQYRWFR--------------------------------------------------------- 449
              |..|.:                                                         
Zfish   465 --QLTWLKNNKVVLTASKQVSSERGVSRELLLTLHPSDNLATYRCDSSNKAKKVLSAQTKFRVLF 527

  Fly   450 --------------------DMDGDIGNTQ----------KILAQGPQYSIPKAHLGSEGK---- 480
                                |:|...|::.          .::.:|...:..:|..|...:    
Zfish   528 PAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSLGPVILKGVDQAPKRAEFGGMSRTSKL 592

  Fly   481 ------YH------CHAV-NELGIGKIATIILEVHQPPQFLA----------------------- 509
                  :|      |.|. |.|..|......|:|..||:|.|                       
Zfish   593 SLTLEPHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSAEQPDEVQVIEDETATLPAKVSAN 657

  Fly   510 -------------KLQQ----------------HMTRRVGDVDYAVTCS-AKG----------KP 534
                         ||.:                :::||.|. ||.:.|| |:|          :.
Zfish   658 PDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVNVSRRDGG-DYIIECSNAEGSNRTKLRLDVQY 721

  Fly   535 TPQIRW--------IKDGTEIL------P-TRKMF-----------DIRTTPTDAGGGVVAVQSI 573
            :|.:|.        |.|..::|      | |..||           ::.....|.|.||:.:..:
Zfish   722 SPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGEGERDELGEESEDDGTGVLTIYEV 786

  Fly   574 LRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIH--------QYNKVAY- 629
            .|.|.              |:|.|..:|.::...|     :|.:.||..        |:.|||. 
Zfish   787 TRDRA--------------GVYQCTADNGISPTGS-----VEGQLIVRFAPDLQKGPQWRKVASR 832

  Fly   630 -DLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHS- 692
             |....|.|||:.|..|:.:|:|  ..|..||.:.:. .||.:|. ....::||||.:.::..: 
Zfish   833 GDGSNDANVVCQAQGVPRVQFRW--AKNGFPLDLGNP-RYEETTE-STGTIHTSILTVINVSAAL 893

  Fly   693 DYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSY 757
            ||..:.|.|.|.:......|:|.....|:.|::||:|.|......|.|.|||:||      |...
Zfish   894 DYAIFTCTAHNSMGEDSLDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGG------LTQI 952

  Fly   758 RRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPC--KLAPLDQHQSYMFKVY 820
            .||                  .||.:.|:|     ::..:.|.....  .:..|:....|.|.|.
Zfish   953 FRV------------------RYQWAGSAS-----YMYVDVFPPTATVYTVTGLNPSTMYNFSVN 994

  Fly   821 ALNSKGTSGY--SNEILATTKVSKIPPPLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATV 883
            ||||.|.|.|  :|:||..|                                       |.||  
Zfish   995 ALNSIGESSYADNNKILTVT---------------------------------------TADA-- 1018

  Fly   884 PMWEIVETLTLLPSGSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMALAETAG 948
                                |||                      .||.|...:|..:     ||
Zfish  1019 --------------------KEA----------------------DGGVSTADQDSAL-----AG 1036

  Fly   949 PGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLGLLYAFCHC 1013
            .|..|.|                                  :|.:::..:.|::...:.:.....
Zfish  1037 GGLPVYV----------------------------------VVILVVGGVLFLLNPFICFLLARW 1067

  Fly  1014 RRKHAAKKESSSVGGGVGGGNANATANPGS--------TGAKEYDLDLDASRRPSLSQDPQQSQQ 1070
            :|:.:.|..:||:..........:||:..:        ..:.:..|.:|:|..|..|......:|
Zfish  1068 KRRRSLKGNTSSISQETKSEEQRSTASSSTRYASRELINASAQRTLLVDSSSEPDSSVYESYGRQ 1132

  Fly  1071 QPPPPPPYYPT 1081
            :  .|..||||
Zfish  1133 E--NPHYYYPT 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 21/111 (19%)
IG_like 141..228 CDD:214653 28/93 (30%)
Ig 147..228 CDD:299845 26/87 (30%)
I-set 232..313 CDD:254352 19/106 (18%)
IGc2 250..302 CDD:197706 11/70 (16%)
IG_like 323..385 CDD:214653 14/79 (18%)
IGc2 330..385 CDD:197706 12/72 (17%)
Ig_2 416..501 CDD:290606 24/193 (12%)
IG_like 418..501 CDD:214653 24/191 (13%)
I-set 505..612 CDD:254352 34/195 (17%)
Ig 526..611 CDD:143165 24/121 (20%)
IG_like 633..715 CDD:214653 24/82 (29%)
Ig 635..713 CDD:143165 23/78 (29%)
FN3 720..838 CDD:238020 35/121 (29%)
nphs1NP_001035777.1 IG_like 33..126 CDD:214653 22/117 (19%)
Ig 133..216 CDD:386229 23/87 (26%)
Ig 261..313 CDD:386229 8/52 (15%)
Ig 333..419 CDD:386229 16/90 (18%)
ig 439..511 CDD:365836 11/75 (15%)
IG_like 637..719 CDD:214653 11/82 (13%)
Ig_3 723..800 CDD:372822 18/90 (20%)
Ig_hNephrin_like 814..922 CDD:143250 31/111 (28%)
FN3 921..1012 CDD:238020 34/119 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.910

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