DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and side-VI

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster

Alignment Length:	1349	Identity:	271/1349 - (20%)
Similarity:	439/1349 - (32%)	Gaps:	453/1349 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 CRIKAKGTGADVHQEFYNLTVLTAPHPPMVTP-GNLAVATEEKPLELTCSSIGGSPDP----MIT 164
            |.|....|.|:.|:           |.....| |.:.........::.| .:|.|...    ::.
  Fly    10 CLIMGAITHANSHE-----------HADGFKPDGEILRVLVNSSAQIKC-DVGSSQADDKVLLVV 62

  Fly   165 WYREGSTVPLQSYALKG---GSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTL 226
            ||:  :.:|:.||..:|   |:.:|:.:..                |:.:||:...|.....:.:
  Fly    63 WYK--NNLPIYSYDTRGAHAGTPSHWRDEE----------------VLEDRAVFRTHKEPAELII 109

  Fly   227 NVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAG 291
                         ||:| |:|                                          ||
  Fly   110 -------------NPVK-EKD------------------------------------------AG 118

  Fly   292 KYTCSADNGLGKTGEKDIVLDVLYP---PIVF------IESKTHEAEEGETVLIRCNVTANPSPI 347
            .:.|..|..|.:|...::.|:|:.|   ||:|      |:|:....|||.::.:.|.|.....|.
  Fly   119 NFRCRVDFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPYEEGGSLEVTCVVYGGSPPP 183

  Fly   348 NVEWLKEG-----APDFRYTG----ELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTV 403
            .|.||..|     ..|:.|.|    :|:.....|......|.|::.|    |..|.|  ..|.|:
  Fly   184 TVIWLMNGQLQNSVVDYTYDGAINSKLVVRNLSRIHQHAVYTCQASN----FHKKYV--ATNITI 242

  Fly   404 ALLVRHRPGQAYITPNKPVVHVGNGVTLTCSA---NPPG---WPVPQYRWFRDMDGDIGNTQKIL 462
            .|.:  ||....|:.|...:.......:.|.|   .||.   |      |..:::.. |::||:.
  Fly   243 DLYL--RPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITW------WMGNLELH-GHSQKVS 298

  Fly   463 AQGPQYSIPKAHLG------SEGK-YHCHAVNEL---GIGKIATIILEVHQPPQFLAKLQQHMTR 517
            ..|   ::..:.|.      ..|| ..|.|.|||   ||.:.| :.|.|.    |:..||..:..
  Fly   299 EDG---NVSTSVLSITPTREDHGKALSCRATNELVRNGIRETA-MKLNVF----FIPTLQLDLGS 355

  Fly   518 RV-------GDVDYAVTCSAKGKPTP-QIRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSIL 574
            .:       || |....|.....|.. ::.| |...:|:...:.           .||:.....|
  Fly   356 NLNPEDIEEGD-DVYFECKVHANPAAYKVVW-KHNHQIIQHNQR-----------AGVIVSSGDL 407

  Fly   575 RFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSS-MHLRIEHEPIVIHQYNKVAYDL--RESAE 636
            ..:|..|        :..|.|||...|.....:|: :.|::.::||......|: |.:  .|:||
  Fly   408 ALQGVTR--------HQAGNYTCTASNVEGDGDSNVVELKVMYKPICRPDQKKI-YGVARNEAAE 463

  Fly   637 VVCRVQAYPKPE-FQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICR 700
            :||.|.|:|.|| |:|.:.|......|...|       ...:....|.|....::..|:|..:|.
  Fly   464 IVCEVDAFPPPENFKWSFNNTAETFDMPQSG-------FRPHSAQGSTLTYTPVKEMDFGTIMCW 521

  Fly   701 AVNPLDSIRAP--IRLQPKGSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYLVSYRRVATP 763
            |.|.:...:.|  ..|...|.||.|||..::....:...:....||:|| |...:|:
  Fly   522 ADNNVGQQKEPCVFHLIAAGKPEAPTNCTVVNQTSDSLEVYCIEGFDGG-MRQWFLM-------- 577

  Fly   764 REQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKVYALNSKGTS 828
              :.....||       |:.::.|           .|.....:..||..:.:...|||:|.:|.|
  Fly   578 --EIFDQHSG-------QLQANIS-----------AKFAALSVTGLDAGRLFRIYVYAVNGRGRS 622

  Fly   829 ------GYS-----NEILATTKVS---------KIPPPLHVSYDPNSHVLGINVAATCLSLIAVV 873
                  ||:     .:.:|.|...         ::.|.|.:..     .:||.||..|:. |..:
  Fly   623 DAIALDGYTLKAAEKQTVALTSYKGSAQSPDNFELTPILSIGI-----FVGILVAIVCIG-IGTI 681

