DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and nrm

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	1560	Identity:	348/1560 - (22%)
Similarity:	527/1560 - (33%)	Gaps:	442/1560 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GIY--DLQIKNTSYNRDNGR-FECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAV----- 141
            |:|  .|::..|....|..: .|||:|:..        ..|:||........|.|.::.:
  Fly   219 GLYTSTLELDWTLSREDLAQDIECRVKSAA--------IQNVTVTKFSVDLQVRPTSIDINGVKH 275

  Fly   142 -ATEEKPLELTCSSIGGSPDPMITWYR--------EGSTVPLQSYALKGGSKNHYTNATLQIVPR 197
             ..:...:.|||...|..|...:|||.        |.....::|.:|:......:|.:.|.....
  Fly   276 HTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFNAT 340

  Fly   198 RADDGAKYKC------VVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDCRV 256
            |.::...::|      :..||..|    :.:::||.|.|.|.|:|.| :.:......:..|:|..
  Fly   341 RFENDRVFRCEAENIVLQINREKP----ISSALTLEVLYPPVVKVSP-SAITANTSEIVLLNCEY 400

  Fly   257 DAKP-MVSNVRWSRNGQYVSATPTHTIYR-------------VNRHHAGKYTCSADNGLGK-TGE 306
            .|.| .::.|.|.||...|:...| |.|:             ..:...|.|:|...|.:|| |.:
  Fly   401 FANPASLTQVEWYRNDILVNVNDT-THYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSD 464

  Fly   307 KDIVLDVLYPPIVFI----ESKTHEAEEGETVLIRCNV-TANPSPI-NVEW------LKEGAPDF 359
            :.|.|||.|.|.|.|    |....|::|....|. ||| .||||.: .|.|      ||| .||.
  Fly   465 QKINLDVQYAPTVEILMIPEGPVKESDESNVTLF-CNVLDANPSVLTKVRWYANSTLLKE-LPDC 527

  Fly   360 RYTGE--------LLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVG--NSTVALLVRHRPGQA 414
            ..|.|        .|.|.|:......||.|...|         ..|.|  :....|||.:.||.|
  Fly   528 EETREDLCHIDPSKLLLESIGRGFFYNYSCEGFN---------AAGWGPRSEDKELLVHYEPGPA 583

  Fly   415 YITPNKPVVHV-GNGVTLTCSANPPGWPVP-QYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGS 477
            .:: :.|:|.| ...||.:||.:.||:|.. ::||.|   |..|..|.|:.:  .:::....|.|
  Fly   584 ALS-HFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLR---GGRGPLQDIVTK--DWTVEPVGLDS 642

  Fly   478 EGKYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIK 542
            ...|.|:|.||.|.|.:||:.||||.||.|:..|..:........:..:||..:..|...|.|.|
  Fly   643 RTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSPNATLTCRIECVPRCDISWQK 707

  Fly   543 DGTEILPTRKMFDIRTTPTDAG---GGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDV- 603
            ||..|......:.|:....||.   |...::.|:|.|.....|:....:..|...|:|:...::
  Fly   708 DGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIEADNANYSCVSTGNIV 772

  Fly   604 -NSANSSMHLRIEHEPIVIHQYNKVAYDLRES--AEVVCRVQAYPKPEFQWQYGNNPSPLTMSSD 665
             .|..|..:..||:.|........:.|...::  ..|:|:.:|.|:|.::|.:.|.    |:::.
  Fly   773 GGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANPEPSYKWIFKNE----TIANG 833

  Fly   666 GHYEISTRMENND--VYTSILRIAHLQH------------------------SDYGEYICRAV-N 703
            ....|:|.|..||  .||.   :|:.:|                        .|....||.|. |
  Fly   834 NALIINTAMNRNDDGTYTC---LAYNKHGSSIAKTVIKVQFKPRCEIERQEIDDQDTLICTAYGN 895

  Fly   704 PLDSIRAPIRLQPKGSPEKPTNL----KILEVGHNYAVLNWTPGFNGGFMSTKYLVS--YRRVAT 762
            |   |.|......|...|...||    |...|..::.:|           .|.|.:|  ||.||
  Fly   896 P---IEADFSWSIKTENETDENLGSGKKENSVEKSFYIL-----------QTDYAISRTYRCVA- 945

  Fly   763 PREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFN--------------------CFKENPCKL- 806
              ..|:      ||.|..:|..:...:..:..|.|                    |.....|:.
  Fly   946 --NNTV------GYGPFCEIEVAEQLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRR 1002

  Fly   807 ---------APLDQHQSYMFKVYALNSKG----TSGYSNEILATTKVS-------KIPP------ 845
                     .|::..||.:.....::..|    |......||.....|       |.||
  Fly  1003 RRQDKYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPRWPIRP 1067

  Fly   846 --PLHVSYDPNSHVLGINVAATCLSLIAVVESLVTRDATV---------PMWEIVETLTLLPSGS 899
              .||||.:..                   |:|.....||         .|.::...|:...:||
  Fly  1068 GVMLHVSSNTK-------------------ENLTVNRMTVKPNVSGNRGDMSQLSAQLSAALNGS 1113

