DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fred and CG45263

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:NP_731246.2 Gene:CG45263 / 50003 FlyBaseID:FBgn0266801 Length:1876 Species:Drosophila melanogaster


Alignment Length:1885 Identity:357/1885 - (18%)
Similarity:606/1885 - (32%) Gaps:580/1885 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 IGQLWLSIGL-----ISGDDSL----------DTREGVDLVLKCR-------------------F 39
            |.||.|.||:     :.|.:..          :.....|.:|.|:                   :
  Fly    30 IAQLLLLIGIAVASCLPGSEGFQRFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGIY 94

  Fly    40 TEHYDSTDFTFYWARWTCCPTLFENVAIGDVQLNSNYRLDFRPS----RGIYDLQIKNTSYNRDN 100
            |:.|:       ||  :..|| .:|   |:|     ..||..|.    .|...|.|::.:.:.|:
  Fly    95 TKKYE-------WA--SRMPT-SDN---GNV-----LHLDLHPPPVQLGGDCSLWIRSATLDFDD 141

  Fly   101 GRFECRIKAKG--TGADVHQEFYNLTVLTAPHPPM-------VTPGNLAVATEEKPLELTCSSIG 156
            |.:||::.|..  |...:..:...|.|..||..|.       |.||:...|.......:.|.|..
  Fly   142 GLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCISHY 206

  Fly   157 GSPDPMITWY---REGSTVPLQSYALKGGSKNHYT-NATLQIVPRRADDGAKYKCVVWNRAMPEG 217
            |:|...:.|:   :|.|.:..|..|.:..:...:: .:.:|:...|...|...:|..::    |.
  Fly   207 GNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHGDILRCAAYH----ES 267

  Fly   218 HMLETSVT---LNVNYYPRVEV--GPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNG--QYVS 275
            :..::.|.   |:|.|.|.:.:  .|:..|:.::|.:. |.|..||.|..|.| |.|.|  :..|
  Fly   268 YTAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDKDALV-LRCVADANPPASIV-WRRAGRSEIAS 330

  Fly   276 ATPTHTIYRVNRHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFI--ESKTHEAEEGETVLIRC 338
            ...|..:..|.|..||.|||.|.|.:|.:.:..:.|||.|||.:..  ..:...|.........|
  Fly   331 LQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFEC 395

  Fly   339 NVTANPSPINVEWLKEGAPDFRY----TGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVG 399
            ....||.| :.:|::..|...:|    :...|.:.:|..|:.|.|.||:.:.:.  ..:||  ..
  Fly   396 LADGNPLP-SFKWVQRMAHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYIN--GQERV--AI 455

  Fly   400 NSTVALLVRHRPGQAYITPNKPVVHVGNG----VTLTCSANPPGWPVPQ---YRW---------- 447
            :..|:|.|...|....:.|:...|.|..|    :|:...|:|.    ||   :.|          
  Fly   456 SDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPR----PQRVAWEWGSLRLEAGSG 516

  Fly   448 ---FR--DMDGDIG-----NTQKIL-----AQGPQYSIPKAHLGSEGKYHCHAVNE--------- 488
               ||  ||..|..     :|..||     ...|.|.:.:...|:: ::..|.:.|         
  Fly   517 IDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYYLVVENERGTD-RHAIHLIVEGTFAEPYEM 580

  Fly   489 ---LGI--GKIATIILEV----------------------------------------------- 501
               :|:  |.:|.|:|.|                                               
  Fly   581 SYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKGSTGYKSSDKDSEKADLKSRSDSTSGPQGDSI 645

  Fly   502 ---------HQPPQFLAKLQQHMTRRVGDVDYAVTCSAK----GKPTPQIRWIKDGTEIL--PTR 551
                     ||..|...:.|||.........:|.:...:    |..:|:...::....||  |||
  Fly   646 YTTPAGFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTR 710

  Fly   552 KMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEH 616
            . ..|.|| :::...:...|.....:.|.: |.|:            ::|::...:::.:.:...
  Fly   711 VXQAIDTT-SESNEQLTQQQQQDDNKNKNK-NENE------------HQNELTDQHTTSNEQRLD 761