  Fly   874 ESLVTRD----------------ATVPMWEIVETLTLLPSGSETTFKEA---IINHVSRPAHY-- 917
            .:|..|.                :.....:|.:.::|..|.||..:.|.   ::.:......|
  Fly   682 AALKLRSHKHQQQQKFVHPNAKFSRPGNLQIKDKISLPLSHSEEMYDEKNPDVVPYNEVDGEYKQ 746

  Fly   918 --TTATTSGRSLGVGGGSHLGEDRTMALA----ETAGPGPVVRVKLCLRSNHEHCGAYAN----- 971
              .|.|.||         ||.....:.::    .|:|.|.|       ::|....|.|.:
  Fly   747 KSATQTPSG---------HLSTTSEVEISCKPGSTSGTGIV-------QANSADSGTYQSSKDDE 795

  Fly   972 ---AEIGKSYMPHKSSMTTSALVAIIIASLSFVVFLGLLYAFCHCRRKHAAKKESSSVGGGVGGG 1033
               ||:..:.||..||                                 .|.|:...:||
  Fly   796 LHYAELSLTNMPSGSS---------------------------------GASKKGQPMGG----- 822

  Fly  1034 NANATANPGSTGAKEYDLDLDASRRPSLSQDPQQSQQQPPPPPPYYPTGTLDSKDIGNGNGGMEL 1098
                      .|..::           :.|..||.||.....|.....|||.     :|:...:|
  Fly   823 ----------VGVVQH-----------VVQQQQQQQQGQVQHPHQLLGGTLP-----HGSSMRKL 861

  Fly  1099 TLTALHDPDEQLNMQQQQHHSNHGQYQQPKAILGIYGGVAGSGGNNSGGQHPHSNG------YGY 1157
            .      |........|:|..|.|                       |.||||.:.      |.|
  Fly   862 L------PTIPATATLQRHKPNAG-----------------------GMQHPHQHAPPPTYDYDY 897

  Fly  1158 HVTSAIGVDSDSYQVLPSVANSAAGSHGHGSGHG-HGLGAGESGP-LEATPPTCN---------- 1210
            .....|....|:|:.:...........|.|:|.| :|.||..|.| ...||.|.:
  Fly   898 FEEPTIYAQIDAYKTMQVDTGVVVAGVGAGAGSGVNGAGASISSPGSHGTPSTVSPGTVQMYTLP 962

  Fly  1211 ------------------ISGG-SSSNSGINPMQQQHSARANLTNQPTIATASSTNNYNNHLNNT 1256
                              ::|| .:|.|.:..||||...:..:.:.|......|...:.......
  Fly   963 QHPGGYHTLPHNHHAQQQMAGGPQNSASMMQMMQQQQQQQQQMHHHPASNMPPSYQQHQQQQQQQ 1027

  Fly  1257 NIAH-----TTNNTNNCTTLKRGHLGNRERERERCQVTAATAATTTALA 1300
            .:||     ::|::...:|                  |||.|:.:::|:
  Fly  1028 QMAHGQMLVSSNSSGLAST------------------TAAVASPSSSLS 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	5/20 (25%)
		IG_like	141..228	CDD:214653	15/93 (16%)
		Ig	147..228	CDD:299845	15/87 (17%)
		I-set	232..313	CDD:254352	12/80 (15%)
		IGc2	250..302	CDD:197706	4/51 (8%)
		IG_like	323..385	CDD:214653	18/70 (26%)
		IGc2	330..385	CDD:197706	16/63 (25%)
		Ig_2	416..501	CDD:290606	24/100 (24%)
		IG_like	418..501	CDD:214653	23/98 (23%)
		I-set	505..612	CDD:254352	22/115 (19%)
		Ig	526..611	CDD:143165	16/86 (19%)
		IG_like	633..715	CDD:214653	23/84 (27%)
		Ig	635..713	CDD:143165	22/80 (28%)
		FN3	720..838	CDD:238020	27/128 (21%)
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	27/179 (15%)
		Ig_3	157..230	CDD:290638	19/72 (26%)
		IG_like	165..242	CDD:214653	22/82 (27%)
		Ig	265..343	CDD:299845	22/88 (25%)
		IG_like	267..343	CDD:214653	22/86 (26%)
		IG_like	363..440	CDD:214653	20/97 (21%)
		IGc2	364..429	CDD:197706	18/85 (21%)
		IG_like	456..532	CDD:214653	22/82 (27%)
		Ig_3	456..524	CDD:290638	21/74 (28%)
		fn3	545..622	CDD:278470	21/105 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810