DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and Nphs1

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	1006	Identity:	227/1006 - (22%)
Similarity:	366/1006 - (36%)	Gaps:	266/1006 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIIGQLWLSIGLISGDDSLDTRE---------GVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLF 62
            |:..::.||| |:|....|.|.|         |.:.|:.|...:...:.|.||..:..|
  Rat   136 LVSPKVILSI-LVSPKVLLLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRT------ 193

  Fly    63 ENVAIGDVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGR----------FECRIKAKGTGADVH 117
                |.||..|.|...:.:..  |.:.:.:....:.|||:          .:..|||.
  Rat   194 ----ILDVSSNVNEGSEEKLC--ITEAEARVIPQSSDNGQLLVCEGSNPALDTPIKAS------- 245

  Fly   118 QEFYNLTVLTAPHPPMVT-PG-NLAVATEEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYALK 180
               :.:.:|..|.||::. || |.......:.|||.|::.||:|...:.|.:.|..|   |.|..
  Rat   246 ---FTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCTARGGNPPATLQWLKNGKPV---STAWG 304

  Fly   181 GGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVE 245
            ........::.|.:..|..|.||:..|..:| ::..|.. |.|:||.|.:.|.......:..:.|
  Rat   305 TEHAQAVAHSVLVMTVRPEDHGARLSCQSYN-SVSAGTQ-ERSITLQVTFPPSAITILGSVSQSE 367

  Fly   246 RDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCS--------ADNGLG 302
            ..:|........::|.|. :||...|:.:..| ..|:  ::..|.|..:.|        .||||.
  Rat   368 NKNVTLCCLTKSSRPRVL-LRWWLGGRQLLPT-DETV--MDGLHGGHISMSNLTFLVRREDNGLP 428

  Fly   303 KTGE------------KDIVLDVLYP-PIVFIESKTHEAEEGETV-------LIRCNVTANPSPI 347
            .|.|            |.:.|:|.|| ..::||.    ..||:.:       |:...:..||.|
  Rat   429 LTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEG----PPEGQYIRTGTRVRLVCLAIGGNPDP- 488

  Fly   348 NVEWLKEGAP--DFRYTGE--LLTLGSVRAEHAGNYICRS-VNIMQP------FSSKRVEGVGNS 401
            ::.|.|:..|  :.|...|  .:.||||  |.:|:...|. |.|:.|      ||.|  .|..::
  Rat   489 SLIWFKDSRPVSEPRQPQEPRRVQLGSV--EKSGSTFSRELVLIIGPPDNRAKFSCK--AGQLSA 549

  Fly   402 TVALLVRHRPGQAYITPNKPVVHVGNGVTLTC---SANPPGWPVPQYRWFRDMDGDIGNTQKILA 463
            :..|:|:..|....|..|...:..|:.:.|||   |:|||    ....|.::     |...:.:|
  Rat   550 STQLVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPP----VNLSWDKE-----GERLEDVA 605

  Fly   464 QGPQYSIPKAHLGSEGKY-------H-----CHAVNELGIGKIATII-LEVHQPPQFLAKLQQHM 515
            ..||.:..|....|...:       |     |.|.:|.....:::.. ..|..||:||.:..:.:
  Rat   606 AKPQSAPFKGSAASRSVFLRVSSRDHGQRVTCRAHSEALRETVSSFYRFNVLYPPEFLGEQVRAV 670

  Fly   516 T-RRVGDVDYAVTCSAKGKPTPQ-IRWIKDGTEILP-------------------TRK------- 552
            | ...|.|...|:.||  .|.|: ..|...|..:.|                   ||.
  Rat   671 TVVEQGQVLLPVSVSA--NPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQL 733

  Fly   553 -------------MFDIRTTPT----------DAGGGVVAVQSILRFRGKARPNGNQLLP----- 589
                         ..|:...||          :.||.|..|.::         :.|.:||
  Rat   734 HCQNSEGTAEALLKLDVHYAPTIRALRDPTEVNVGGSVDIVCTV---------DANPILPEMFSW 789

  Fly   590 ---------------------------------NDRGLYTCLYENDV-NSANSSMHLRIEHEPIV 620
                                             :..|.|.|:.:|.| .:|...:.|.:...|.|
  Rat   790 ERLGEEEEDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQV 854

  Fly   621 IH--QYNKVAY--DLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYT 681
            ..  ...|||.  |...||.:.||.:..|..:|.|.  .|..||.:....:.|  .|.....|::
  Rat   855 DQPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWT--KNGVPLDLQDPRYTE--HRYHQGVVHS 915

  Fly   682 SILRIAHLQHS-DYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFN 745
            |:|.||::..: ||..:.|.|.|.|.|....|:|.....|:.|..||::.:..:...|.|.|||:
  Rat   916 SLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSISPHSVGLEWKPGFD 980

  Fly   746 GGFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLD 810
            || :..::.:.|..:.||           |::....:.:.::...               |..|.
  Rat   981 GG-LPQRFQIRYEALETP-----------GFLHVDVLPTQATTFT---------------LTGLK 1018

  Fly   811 QHQSYMFKVYALNSKGTSGYSN---EILATT 838
            ....|...:.|.|:.|.||.::   ::..||
  Rat  1019 PSTRYRIWLLASNALGDSGLTDKGIQVSVTT 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	20/115 (17%)
		IG_like	141..228	CDD:214653	24/86 (28%)
		Ig	147..228	CDD:299845	24/80 (30%)
		I-set	232..313	CDD:254352	21/100 (21%)
		IGc2	250..302	CDD:197706	13/59 (22%)
		IG_like	323..385	CDD:214653	18/73 (25%)
		IGc2	330..385	CDD:197706	18/66 (27%)
		Ig_2	416..501	CDD:290606	21/100 (21%)
		IG_like	418..501	CDD:214653	20/98 (20%)
		I-set	505..612	CDD:254352	32/196 (16%)
		Ig	526..611	CDD:143165	26/173 (15%)
		IG_like	633..715	CDD:214653	25/82 (30%)
		Ig	635..713	CDD:143165	23/78 (29%)
		FN3	720..838	CDD:238020	23/120 (19%)
Nphs1	NP_072150.1	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423	18/98 (18%)
		Ig_3	256..335	CDD:290638	23/81 (28%)
		IG_like	268..350	CDD:214653	24/86 (28%)
		C2-set_2	358..440	CDD:285423	18/85 (21%)
		I-set	460..555	CDD:254352	28/103 (27%)
		Ig	472..555	CDD:299845	24/87 (28%)
		Ig	563..646	CDD:299845	21/91 (23%)
		IG_like	670..750	CDD:214653	13/81 (16%)
		Ig	676..750	CDD:299845	12/75 (16%)
		Ig_3	753..834	CDD:290638	12/89 (13%)
		IG_like	762..848	CDD:214653	14/94 (15%)
		Ig	848..956	CDD:299845	32/111 (29%)
		IG_like	859..949	CDD:214653	29/93 (31%)
		FN3	955..1049	CDD:238020	23/120 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910