DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and si:dkey-24p1.1

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001091715.1	Gene:	si:dkey-24p1.1 / 556718	ZFINID:	ZDB-GENE-060503-631	Length:	1043	Species:	Danio rerio

Alignment Length:	1328	Identity:	244/1328 - (18%)
Similarity:	406/1328 - (30%)	Gaps:	454/1328 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVH---QEFYNLTVLTAPHPP 132
            |..:..:.|.|    |.|||      ..|:|.:..|.    .|.|.|   .:..||||...|...
Zfish   109 QTINEMQCDLR----ITDLQ------KTDSGNYSFRY----IGPDPHIFMSKAMNLTVTDNPCKV 159

  Fly   133 MVTPGNLAVATEEKPLE------LTCSSIGGSPDPMITW--YREGSTVPLQSYALKGGSKNHYTN 189
            .:.|..|     :.||:      :.|.:.|....|. .|  ::.|.|
Zfish   160 YIEPSEL-----KNPLKESDKFTVQCFTSGPCDSPP-EWLLFKSGQT------------------ 200

  Fly   190 ATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDC 254
                  |.            |..:..:..::||.         :.|.|.|         |.||..
Zfish   201 ------PE------------WTSSPSKEMIIETE---------KGENGTQ---------VTKLKL 229

  Fly   255 RVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIV 319
                     .|.|..:.:.:|..|.::          ..:|...|         |.|.|.|.|
Zfish   230 ---------TVTWKDDNRILSCRPANS----------DDSCQIRN---------ITLSVEYSP-- 264

  Fly   320 FIESKTH------EAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGN 378
               .:||      :.:|..:|.:.|.....|. :...|.|:.....:...: |.|..::.|.:|.
Zfish   265 ---KETHASVSSNDVKETNSVTLSCTSRGRPE-VTYTWFKKNKGKLQQISD-LDLRQMKPEDSGE 324

  Fly   379 YICRSVNIMQPFSSKRVEGVGNST-VALLVRHRPGQAYITP--NKPVVHVGNGVTLTCSANPPGW 440
            |.|.:.|.:         ||..|. :::.|:..|....:||  |...:..|:.|||.||......
Zfish   325 YYCEAKNSL---------GVMKSNEISINVKFGPKGVTVTPPYNINDIKEGDTVTLKCSVERQNP 380

  Fly   441 PVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKIATIILEVHQPP 505
            |..::.|:::        .:|..:..:..|.:....:..||.|.|.|.:..|:...:.:.|...|
Zfish   381 PASRFVWYKN--------NRIQQETSETFIDRKVTAAVQKYKCEANNGINKGQSQELTVNVKYSP 437

  Fly   506 QFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRW-IKDGTEILPTRKMFDIRTTPTDAGGGVVA 569
            :.: .:|...:.:||. ...:||||...|.|..:| ...|....|..| ..:.|.|       |.
Zfish   438 RNI-NIQGKTSVKVGS-RLELTCSADAHPQPVYKWTFPPGLSFSPLSK-GKLETQP-------VT 492

  Fly   570 VQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYNKVAYDLRES 634
            ::                   ..|.|||...|.:.:.:.|.::::.:.|..|:...:......|.
Zfish   493 IE-------------------HAGEYTCGVTNTIGTKSESTNVKVLYPPRNINLMMQSEVREFEV 538

  Fly   635 AEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVY-TSILRIAHLQHSDYGEYI 698
            ..|:|.||::|..:|         .:|.:.|....|.....|:..| ..::...::..||.|.|.
Zfish   539 ISVICTVQSFPTSKF---------TVTKNLDNLLNIPECRRNSTEYENKVIIFLNVTESDAGTYK 594

  Fly   699 CRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATP 763
            |.|.|            .:|..|....|.:|     ||..|.|..|.|...|..
Zfish   595 CTAKN------------TEGQEETNKKLTVL-----YAPKNVTASFKGDQKSAS----------- 631

  Fly   764 REQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKG-- 826
             |.||: |         :..|:...|::||.     |.|..:...|.|||...|....::..|
Zfish   632 -ELTLT-C---------EACSNPPVSSYEWT-----KLNNGQFETLKQHQQLHFNSLEISDSGQY 680

  Fly   827 -TSGYSNEILATTKVSKIPPPLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATVPMWEIVE 890
             ...|:    |..|....|..:.|.|.||               |.:|.:..|.    ..|.:..
Zfish   681 VCIAYN----AIGKAKSPPLDIRVKYTPN---------------ITIVHNTTTS----AQWNLPV 722