  Fly   617 EPIVIHQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSD------GHYEISTR-- 673
            :..|.|..|........|..|:....           .||.|.:..:||      |....|::  
  Fly   762 DSSVSHNNNNNHKISSTSTTVLTNSD-----------NNNTSEVAKASDSSNSEGGSSLTSSKTS 815

  Fly   674 -----MENN---DVYTSIL-RIAHL--------QHSDYGEYICRAVNPLDSIRAPIRLQPKGSPE 721
                 :|||   |:..:.. ::.||        :|...|......|.||......:.|| |.|..
  Fly   816 SSKRDLENNMNRDIKPATAPKLLHLNVTSGEQQEHQQPGPVDPLPVGPLTPEETQVLLQ-KLSIN 879

  Fly   722 KP--------TNLKIL--EVGHNYAVLNWTPGFNGGFMSTKYLVSYRR----------------- 759
            .|        .:||.|  :.|.:...:......:.|.:..:.|:.:::                 
  Fly   880 NPFYRFRKQSNSLKELRRKTGSDAPSVRSRSETDLGQVRGQQLMPHQQHSEAKVVVVLDSKQKEV 944

  Fly   760 -VATPREQ-TLSDCSGNGYIPS-YQISSSSSNSNHEWIEFN------------------------ 797
             ::.||.. :|...|.:...|| .|:..||:...:.:..|:                        
  Fly   945 AISRPRSSVSLKTRSVSSLSPSTNQMGDSSTVITNPFSIFHDDEILTLSVNTRLRSAANARSSRP 1009

  Fly   798 ---------CFKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILA--TTKVSKIP------- 844
                     .|:.|..:..|.:.|..:...|.....:.....|.::|.  |...|..|       
  Fly  1010 QRQGRGLRRLFESNRSQNPPSEHHYLHGVPVRRFERQDFDNDSGDLLGRRTNTSSGKPKRSRAIF 1074

  Fly   845 --------------------PPLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATVPMWEIV 889
                                |.|.:||...:|               .::|:  |.:....::|.
  Fly  1075 KQLSLRKLHNRAAAEEPPSLPKLKLSYPNRTH---------------SIQSM--RASGGGGYDIQ 1122

  Fly   890 ETLTLLPSGSETTFKEAIINHVSR---------------PAHYTTATTSGRSLGVGGGSHLGEDR 939
            .|....|..:.:|......|:..|               ..::.|.|..|.||   |||......
  Fly  1123 HTTAYHPRLNHSTSPVTKANYFERLQAKTRQGIQKIRDKCRNFKTTTGEGGSL---GGSEFSGFH 1184

  Fly   940 TMALAETAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASL--SFVV 1002
            |:|..|:.   ..:..:..:.|....|   ..|.|.|||   ||.:..|..:..:.|.|  :|..
  Fly  1185 TLAKDESF---RFISDRANISSYESRC---KQATIYKSY---KSEIDLSKNLHYLDAYLEQNFDH 1240

  Fly  1003 FLGLLYAFCH-------CRRKHAAK--------------KESSSVGGGVGGGNANATANPGSTGA 1046
            .|.......|       .:||..||              |.|.|.....|....|....|.::.:
  Fly  1241 QLSTTKQSAHSVGRVSGAQRKALAKQHDPTPETPRPPRHKRSQSQAANYGANYENLGTLPIASKS 1305

  Fly  1047 KEYDLDLD-----ASRRPSLSQDPQQSQQQPPPPPP---------------YYPTGTL------- 1084
            |..:..|:     :|...|:...|..::|:|...|.               |:...|.       
  Fly  1306 KVRNTALNSDSMSSSDYASVFSGPTTNRQEPEEDPKDFKLRYEHPDKMCEYYFDNLTSYALALEE 1370

