DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and sns

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	1627	Identity:	332/1627 - (20%)
Similarity:	531/1627 - (32%)	Gaps:	548/1627 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCP-----TLFENVAIGDVQLNSNYRLD 79
            |.:..::.||..||.|||.......:....:|.......|     |:.|:.|   .:..:...|.
  Fly   183 SHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTA---KRFTTTSSLK 244

  Fly    80 FRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADV-HQEFYNLTVLTAPHPPMVTPGNLAVAT 143
            .:|..            :.|...:.|:.:.|....|: .:....|:||..|.||.: .|..|..|
  Fly   245 LKPGP------------DDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYI-EGYSAGET 296

  Fly   144 --EEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYALKGG-SKNHYTNATLQIVPRRADDGAKY 205
              ..:.:||.|.|.||:|...:.||:.||.:.: :|...|. |:|.||     ......|:.|::
  Fly   297 LRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRM-AYRTSGRLSENIYT-----FTAEAGDNKARF 355

  Fly   206 KCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRN 270
            :|...|  :...:.|:..|.|:|.:.| ..|....|.:.....:..|.|........:.::|...
  Fly   356 RCEASN--VMSQNPLKAEVELSVLFAP-THVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVG 417

  Fly   271 GQYVSATPTHTIYRVNRHHAGKYTCSAD----------------NGLGKTGEKDIV----LDVLY 315
            |:.|....:.||....    |.:|.:::                :||.....:::|    ::|||
  Fly   418 GRQVRNATSKTIVSPE----GGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLY 478

  Fly   316 PP----------------------------------------------IVFIESKTHEAE----- 329
            ||                                              ::....|:..||
  Fly   479 PPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILA 543

  Fly   330 --------------------------------EGETVLIR---------------CNVTANPSPI 347
                                            ..|||.||               |:.:::..|.
  Fly   544 NVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPA 608

  Fly   348 NVEWLKEGAP---------DFRYTGELLTLG---SVRAEHAGN-YICRSVNIMQPFSSKRVEGVG 399
            .:.|.|:|.|         ...:.|.:.||.   :|..|..|. |.|:|.|       :.::...
  Fly   609 KLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN-------EALQRSA 666

  Fly   400 NSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVP-QYRWFRD-----MDGDIGNT 458
            :..|:|.|.:||  .::.|.........|.:|..|......|.| .|:|.:|     .|||
  Fly   667 HEAVSLDVLYRP--KFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGD---- 725

  Fly   459 QKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKI-ATIILEVHQPPQFLAKLQQHMTRRVGDV 522
            .:|.|.|...:..:.|....|.|.|.|.|..|...: .|:::|....   :..:.:::....|:
  Fly   726 HRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTT---IKSVSENIVVNPGE- 786

  Fly   523 DYAVTCSAKGKPTPQ--IRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGN 585
            |..::|:.:|||..:  ::|.:.|.::       .::|:.|.|.|     .|.|..:...|
  Fly   787 DAMLSCTVEGKPLTEEHVKWERVGYDM-------TVKTSTTFANG-----TSYLHIKDAKR---- 835

  Fly   586 QLLPNDRGLYTCLYENDV-NSANSSMHLRIEHEPIVIHQYN--KVAYDLRESAEVVCRVQAYPKP 647
                .|.|.:.|:.:|.| |..|..:.|.::..|.:.....  :.|....|...:.||.|..|||
  Fly   836 ----EDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKP 896

  Fly   648 EFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICRAVNPLDSIRAPI 712
            :|.|:......|:..:.  .||:..|..::..|.|.|.:..:..:|||.|.|.|.|.|......:
  Fly   897 QFIWRQDKKDLPINRTY--KYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETV 959

  Fly   713 RLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSGNGYI 777
            ||:....|:.|.:|.||.|.|:...|.|||||:|| :...|.|.||  ...|||
  Fly   960 RLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGG-LKASYRVRYR--MADREQ----------- 1010

  Fly   778 PSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILATTKVSK 842
              |:......||            :...:..|..:..|:|.|.:.|..|.|.|..: ||..:..:
  Fly  1011 --YKYIDGLPNS------------HKLTIGGLRMNTLYLFSVMSWNELGQSSYLPD-LARAETKE 1060

  Fly   843 IPPPLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATVPMWEIVETLTLLPSGSETTFKEAI 907
            .|||.|    |.|.:.|                                      |..||.:..:
  Fly  1061 APPPSH----PASSLGG--------------------------------------GPPTTSQTPL 1083

  Fly   908 INHVSRPAHYTTATTSGRSL-GVGGGSHLGEDRTMALAETAGPGPVVRVKL-------CLRSNHE 964
                        ..|||..| |||.|                   :|.|.|       ||...:|
  Fly  1084 ------------GGTSGMLLVGVGAG-------------------IVVVLLNVFVIGCCLHKRNE 1117

