DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and kirrel1a

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001349348.1	Gene:	kirrel1a / 405804	ZFINID:	ZDB-GENE-040426-2126	Length:	819	Species:	Danio rerio

Alignment Length:	849	Identity:	180/849 - (21%)
Similarity:	287/849 - (33%)	Gaps:	259/849 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQI 91
            |..:||.| ...:|...      .:||     .:.:|:|   |::....||:......|.|:|:|
Zfish    34 GQRVVLSC-VVFNYSGI------VQWT-----KDGLALGIGEDLRAWPRYRVLRLVDVGQYNLEI 86

  Fly    92 KNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIG 156
            .....: |:..:||    :.|.|.:......||||..|..|::......:.|...|..::|.|.|
Zfish    87 SAAELS-DDSLYEC----QATEAALRSRRAKLTVLIPPDEPVIEGSPEILLTAGVPYNMSCVSRG 146

  Fly   157 GSPDPMITWYREGSTVPLQ----SYALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEG 217
            ..|..:|.|.::|  :|::    :..:....|...|.:.|.|.|...|.|..:.||..|.|:|.|
Zfish   147 AKPASVIEWQKDG--LPIEGAVSTTEVLPDRKRVTTRSYLPIQPLDTDTGKNFTCVATNLAVPMG 209

  Fly   218 HMLETSVTLNVNYYPRV--EVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTH 280
            .  ..::||||::.|.|  .:.|::.|:.||   ....|:..|.|.:...:|::.|..:... ..
Zfish   210 K--RATITLNVHHPPVVTLSIEPRSVLEGER---VTFTCQATANPPIMGYKWAKGGVVIQGA-RE 268

  Fly   281 TIYRVNRHHA---GKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTA 342
            :::.....|:   ...:|...|.:|.| ...|::||.:.||:.:|.|....:....|.:.|....
Zfish   269 SVFVTKADHSFFTEPVSCQVFNAVGST-NVSILVDVHFGPILVVEPKPVTVDVDSDVTLNCKWAG 332

  Fly   343 NPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLV 407
            || |:.:.|.|:|:.........|.|.||....||.|:|:::       ..|: |||.:.|.|.|
Zfish   333 NP-PLTLTWTKKGSSMVLSNNNQLYLKSVSQADAGQYVCKAI-------VPRI-GVGETEVTLTV 388

  Fly   408 RHRPGQAYITPNKPVVHVGNG----VTLTCSANPPG----WPVPQYRWFRDMDGDIGNTQKILAQ 464
            ...|    |..::|..:...|    |....::.||.    |...:..|.:: .|.:.....:
Zfish   389 NGPP----IISSEPFQYAVRGERGEVKCYIASTPPPDKIVWAWKENVWEKE-KGTLSERYTV--- 445

  Fly   465 GPQYSIPKAHLGS---------------EGKYHCHAVNELGIGKIATIILEVHQPP--------- 505
              :.|.|.|..|:               :..|:|.|.|..|.|.:...:.|:...|
Zfish   446 --EQSKPSAQGGAVLSTLTINNIMESDFQSTYNCTAWNSFGSGTMIISLEEMEIVPVGIIAGGTV 508

  Fly   506 --------------QFLAKLQQHMTRRV-----------------------GDVDYA-------- 525
                          .||.:.::...|.|                       |.|..|
Zfish   509 GCSILLLLCLLALVLFLYRQRKGSRRGVTLGKPDIKVETINKESHSLEEDSGSVSTATRMVKAMY 573

  Fly   526 -----VTCSAKGKP-----------------TPQIRWIKDGTEILPTRKMFDIRTTPTDAG---- 564
                 ||.|...:|                 |.|...:||     ||...:::|.:..|.|
Zfish   574 SFLPSVTLSPSSQPFKDDIDLKQELRSDTLDTRQDYELKD-----PTNGYYNVRASTHDEGRPAS 633

  Fly   565 --------------GGVVAV----------------------------------------QSILR 575
                          ||..||                                        .|..:
Zfish   634 RSMHYSDYRTSSQPGGAAAVVSSSSGPPPGATAGPGTPSSLAPGSRAGCYDPRPPSRLSHNSYAQ 698

  Fly   576 FRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIE------HEPIVIHQYNKVAYDLRES 634
            |....|...:|..|...|..|..:..:.:..:||..|..|      |.|         .:.:..:
Zfish   699 FNTFTRAGQSQQPPPGSGPQTSDFPAECSLLDSSGQLGYENYGYPSHYP---------TFRMGFA 754

  Fly   635 AEVVCRVQAYPKPEFQWQYGNNPS---------PLTMSSDGHYEISTRMENNDVYTSILRIAHLQ 690
            ...:..::..|..|   .||..||         |.|  ..|.|..|||..    |||       |
Zfish   755 PPSLAPLEGGPAYE---MYGVGPSVGAGGGAGTPET--GLGKYGSSTRFS----YTS-------Q 803

  Fly   691 HSDY 694
            ||||
Zfish   804 HSDY 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	23/98 (23%)
		IG_like	141..228	CDD:214653	25/90 (28%)
		Ig	147..228	CDD:299845	24/84 (29%)
		I-set	232..313	CDD:254352	17/85 (20%)
		IGc2	250..302	CDD:197706	8/54 (15%)
		IG_like	323..385	CDD:214653	17/61 (28%)
		IGc2	330..385	CDD:197706	16/54 (30%)
		Ig_2	416..501	CDD:290606	19/107 (18%)
		IG_like	418..501	CDD:214653	18/105 (17%)
		I-set	505..612	CDD:254352	34/240 (14%)
		Ig	526..611	CDD:143165	26/159 (16%)
		IG_like	633..715	CDD:214653	21/71 (30%)
		Ig	635..713	CDD:143165	21/69 (30%)
		FN3	720..838	CDD:238020
kirrel1a	NP_001349348.1	I-set	21..115	CDD:333254	22/97 (23%)
		Ig2_KIRREL3-like	137..218	CDD:143236	24/84 (29%)
		I-set	222..303	CDD:333254	17/85 (20%)
		Ig_3	307..372	CDD:316449	20/65 (31%)
		Ig5_KIRREL3	390..493	CDD:143306	20/112 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840