DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and Kirrel1

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_006232737.1	Gene:	Kirrel1 / 310695	RGDID:	727883	Length:	805	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	184/839 - (21%)
Similarity:	304/839 - (36%)	Gaps:	230/839 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGAD 115
            :||     .:.:|:|   .::....||:......|.|:|:|.:...: |:..:||    :.|.|.
  Rat    84 QWT-----KDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELS-DDASYEC----QATEAA 138

  Fly   116 VHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGST---VPLQSY 177
            :......||||..|....:..|.:.:.....|..|||.:....|...|.|:|:|:.   ....:.
  Rat   139 LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTE 203

  Fly   178 ALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRV--EVGPQN 240
            .||.| |...|.:.|.|.|...|.|..:.|...|.|:|.|.  |||:.|:|::.|.|  .:.||.
  Rat   204 LLKDG-KRETTISQLLIQPTDLDIGRVFTCRSMNEAIPNGK--ETSIELDVHHPPTVTLSIEPQT 265

  Fly   241 PLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKY------------ 293
            .|:.||   ....|:..|.|.:...||::.|           :.:...|..:|
  Rat   266 VLEGER---VIFTCQATANPEILGYRWAKGG-----------FLIEDAHESRYETNVDYSFFTEP 316

  Fly   294 -TCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGA- 356
             :|...|.:|.|....:| :|.:.|.:.:..|....:.|..|.:.|....|| |:.:.|.|:.:
  Rat   317 VSCEVYNKVGSTNVSTLV-NVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSN 379

  Fly   357 ---------PDFRYTGELLT------LGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALL 406
                     |:...:.::|:      |.||....||.|.||::       ..|: ||....|.|.
  Rat   380 MGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAI-------VPRI-GVAEREVPLY 436

  Fly   407 VRHRPGQAYITPNKPVVHV--GNGVTLTC---SANPPGWPVPQYRW-FRDMDGDIGNTQKILAQG 465
            |...|    |..::.|...  |:|..:.|   |..||    .:..| :::...::|..::
  Rat   437 VNGPP----IISSEAVQFAVRGDGGKVECFIGSTPPP----DRIAWAWKENFLEVGTLER----- 488

  Fly   466 PQYSIPKAHLGS----------------EGKYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQH 514
              |::.:.:.||                :..|:|.|.|..|.|   |.|::          |::.
  Rat   489 --YTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPG---TAIIQ----------LEER 538

  Fly   515 MTRRVGDVDYAVTCSA-------------------KGKPTPQIRWIKDGTEILPTRKMFDIR--- 557
            ....||.:..| |..|                   ||..       ||.|    .||: ||:
  Rat   539 EVLPVGIIAGA-TIGAGILLVFSFAALVFFLYRRRKGSR-------KDVT----LRKL-DIKVET 590

  Fly   558 ------TTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSAN----SSMHL 612
                  |..:|......::.:..|..              :.:|:. :::||:...    .::..
  Rat   591 VNREPLTMHSDREDDTTSISTATRVM--------------KAIYSS-FKDDVDLKQDLHCDTIET 640

  Fly   613 RIEHE---PIVIHQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRM 674
            |.|:|   | ....||..|::.|.|:..|.             |.:..:|.....||  ..|:|:
  Rat   641 REEYEMKDP-TNGYYNVRAHEDRPSSRAVL-------------YADYRAPGPTRFDG--RPSSRL 689

  Fly   675 ENNDVYTSILRIAHLQHSDYGEYICRAVNPLDS-IRAPIRLQPKGSPEKPTNLKILEVGHNYAVL 738
            .::..|..:...:....||||      ..|..| ..||      |..:..:.|..    .||...
  Rat   690 SHSSGYAQLNTYSRAPASDYG------TEPTPSGPSAP------GGTDTTSQLSY----ENYEKF 738

  Fly   739 NWTPGFNGGFMSTKYLVSYRRV------ATPREQTLSDCSGNGYIPSYQISSSSSNSNH 791
            |..| |.|......|.:.|.:.      .||.|  ..|..|. |..:.:.|.:|.:|::
  Rat   739 NSHP-FPGAAGYPTYRLGYPQAPPSGLERTPYE--AYDPIGK-YATATRFSYTSQHSDY 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	17/74 (23%)
		IG_like	141..228	CDD:214653	28/89 (31%)
		Ig	147..228	CDD:299845	28/83 (34%)
		I-set	232..313	CDD:254352	20/95 (21%)
		IGc2	250..302	CDD:197706	10/64 (16%)
		IG_like	323..385	CDD:214653	19/77 (25%)
		IGc2	330..385	CDD:197706	18/70 (26%)
		Ig_2	416..501	CDD:290606	21/106 (20%)
		IG_like	418..501	CDD:214653	20/104 (19%)
		I-set	505..612	CDD:254352	21/138 (15%)
		Ig	526..611	CDD:143165	17/116 (15%)
		IG_like	633..715	CDD:214653	17/82 (21%)
		Ig	635..713	CDD:143165	16/78 (21%)
		FN3	720..838	CDD:238020	18/78 (23%)
Kirrel1	XP_006232737.1	I-set	54..148	CDD:254352	16/73 (22%)
		Ig	57..148	CDD:299845	16/73 (22%)
		Ig2_KIRREL3-like	170..251	CDD:143236	28/83 (34%)
		I-set	255..336	CDD:254352	20/95 (21%)
		Ig_2	259..337	CDD:290606	18/92 (20%)
		Ig_2	340..437	CDD:290606	25/105 (24%)
		IG_like	346..437	CDD:214653	24/99 (24%)
		Ig5_KIRREL3	439..536	CDD:143306	22/124 (18%)
		IG_like	451..536	CDD:214653	19/108 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840