DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and hbs

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1125	Identity:	230/1125 - (20%)
Similarity:	381/1125 - (33%)	Gaps:	362/1125 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LDTREGVDLVLKCRFTEHYDSTDFT---FYWARWTCCPTLFENVAIGDVQLNSNYRLDFRPSRGI 86
            |...||.|.:|:|..:.......:|   |........|.......:.|.:.|:
  Fly    48 LQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNA------------ 100

  Fly    87 YDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPG---NLAVATEEKP- 147
            |:|||||.:. .|:..::|:: ....|....:....|:::.|| ..:|..|   |..|..||:.
  Fly   101 YNLQIKNATL-EDDAEYQCQV-GPAAGNPAIRANAKLSIVAAP-SSIVIEGYARNARVEVEERQN 162

  Fly   148 LELTCSSIGGSPDPMITWYREG----STVPLQSYALKGGSKNHYTNATLQIVPRRADDGAKYKCV 208
            |.|.|.:...:|...|.|: :|    ||.|:.: ..:...|...|::||.:.||..||..::.|.
  Fly   163 LTLHCIAENANPAAEIVWF-QGEVPVSTAPIVT-VNQTAPKRFTTSSTLHLQPRAEDDYKEFSCE 225

  Fly   209 VWNRAMPEGHMLETSVTLNVNYYPRVEV--GPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNG 271
            ..::|:|....:...|.|:|.|.|....  |......:.|....::.||.......:.:.|.|||
  Fly   226 ARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNG 290

  Fly   272 QYVSATPTHTIYRVNRHHAGKYTCSA-DNGLGKTGE-----------KDIVLDVLYPPIVFIESK 324
            ..:| :|..|..|:: .:..|:|.:| |||.....|           .::.|.|||.|.....|.
  Fly   291 VAIS-SPQRTSGRLS-ENVYKFTAAAEDNGANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSG 353

  Fly   325 THEAEEGETVLIRCNVTANPSP-INVEWLKEGAP----DFRYTGE-----------LLTLGS--- 370
            .::|:.|::|.:.| |||..:| ..:.|...|.|    .::.|..           .||:.|
  Fly   354 ANQAKVGDSVQLSC-VTAPSNPQARISWSINGRPLDNSTYKTTSSSDGGWVSSSNISLTIDSQSR 417

  Fly   371 --------VRAEHAGNYI-CRSVNIMQPFS----------------------------------- 391
                    :..|...|.: ..:||::.|.|
  Fly   418 TFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQ 482

  Fly   392 -----------SKRVEGVGNSTVALLVR-----------------------------HRPGQAY- 415
                       ||.|:....|.::|||.                             |.|.:..
  Fly   483 WYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVK 547

  Fly   416 --ITP---------------------------------------NKPVVHVG------------- 426
              :.|                                       |:|.:..|
  Fly   548 ISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMYVNITQ 612

  Fly   427 --NGVTLTCSAN------------------PPGWPVPQ--------------------------Y 445
              :|:..||.::                  ||.:..||                          |
  Fly   613 DLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVITY 677

  Fly   446 RWFRD---MDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKIATIILEVHQPPQF 507
            .|.:|   :..:..:.|::::.||:.:|.:......|.|.|.|:|..|     |.:||:....::
  Fly   678 TWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGVYICEALNSQG-----TALLEIQVAVEY 737

  Fly   508 LAKLQQHMTRR--VGDVDYAVTCSAKGKP--TPQIRWIKDGTEILPTRKMFDIRTTPTDAGGGVV 568
            ...:......|  |......:.|..:.:|  ...:||.:||.::
  Fly   738 APTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDGYDL--------------------- 781

  Fly   569 AVQSILRFRGKARPNGNQLLP------NDRGLYTCLYENDVNS-ANSSMHLRIEHEPIVIHQ--Y 624
            |.::|..|.     ||..||.      :|.|.:||:.:|...: |..::.|.::..|.:.|.  :
  Fly   782 ATRTISSFE-----NGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGF 841

  Fly   625 NKVAYDLRESAEVVCRVQAYPKPEFQW-QYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAH 688
            .:.|..|...|:::||..|.|:|.|.| ::|.:   |.|.....::...|..:...:.|.|.|.:
  Fly   842 TRYAARLGVRAQLICRSLASPQPSFIWRRHGKD---LKMQRRNKFKSVERQVDALNFESALLIEN 903

  Fly   689 LQHSDYGEYICRAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKY 753
            ....|||:|.|...|.|......:.......|:.|..|::..|......|||||||:|| |.|.:
  Fly   904 TSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGG-MQTYF 967

  Fly   754 LV--------SYRRV-ATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPL 809
            .:        .|:.| |.|..|.:|                                    |..|
  Fly   968 RLRLKQHGEDKYKYVDAKPGHQNIS------------------------------------LDGL 996

  Fly   810 DQHQSYMFKVYALNSKGTSGYSNEILATTKVSKIPPPLHVSYD-----PNSHVLGINVAATCLSL 869
            ....:|.|.|.|.|..|.|.:..:|..|  :||...|....|.     ||..::||..||..|.:
  Fly   997 KPGATYYFSVMAANEAGGSKFMPDIKLT--LSKGSQPHSAEYTEKDELPNVMIIGITSAAMVLLV 1059

  Fly   870 IAVVESLVTRDATVPMWEIV 889
            :         :|.:..|.::
  Fly  1060 L---------NAALVAWFVI 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	20/99 (20%)
		IG_like	141..228	CDD:214653	26/91 (29%)
		Ig	147..228	CDD:299845	23/85 (27%)
		I-set	232..313	CDD:254352	21/94 (22%)
		IGc2	250..302	CDD:197706	16/52 (31%)
		IG_like	323..385	CDD:214653	18/89 (20%)
		IGc2	330..385	CDD:197706	16/82 (20%)
		Ig_2	416..501	CDD:290606	26/185 (14%)
		IG_like	418..501	CDD:214653	26/183 (14%)
		I-set	505..612	CDD:254352	21/117 (18%)
		Ig	526..611	CDD:143165	19/93 (20%)
		IG_like	633..715	CDD:214653	22/82 (27%)
		Ig	635..713	CDD:143165	22/78 (28%)
		FN3	720..838	CDD:238020	31/126 (25%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845	19/87 (22%)
		IG_like	45..137	CDD:214653	21/102 (21%)
		Ig	153..231	CDD:299845	22/79 (28%)
		IG_like	258..342	CDD:214653	19/85 (22%)
		Ig	266..327	CDD:299845	17/62 (27%)
		IG_like	357..>414	CDD:214653	14/57 (25%)
		Ig	360..427	CDD:299845	14/67 (21%)
		Ig	<468..526	CDD:299845	7/57 (12%)
		I-set	547..633	CDD:254352	7/85 (8%)
		Ig	556..631	CDD:299845	6/74 (8%)
		I-set	644..735	CDD:254352	19/95 (20%)
		IGc2	668..725	CDD:197706	12/56 (21%)
		IG_like	751..829	CDD:214653	21/103 (20%)
		IGc2	753..815	CDD:197706	17/87 (20%)
		Ig	852..928	CDD:143165	22/78 (28%)
		FN3	935..1017	CDD:238020	30/118 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840