  Fly   965 HCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLGLL-------YAFCHCRRKHAAKKE 1022
                 ...:.|...||.:.:..:|....::|..:|...|..||       :.|.|.|||..|:..
  Fly  1118 -----KRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETT 1177

  Fly  1023 S-------------SSVGGGVGGGNANAT-------ANPGSTGAKEYDLDLDASRRPSLSQDPQQ 1067
            :             ||....|.|...::.       :|.||: ..||   :|..|:.:.|....:
  Fly  1178 NQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSS-QPEY---IDEVRKKAASTYLVE 1238

  Fly  1068 SQQQPPPP-------PPYYPTG-----TLDSKDIGNGNGGMELTLTALHDPDEQLNMQQQQHHSN 1120
            ....|||.       |..||..     ||......||:..:.:|      .|:|:.:.:
  Fly  1239 GSDMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMT------RDDQMLISK------ 1291

  Fly  1121 HGQYQQPKAILGIYGGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDSYQVLPSVANSAAGSHG 1185
                       |:|        ..|....|..:|..|:      ::||.|...|.:...||
  Fly  1292 -----------GVY--------IPSPSPAPPPDGSYYN------MNSDRYLSYPPMEYPAA---- 1327

  Fly  1186 HGSGHGHGLGAGESGPLEATPPTCNISGGSSSNSGINPMQQQHSARANLTNQPTIATASSTNNYN 1250
                            |:.|               ..||...|.       ||...|:.:||...
  Fly  1328 ----------------LDFT---------------AQPMPMAHL-------QPMTVTSLATNGGP 1354

  Fly  1251 NHLNNTNIAHTTNNTNNCTTLKRGHLGNRERERERCQVTAATAATTTALATTITTTSR------- 1308
            ..:.|.::|.....:.   ||:||.|..         |........|...:|:..:..
  Fly  1355 TLIGNGSVAAVAGGSG---TLRRGILRG---------VVGVPQPDVTHHTSTVGGSPMQMLHDLH 1407

  Fly  1309 --NAKAATTTTTLAITGSSSNSNENNYSNARDLSQEALWRLQMATAQSQQIYVERPPSAFSGLVD 1371
              |..|:|.||:..:.||
  Fly  1408 PVNLSASTLTTSTTLNGS----------------------------------------------- 1425

  Fly  1372 YSGYSPHIPTVTSSLSQQSFSPTQQLAPHEMLQAAQRYGTLRKSGKQPPLPPQRKDMQQQAKPPQ 1436
                   :||.|::|.:|         ||.:|:...|       .||.....|::..|||.:..|
  Fly  1426 -------LPTATATLPRQ---------PHGILKDPNR-------NKQQQQQQQQQQQQQQLQHQQ 1467

  Fly  1437 QM 1438
            |:
  Fly  1468 QL 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	18/102 (18%)
		IG_like	141..228	CDD:214653	25/89 (28%)
		Ig	147..228	CDD:299845	24/81 (30%)
		I-set	232..313	CDD:254352	15/100 (15%)
		IGc2	250..302	CDD:197706	10/67 (15%)
		IG_like	323..385	CDD:214653	23/126 (18%)
		IGc2	330..385	CDD:197706	20/82 (24%)
		Ig_2	416..501	CDD:290606	23/91 (25%)
		IG_like	418..501	CDD:214653	23/89 (26%)
		I-set	505..612	CDD:254352	22/109 (20%)
		Ig	526..611	CDD:143165	20/87 (23%)
		IG_like	633..715	CDD:214653	25/81 (31%)
		Ig	635..713	CDD:143165	23/77 (30%)
		FN3	720..838	CDD:238020	35/117 (30%)
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	19/107 (18%)
		Ig	197..279	CDD:299845	15/96 (16%)
		IG_like	296..376	CDD:214653	25/87 (29%)
		Ig	300..361	CDD:299845	20/66 (30%)
		Ig	380..454	CDD:299845	12/78 (15%)
		IG_like	490..573	CDD:214653	3/82 (4%)
		Ig	501..560	CDD:299845	3/58 (5%)
		Ig	584..666	CDD:299845	16/88 (18%)
		IG_like	585..666	CDD:214653	16/87 (18%)
		I-set	678..767	CDD:254352	24/94 (26%)
		IGc2	692..757	CDD:197706	20/68 (29%)
		Ig	788..849	CDD:143165	17/80 (21%)
		Ig	885..960	CDD:143165	23/76 (30%)
		FN3	967..1051	CDD:238020	33/111 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840