DRSC/TRiP Functional Genomics Resources

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Protein Alignment fred and NPHS1

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:1106 Identity:219/1106 - (19%)
Similarity:371/1106 - (33%) Gaps:340/1106 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LLIIGQL-----WLSI------GLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCP 59
            ||::|.|     .|:|      |..:..::|...||..:.|:|..:    :......||:     
Human    11 LLLLGLLTEGLAQLAIPASVPRGFWALPENLTVVEGASVELRCGVS----TPGSAVQWAK----- 66

  Fly    60 TLFENVAIG-DVQLNS--NYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFY 121
               :.:.:| |.::..  .|||:..|:||.:.|.|:....: |:..:||::.....|.::.....
Human    67 ---DGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLS-DDAEYECQVGRSEMGPELVSPRV 127

  Fly   122 NLTVLTAPHPPMVTP--GNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTV-PLQSYALKGGS 183
            .|::|..|...::||  |.:......:...:.|.|....|.|.||....|.|: .:.:...:|..
Human   128 ILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTISDISANVNEGSQ 192

  Fly   184 KNHYT-NATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPL----K 243
            :..:| .||.::.||.:|:.....|...:.|:..  .::.|.|:||.:.|    ||  |:    .
Human   193 QKLFTVEATARVTPRSSDNRQLLVCEASSPALEA--PIKASFTVNVLFPP----GP--PVIEWPG 249

  Fly   244 VERDHV-----AKLDCRVDAKPMVSNVRWSRNGQYVS-ATPTHTIYRVNR----------HHAGK 292
            ::..||     .:|.|.......::.::|.:|||.|| |..|.....|.|          .|..:
Human   250 LDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQ 314

  Fly   293 YTCSADNGLGK-TGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEW----- 351
            .:|.|.|.:.. |.|..|.|.|.:||...|...:....|.:.|.:.|...::...:.:.|     
Human   315 LSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWLGWR 379

  Fly   352 ----LKEGAPDFRYTGEL----LTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVR 408
                ::|...|..:.|.:    ||..:.|.::.....|      :.||....:.....::.|.|:
Human   380 QLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTC------EAFSEAFTKETFKKSLILNVK 438

  Fly   409 HRPGQAYI--TPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRD--------------------- 450
            :...:.:|  .|....:..|..|.|.|.| ..|.|.|...|::|                     
Human   439 YPAQKLWIEGPPEGQKLRAGTRVRLVCLA-IGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSV 502

  Fly   451 -MDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKI-ATIILEVHQPPQFLAKLQQ 513
             ..|...:.:.:|..||.        .::.|:.|.|      |:: |:..|.|..||..:..|..
Human   503 EKSGSTFSRELVLVTGPS--------DNQAKFTCKA------GQLSASTQLAVQFPPTNVTILAN 553

  Fly   514 HMTRRVGDVDYAVTC-SAKGKPTPQIRWIKDGTEI-----LPTRKMFD---------IRTTPTDA 563
            ....|.||. ..:|| |....|...:.|.|:|..:     .|.|..|.         ::.:..|.
Human   554 ASALRPGDA-LNLTCVSVSSNPPVNLSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDH 617

  Fly   564 GGGVV----------AVQSILRFRGKARP--------------NGNQLLP--------------- 589
            |..|.          .|.|..|.....||              .|..|||               
Human   618 GQRVTCRAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWT 682

  Fly   590 -----------------------------NDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYN 625
                                         .|.|||....:|...:|.:.:.|.:.:.|.:....:
Human   683 FRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQD 747

  Fly   626 KVAYDLRESAEVVCRVQAYP--KPEFQW----------------------------------QYG 654
            ....::..|.::||.|.|.|  ...|.|                                  |.|
Human   748 PTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG 812

  Fly   655 ----------------------------NNPSPLTMSS--------------------------- 664
                                        .:|:|||..:                           
Human   813 AYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTK 877

  Fly   665 --------DGHYEISTRMENNDVYTSILRIAHLQHS-DYGEYICRAVNPLDSIRAPIRLQPKGSP 720
                    |..|...| .....|::|:|.||::..: ||..:.|.|.|.|.|.:..|:|.....|
Human   878 NGVPLDLQDPRYTEHT-YHQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRP 941

  Fly   721 EKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSS 785
            :.|:.||::.:..:...|.|.|||:|| :..::.:.|..:.||         |..|:......::
Human   942 DPPSGLKVVSLTPHSVGLEWKPGFDGG-LPQRFCIRYEALGTP---------GFHYVDVVPPQAT 996

  Fly   786 SSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILATTKVSKIP---PPL 847
            :..                 |..|.....|...:.|.|:.|.||.::      |.:::|   |.|
Human   997 TFT-----------------LTGLQPSTRYRVWLLASNALGDSGLAD------KGTQLPITTPGL 1038

  Fly   848 H 848
            |
Human  1039 H 1039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 21/99 (21%)
IG_like 141..228 CDD:214653 19/88 (22%)
Ig 147..228 CDD:299845 19/82 (23%)
I-set 232..313 CDD:254352 26/101 (26%)
IGc2 250..302 CDD:197706 16/62 (26%)
IG_like 323..385 CDD:214653 11/74 (15%)
IGc2 330..385 CDD:197706 11/67 (16%)
Ig_2 416..501 CDD:290606 22/109 (20%)
IG_like 418..501 CDD:214653 21/105 (20%)
I-set 505..612 CDD:254352 33/189 (17%)
Ig 526..611 CDD:143165 28/167 (17%)
IG_like 633..715 CDD:214653 30/181 (17%)
Ig 635..713 CDD:143165 28/177 (16%)
FN3 720..838 CDD:238020 24/117 (21%)
NPHS1NP_004637.1 V-set 38..119 CDD:284989 20/93 (22%)
IG_like 38..113 CDD:214653 20/87 (23%)
C2-set_2 141..228 CDD:285423 20/88 (23%)
Ig 240..321 CDD:299845 21/86 (24%)
IG_like 254..336 CDD:214653 22/81 (27%)
Ig 345..424 CDD:299845 13/84 (15%)
Ig 445..530 CDD:299845 18/93 (19%)
I-set 446..541 CDD:254352 22/109 (20%)
Ig 549..632 CDD:299845 17/83 (20%)
IG_like 558..642 CDD:214653 19/84 (23%)
I-set 646..736 CDD:254352 12/89 (13%)
Ig 662..736 CDD:299845 11/73 (15%)
Ig_3 739..820 CDD:290638 11/80 (14%)
IG_like 748..821 CDD:214653 10/72 (14%)
Ig8_hNephrin_like 834..942 CDD:143250 21/108 (19%)
IG_like 845..935 CDD:214653 19/90 (21%)
fn3 942..1023 CDD:278470 21/107 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137
Binds to NPHS2 1160..1241
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11640
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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