Protein Alignment fred and BCAM

DIOPT Version :10

• Sequence 1: NP_608812.3
• Gene: fred / 33613
• FlyBaseID: FBgn0051774
• Length: 1447
• Species: Drosophila melanogaster
• Sequence 2: NP_005572.2
• Gene: BCAM / 4059
• HGNCID: 6722
• Length: 628
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 131/524 - (25%)
• Similarity: 191/524 - (36%)
• Gaps: 132/524 - (25%)

  Fly    25 LDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCC------PTLFE--------NVAIGDVQLNS- 74
            ::...|..::|.|..|..:|     .|...|...      |.|..        .|.:.|.:..|
Human    41 VEVMRGKSVILDCTPTGTHD-----HYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSP 100

  Fly    75 NYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTP--G 137
            .|:||   |:|...|........||   :.|.::|...|  ..:....|.|...|....|:|  |
Human   101 PYQLD---SQGRLVLAEAQVGDERD---YVCVVRAGAAG--TAEATARLNVFAKPEATEVSPNKG 157

  Fly   138 NLAVATEEKPLELTCSSIGGSPDPMITWYREGS--TVPLQ--------SYALKGGSKNHYTNATL 192
            .|:|..:......||:|..|:|.|.|||||.|.  .||::        |..::..|......:||
Human   158 TLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTL 222

  Fly   193 QIVPRRADDGAKYKCVVWNRAMPEG-HMLETSVTLNVN-YYPRVEV-----GPQNPLK-VERDHV 249
            .:..|:.|..|.:.|.. :.::||| |....|.|.::. :||...|     .|..|.. |.....
Human   223 YLRLRKDDRDASFHCAA-HYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDT 286

  Fly   250 AKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYR---------------------VNRHHAGKY 293
            .:|.||.|..|                :|.:|::|                     |.|..:|.|
Human   287 VQLLCRGDGSP----------------SPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTY 335

  Fly   294 TC------SADN-GLGKTGEKDIVLDVLY-PPIVFIESKTHEAEEGETVLIRCNVTANPSPINVE 350
            .|      :||: .|.||.|    |.|.| .|:...|.|........:.::.|:|...|:|. :.
Human   336 GCRVEDYDAADDVQLSKTLE----LRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPA-LR 395

  Fly   351 WLKEGAP--DFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRP-- 411
            |.|:..|  |    |.:|:|.|:..:..|.|:|.:.....|..|:      .....|||:..|
Human   396 WTKDSTPLGD----GPMLSLSSITFDSNGTYVCEASLPTVPVLSR------TQNFTLLVQGSPEL 450

  Fly   412 GQAYITPNKP-VVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHL 475
            ..|.|.|... ....|:.|||.|||.  |.|.|:..|.:            |...|...||
Human   451 KTAEIEPKADGSWREGDEVTLICSAR--GHPDPKLSWSQ------------LGGSPAEPIP---- 497

  Fly   476 GSEG 479
            |.:|
Human   498 GRQG 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	132..228	CDD:472250	33/108 (31%)
		Ig strand B	148..152	CDD:409353	0/3 (0%)
		Ig strand C	162..166	CDD:409353	2/3 (67%)
		Ig strand E	190..194	CDD:409353	2/3 (67%)
		Ig strand F	204..209	CDD:409353	1/4 (25%)
		Ig strand G	221..224	CDD:409353	0/2 (0%)
		Ig	238..313	CDD:472250	23/103 (22%)
		Ig strand B	250..254	CDD:409353	1/3 (33%)
		Ig strand C	264..268	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	1/3 (33%)
		Ig strand F	292..297	CDD:409353	2/10 (20%)
		Ig strand G	306..309	CDD:409353	1/2 (50%)
		Ig_3	316..385	CDD:464046	18/70 (26%)
		Ig_2	416..501	CDD:464026	19/65 (29%)
		Ig	523..614	CDD:472250
		Ig strand B	524..528	CDD:409568
		Ig strand C	537..541	CDD:409568
		Ig strand E	566..570	CDD:409568
		Ig strand F	594..599	CDD:409568
		Ig strand G	607..610	CDD:409568
		Ig_3	618..703	CDD:464046
		FN3	720..838	CDD:238020
BCAM	NP_005572.2	V-set	37..143	CDD:462230	24/114 (21%)
		C2-set_2	151..248	CDD:400489	30/97 (31%)
		Ig strand C	182..186	CDD:409416	2/3 (67%)
		IG_like	280..358	CDD:214653	21/97 (22%)
		Ig strand B	287..291	CDD:409353	1/3 (33%)
		Ig strand C	300..304	CDD:409353	1/3 (33%)
		Interaction with laminin alpha5	309..312		0/2 (0%)
		Ig strand E	320..324	CDD:409353	0/3 (0%)
		Ig strand F	334..339	CDD:409353	2/4 (50%)
		Ig_2	363..437	CDD:464026	20/84 (24%)
		Ig_3	464..526	CDD:464046	17/56 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..628