DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and Kirrel2

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	508	Identity:	130/508 - (25%)
Similarity:	198/508 - (38%)	Gaps:	102/508 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGAD 115
            :||     .:.:|:|   |:...|.|.:....:.|.:||.||.... .|...:||:....|..:.
Mouse    52 QWT-----KDGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVEL-EDEASYECQASQAGLRSR 110

  Fly   116 VHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGS-PDPMITWYREGSTVPLQSY-- 177
            ..|    |.|:..|..|.|..|.........|..|||.|.|.| |.|.:.|:|:|..:...|:
Mouse   111 PAQ----LHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQ 171

  Fly   178 -ALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNP 241
             .||..:.....| ||.:.|...||||...|...::|:|.|.  :|:|||::.|.|.|.:..: |
Mouse   172 TTLKDKATGTVEN-TLFLTPSSHDDGATLICRARSQALPTGR--DTAVTLSLQYPPMVTLSAE-P 232

  Fly   242 LKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYV--SATPTHTIYRVNRHHAGKYTCSADNGLGKT 304
            ..|:........|:..|:|.|:..||::.|..|  :..|...:...........:|...|.:| :
Mouse   233 QTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVG-S 296

  Fly   305 GEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLG 369
            ..:...|:|||.||:..:.|:...:.|:.....|....||.| .:.|.:.|......:|..|.|.
Mouse   297 ANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRGNPLP-RITWTRMGGSQVLSSGPTLRLP 360

  Fly   370 SVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCS 434
            ||..|.||:|:||:    :|    |..|:|..         ..||.:|.|.|.|       :|..
Mouse   361 SVALEDAGDYVCRA----EP----RRTGLGGG---------KAQARLTVNAPPV-------VTAL 401

  Fly   435 ANPPGW--------------PVP-QYRWFRDMDG--DIGNTQKIL-----------AQGPQYSIP 471
            ...|.:              |.| ...|..| :|  :.|:..:.|           .|||.. |.
Mouse   402 QPAPAFLRGPARLQCVVFASPAPDSVVWSWD-EGFLEAGSLGRFLVEAFPAPEVEGGQGPGL-IS 464

  Fly   472 KAHLGSEGK------YHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRR 518
            ..|:....:      ::|.|.|.||.|::                 |.|:.||
Mouse   465 VLHISGTQESDFTTGFNCSARNRLGEGRV-----------------QIHLGRR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	18/74 (24%)
		IG_like	141..228	CDD:214653	31/90 (34%)
		Ig	147..228	CDD:299845	31/84 (37%)
		I-set	232..313	CDD:254352	17/82 (21%)
		IGc2	250..302	CDD:197706	11/53 (21%)
		IG_like	323..385	CDD:214653	19/61 (31%)
		IGc2	330..385	CDD:197706	18/54 (33%)
		Ig_2	416..501	CDD:290606	24/118 (20%)
		IG_like	418..501	CDD:214653	23/116 (20%)
		I-set	505..612	CDD:254352	4/14 (29%)
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	18/73 (25%)
		Ig	122..220	CDD:416386	34/100 (34%)
		Ig strand A	123..126	CDD:409353	1/2 (50%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	1/1 (100%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	3/8 (38%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	2/7 (29%)
		Ig_3	223..292	CDD:404760	14/69 (20%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	1/8 (13%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	25/94 (27%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	1/8 (13%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	1/1 (100%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	1/4 (25%)
		Ig strand F	368..376	CDD:409353	4/11 (36%)
		Ig strand G	382..392	CDD:409353	3/18 (17%)
		Ig	394..498	CDD:416386	24/129 (19%)
		Ig strand A	395..399	CDD:409353	2/10 (20%)
		Ig strand A'	401..404	CDD:409353	0/2 (0%)
		Ig strand B	412..419	CDD:409353	0/6 (0%)
		Ig strand C	426..431	CDD:409353	1/4 (25%)
		Ig strand C'	433..436	CDD:409353	1/2 (50%)
		Ig strand D	444..451	CDD:409353	1/6 (17%)
		Ig strand E	461..468	CDD:409353	1/7 (14%)
		Ig strand F	479..486	CDD:409353	2/6 (33%)
		Ig strand G	489..496	CDD:409353	3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840