  Fly   900 ETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMALAETAGPGPVVRVKLCLRSNHE 964
            .......|:..:|        ..||.:          |...:::.|...     |.|..:.|...
  Fly  1114 RDNSDGTILTEIS--------AVSGEN----------EASNLSILEVTN-----RKKATVPSTIR 1155

  Fly   965 HCGAYANAEIGKSYMPHKSSMTTSA--LVAIIIASLSFV-----------VFLGLLYAFCHCRRK 1016
            :... |..||       .||.|.||  :....:.||.|.           ..:|||..|.    :
  Fly  1156 NVST-AEGEI-------ISSKTHSAGHIALDHVWSLIFKKSDDRTRDSQRSHVGLLQTFW----R 1208

  Fly  1017 HAAKKESSS------------VGGGVGGGNANATANPGSTGAKEYDLDLDASRRPSLSQDPQQSQ 1069
            ....|||:|            ..|.|....|..|.:..|..|...:..|  ::||:..| |..|.
  Fly  1209 GLGAKESTSGFESQHRLKGIRCSGSVTYKKAKETVHSTSDAASNGESSL--TKRPNNCQ-PSVSI 1270

  Fly  1070 QQPPPPPPYYPTGTLDSKDIGNGNGGMELTLTALHDPDEQLNMQQQQHHSNHGQYQQPKAILGIY 1134
            |.                                     |.||::          :..|.:|
  Fly  1271 QL-------------------------------------QSNMEE----------KTSKFVL--- 1285

  Fly  1135 GGVAGSGGNNSGGQHPHSNGYGYHVTSAIGVDSDSYQVLPSVANSAAGSHGHGSGHGHGLGAGES 1199
                ....|||..:                |::....::||:..                |:...
  Fly  1286 ----KDERNNSSTE----------------VENIPCNMVPSITR----------------GSSIE 1314

  Fly  1200 GPLEATP---PTCNI----SGGSSSNSGINPM-----QQQH----SARANLT------NQPTIAT 1242
            .|....|   |..|.    |.|.|.||.:.|.     :|.|    |.|..||      |.|....
  Fly  1315 SPQRPAPSSLPLKNFLNVTSWGCSGNSTMVPSHILANEQIHDKSSSLREPLTEPGEYENLPFHGL 1379

  Fly  1243 ASSTNNYNNHLNNTNIAHTTNNTNNCTTLKRGH--LGNRERER----ERCQVT-------AATAA 1294
            .::.|.::....|.|     ||||.....:|..  :||..:..    :.||.|       .....
  Fly  1380 QTAPNKFSTTPTNFN-----NNTNAVRVAQRPKELIGNINQPSVGLYQDCQATHDPLLYHQKYFC 1439

  Fly  1295 TTTAL---ATTITTTSRNAKAATTTTTLAITGSSSNSNENNYSNARDLSQEALWRLQMATAQSQQ 1356
            ...||   .:..||..|.........:| ....|:..:::|.||....|....::....:.:.|.
  Fly  1440 DQDALNDQRSQYTTMHRPPNNVQYNQSL-FKPDSNLQDQHNLSNCISKSYTEYYQQHQRSEKLQM 1503

  Fly  1357 IYVERPPSAFSGLVDYS----GYSPHIPTVTSSLSQQSFSPTQQLAPHEMLQAAQRYGTLRKSGK 1417
            |:   |..|...|...|    .::||...|..:|  :.:..|::.....|.:|..|.|||....|
  Fly  1504 IF---PQGASKELNSNSLCNTDHTPHSALVNINL--RKYDRTEEELLGNMPRARHRKGTLNVENK 1563

Fly 1418 1417
Fly 1564 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	11/43 (26%)
		IG_like	141..228	CDD:214653	20/106 (19%)
		Ig	147..228	CDD:299845	20/94 (21%)
		I-set	232..313	CDD:254352	25/95 (26%)
		IGc2	250..302	CDD:197706	16/65 (25%)
		IG_like	323..385	CDD:214653	25/77 (32%)
		IGc2	330..385	CDD:197706	24/70 (34%)
		Ig_2	416..501	CDD:290606	29/86 (34%)
		IG_like	418..501	CDD:214653	29/84 (35%)
		I-set	505..612	CDD:254352	25/111 (23%)
		Ig	526..611	CDD:143165	22/89 (25%)
		IG_like	633..715	CDD:214653	25/110 (23%)
		Ig	635..713	CDD:143165	25/104 (24%)
		FN3	720..838	CDD:238020	29/157 (18%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	9/28 (32%)
		Ig	277..354	CDD:299845	15/76 (20%)
		IG_like	383..463	CDD:214653	19/81 (23%)
		Ig	394..463	CDD:143165	18/69 (26%)
		Ig_3	585..652	CDD:290638	22/72 (31%)
		Ig	685..>719	CDD:299845	9/33 (27%)
		IG_like	788..869	CDD:214653	19/87 (22%)
		Ig	<811..869	CDD:299845	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810