DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and kirrel3a

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_700618.5	Gene:	kirrel3a / 571887	ZFINID:	ZDB-GENE-091117-44	Length:	774	Species:	Danio rerio

Alignment Length:	873	Identity:	194/873 - (22%)
Similarity:	315/873 - (36%)	Gaps:	244/873 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TIKLLIIGQ----LWLSIGLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFE 63
            |:...|||.    ||:..||..|.:              |....|...|
Zfish    39 TLPCTIIGYQGMVLWVKDGLALGVN--------------RDLSGYPRYD---------------- 73

  Fly    64 NVAIGDVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECR-IKAKGTGADVHQEFYNLTVLT 127
              .|||            .|:|.|.|.|:.|.. .|:|.|||: |:..|.....     .||||.
Zfish    74 --VIGD------------HSKGEYHLLIERTEL-VDDGSFECQAIQVAGRSRPA-----QLTVLV 118

  Fly   128 APHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYA---LKGGSKNHYTN 189
            .|..|::....:........|.|||.:....|...|.|.|.|..:...:|.   |:.| |...|.
Zfish   119 PPDDPVIIGAPVVSLRAGDSLNLTCHANNAKPAASIIWIRNGEVINGAAYTKTLLRDG-KRESTV 182

  Fly   190 ATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDC 254
            :||.|.....:.|.:..|...|:|.|.|.  |.:||:::.::|.|.:..: |..|...::.|..|
Zfish   183 STLHISASNIESGQQITCRASNKAAPNGK--EATVTIDIQHFPLVNLSVE-PQPVLEGNLVKFHC 244

  Fly   255 RVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHA---GKYTCSADNGLGKTGEKDIVLDVLYP 316
            ...|.|.|::.||::.|..:: ..|...|.|...|:   ...:|...|.||.|.....| ||.:.
Zfish   245 AAKANPPVTHYRWAKGGSMIT-DATGDTYEVLVDHSFFTEPVSCEVTNALGSTNISRNV-DVYFG 307

  Fly   317 PIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYIC 381
            |.:..|.::.:.:.|...:..|....||| :.:.|:|.|..........|||.:||.|.||.|:|
Zfish   308 PRLAAEPQSLQVDRGSDAVFSCAWIGNPS-LTIVWMKRGHGVVLSNENTLTLKAVRQEDAGKYVC 371

  Fly   382 RSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTC---SANPP---GW 440
            |:|       ..|| |||...|.|.| :.|.....|..:..:: |....:.|   |..||   .|
Zfish   372 RAV-------VPRV-GVGEKEVMLTV-NGPPSISSTQTQQALY-GEKGQIKCFIRSTPPPDRIAW 426

  Fly   441 PVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVN-ELGIGKIATIILEVHQP 504
                 .|          .:.:|..           |:.|:|....|: |.|:  |:|:.:
Zfish   427 -----SW----------KETVLES-----------GTSGRYTVETVSTEEGV--ISTLTM----- 458

  Fly   505 PQFLAKLQQHMTRRVGDVDYAV--TCSAKGKPTPQIRWIKDG--TEILPTRKMFDIRTTPTDAGG 565
                        |.:...|:..  .|:|         |...|  |||:..::...:|.. ...|.
Zfish   459 ------------RNIVPTDFQTIYNCTA---------WNSFGSDTEIIRLKEQGSLRLA-VIIGV 501

  Fly   566 GVVAVQSILRFRGKARPNGNQLLPNDRGLYTC--LYENDVN------------------------ 604
            .|.|..:::            :|....|.:.|  |...|::
Zfish   502 AVGAFLALI------------VLIGTLGAFCCARLQRKDMHLVMSSLPVSLSSRQREISGTVKSE 554

  Fly   605 ------SANSSMHLRIEH-------EPIVIHQYNKVAYDLRESAE-----VVCRVQAYPKPEFQW 651
                  ||.:.:.:.|.|       ||   .:::.|...:.|.|:     |:.:::...:.|.:.
Zfish   555 NLKGVVSAKNDIRVEIVHKDHNAAREP---EEHSNVKQMMMERADFQQESVLKQLEVLQEEEREL 616

  Fly   652 QYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICRAVNPLDSIRAPIRLQP 716
            |:..:|      ::|:|.::|..|..   |..:.:...|:::       ..||..:.....|: |
Zfish   617 QHIKDP------TNGYYSVNTFKEQP---TPTISLTANQNAE-------VRNPATATLGKHRV-P 664

  Fly   717 KGSPEKPTNL-KILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSG------- 773
            .|.  ..||: ..|..|.| .:.:::..|..|..|:...:..|..   :..:|||.|.
Zfish   665 TGM--SYTNIYNTLGAGPN-RLYDYSQRFVLGMGSSSIELCEREF---QRGSLSDSSSFQDTQCD 723

  Fly   774 ---------NGYIPSYQISSSS-SNSNH 791
                     :||:...:.|.:| |:|:|
Zfish   724 SSVSSYSKQDGYVQFDKASKASVSSSSH 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	21/97 (22%)
		IG_like	141..228	CDD:214653	26/89 (29%)
		Ig	147..228	CDD:299845	26/83 (31%)
		I-set	232..313	CDD:254352	22/83 (27%)
		IGc2	250..302	CDD:197706	14/54 (26%)
		IG_like	323..385	CDD:214653	19/61 (31%)
		IGc2	330..385	CDD:197706	19/54 (35%)
		Ig_2	416..501	CDD:290606	17/91 (19%)
		IG_like	418..501	CDD:214653	16/89 (18%)
		I-set	505..612	CDD:254352	20/142 (14%)
		Ig	526..611	CDD:143165	18/120 (15%)
		IG_like	633..715	CDD:214653	15/86 (17%)
		Ig	635..713	CDD:143165	13/82 (16%)
		FN3	720..838	CDD:238020	20/90 (22%)
kirrel3a	XP_700618.5	Ig	25..116	CDD:299845	29/126 (23%)
		IG_like	27..116	CDD:214653	29/126 (23%)
		I-set	123..217	CDD:254352	26/96 (27%)
		Ig2_KIRREL3-like	139..219	CDD:143236	26/82 (32%)
		Ig_2	227..304	CDD:290606	20/79 (25%)
		I-set	308..389	CDD:254352	29/89 (33%)
		IGc2	322..373	CDD:197706	18/51 (35%)
		Ig5_KIRREL3	391..488	CDD:143306	27/151 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582415
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840