  Fly   891 TLTLL----PSGSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMALAE------ 945
            .|:.:    |..:|..:                              :..||.|..|::
Zfish   723 YLSCIADAHPPATEYKW------------------------------YRQEDNTTVLSQQQNFTV 757

  Fly   946 -TAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLGLLYA 1009
             ...||    :..|..:|          :||.|.....:...:::|...:...|..:..|.|:..
Zfish   758 LPQNPG----LYYCTATN----------DIGLSRSKQIALFVSTSLSVFLKIVLPIIFLLVLIVV 808

  Fly  1010 FCHCRRKHAAKKESSSVGGG---------------------VGGGNANATANPGSTGAKEYDLDL 1053
            .....|::..|..|....|.                     :.|...|...|..........::|
Zfish   809 VIFLIRRNIIKIRSDQQSGADNLLCLFPAFLSRSSRVQNLFLLGSRNNTQENLSLDDPNYAQVNL 873

  Fly  1054 DASRRPSLSQDPQQSQQQPPPPPPYYPTGTLDSKDIGNGNGGMELTLTALHDPDEQLNMQQQQHH 1118
            ....:|  ||:|.|.|...|.|.|                 .::....|:..|        |:..
Zfish   874 SYPIQP--SQNPTQGQDLNPRPKP-----------------NIQTVYAAIKLP--------QKKQ 911

  Fly  1119 SNHGQYQQPKAILGIYGGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDS--YQVLPSVANSAA 1181
            ..|...||.|.            ||                     :|:.|  |..|..
Zfish   912 KRHSPKQQQKT------------GN---------------------MDNTSMNYVTLDF------ 937

  Fly  1182 GSHGHGSGHGHGLGAGESGPLEATPPTCNISGGSSSNSGINPMQQQHSARANLTNQPTIATASST 1246
                          .|::.|.:..|.|..:....|.|      :|..|::|..::...:::|.:.
Zfish   938 --------------KGQNEPRKIMPETSAVYAMVSRN------KQAKSSQAENSDYENVSSACAP 982

  Fly  1247 NNYNNHLNNTNIAHTTNNTNNCTTLKRGHLGNRERERERCQVTAATAATTTALATTITTTSRNAK 1311
            .     |..||:...::.:                |.|....:..:.:|..|:........|:.
Zfish   983 K-----LPLTNMEWESDTS----------------EEEEVNYSTVSCSTKPAVKEVKPNQKRHF- 1025

  Fly  1312 AATTTTTLAITGSSSNSNENNYSNARDL 1339
                        |||:|:|::.:...|:
Zfish  1026 ------------SSSSSDEDDRTEYSDI 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	16/57 (28%)
		IG_like	141..228	CDD:214653	12/94 (13%)
		Ig	147..228	CDD:299845	12/88 (14%)
		I-set	232..313	CDD:254352	14/80 (18%)
		IGc2	250..302	CDD:197706	8/51 (16%)
		IG_like	323..385	CDD:214653	14/67 (21%)
		IGc2	330..385	CDD:197706	12/54 (22%)
		Ig_2	416..501	CDD:290606	19/86 (22%)
		IG_like	418..501	CDD:214653	18/84 (21%)
		I-set	505..612	CDD:254352	23/107 (21%)
		Ig	526..611	CDD:143165	19/85 (22%)
		IG_like	633..715	CDD:214653	19/82 (23%)
		Ig	635..713	CDD:143165	18/78 (23%)
		FN3	720..838	CDD:238020	28/120 (23%)
si:dkey-24p1.1	NP_001091715.1	Ig	37..153	CDD:299845	16/57 (28%)
		IG_like	276..345	CDD:214653	16/79 (20%)
		IGc2	280..334	CDD:197706	12/64 (19%)
		IG_like	364..431	CDD:214653	16/74 (22%)
		Ig_2	365..433	CDD:290606	16/75 (21%)
		IG_like	443..518	CDD:214653	22/102 (22%)
		IGc2	451..508	CDD:197706	19/84 (23%)
		IG_like	532..612	CDD:214653	22/100 (22%)
		Ig	<570..602	CDD:299845	9/43 (21%)
		IG_like	616..694	CDD:214653	24/108 (22%)
		Ig_2	631..700	CDD:290606	20/99 (20%)
		IG_like	721..791	CDD:214653	15/113 (13%)
		Ig_2	721..785	CDD:290606	14/107 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.110