  Fly  1085 -------------------DSKDIGNGNGGMELTLTALHD------PD---EQLNMQQQQHHSNH 1121
                               |.:|......|:.:...:..|      ||   ..:.::.:.:....
  Fly  1371 SEDLLLAESAKSARFFYDDDEEDDDGDEAGLAVDGLSAEDEAAGGRPDYMARDIRIRVKVNECED 1435

  Fly  1122 GQYQQPKAILGIYGGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDSYQVLPSVANSAAGSHGH 1186
            ..:.||.:.......:|.|....|..||......|    ..:|::..         |...|..|.
  Fly  1436 ADWHQPASATSYNENLAESTFYQSLNQHLQRQEVG----DEVGLEDQ---------NLLVGERGV 1487

  Fly  1187 G--------------------SGH-------GHGLGAGESGP------------LEATPPTCNIS 1212
            |                    |.|       |.|..|||.|.            :||.......|
  Fly  1488 GENYLEHFQRHRGRNYDRTTNSAHYRRAEFYGFGRSAGEGGEQPDVDRQRRADLMEAHYARSYQS 1552

  Fly  1213 GGSS---SNSGINPMQQQHSA--RANLTNQPTIATASSTNNYNNHLNNTNIAHTTNNTNNCTTLK 1272
            |..:   :.:....|::||:|  .|..|..|  |...|..|......::::.:.|::... .|:.
  Fly  1553 GSRAKGRTRAHALEMERQHAAIPTAAATAMP--AATGSVINLALPGQSSDVLYATSSKQQ-ITMP 1614

  Fly  1273 RGHLGNR--ERERERCQVTAATAATTTALATTITTTSRNAKAATTTTTLAITGSSSN-------- 1327
            ....|.:  :.:.|...:.|..|...||:|....|....|..|||...::..|:::|        
  Fly  1615 MPTAGPQFHQPKPEPAALAAVGAVAATAMAAGTATAVTPAGGATTLVAVSSAGNANNRYMLENLR 1679

  Fly  1328 ---SNENNYS-----NARDLSQEALWRLQMATAQSQQ---IYVERPPSAFSGLVDYSGYSPHIPT 1381
               :|::.:.     |:..||..:.....|:..|.||   :.:...|:|......:.|...:..|
  Fly  1680 KYYANQHQHPPAHSVNSSSLSNSSSSNSSMSQQQQQQHLKLNLNLQPTAPKVQQQHLGNRRNSST 1744

  Fly  1382 VTSSLSQQSF------------SPTQQLAPHEMLQAAQRYGTLRKSGKQPPLPPQRKDMQQQAKP 1434
            ..:|.:..:|            :.|..:|.    |...|.||            |::..|||:.|
  Fly  1745 SNASSTADNFDTFIALRNATANTSTDYMAK----QQQHRRGT------------QQQQQQQQSVP 1793

  Fly  1435  1434
              Fly  1794  1793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 25/121 (21%)
IG_like 141..228 CDD:214653 17/93 (18%)
Ig 147..228 CDD:299845 16/87 (18%)
I-set 232..313 CDD:254352 27/84 (32%)
IGc2 250..302 CDD:197706 21/53 (40%)
IG_like 323..385 CDD:214653 15/65 (23%)
IGc2 330..385 CDD:197706 14/58 (24%)
Ig_2 416..501 CDD:290606 28/130 (22%)
IG_like 418..501 CDD:214653 28/128 (22%)
I-set 505..612 CDD:254352 20/112 (18%)
Ig 526..611 CDD:143165 15/90 (17%)
IG_like 633..715 CDD:214653 20/106 (19%)
Ig 635..713 CDD:143165 19/102 (19%)
FN3 720..838 CDD:238020 24/182 (13%)
CG45263NP_731246.2 I-set 53..149 CDD:254352 22/113 (19%)
Ig 198..281 CDD:299845 16/86 (19%)
IG_like 302..368 CDD:214653 24/67 (36%)
IGc2 302..357 CDD:197706 22/56 (39%)
Ig 372..446 CDD:299845 16/74 (22%)
Ig 475..568 CDD:299845 20/97 (21%)
IG_like 478..570 CDD:214653 21/96 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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