DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and igcm-2

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	1039	Identity:	217/1039 - (20%)
Similarity:	342/1039 - (32%)	Gaps:	359/1039 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 PLELTCS-SIGGSPDPMITWYREGSTVPLQSYALKGGSKNHYTNATLQIVPRRADDG-------- 202
            |:.|.|| |:.......:.|.::|..: |.::   |..:.|.| .|||  .|.|.||
Worm    30 PITLPCSISLFNEESFSLDWRKDGQLI-LSAF---GQEQGHVT-PTLQ--GRLARDGFLGITIHS 87

  Fly   203 ------AKYKCVVW----NRAMPEGHMLETSVTLNVNYYPRVEVGP-QNPL---KVERDHVAKLD 253
                  ..|:|:|.    ....|| ..|...:.:||   |.|.:.| :|.:   ||..|.:  .:
Worm    88 VTDGDAGVYQCIVTKFSKQPTRPE-KGLSAKLVVNV---PPVIISPSKNAIIHKKVGADLI--FE 146

  Fly   254 CRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSADNGLG-KTGEKDI------VL 311
            |:.:..|. ..:.||||.|.:|.:|..|:..:.....|.|||.|.|..| .|...|:      :|
Worm   147 CKAEGAPS-PEITWSRNEQIISTSPVLTLSNLEEGDKGLYTCLAVNIEGNSTSSIDVRFTKATIL 210

  Fly   312 DVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAP----------DFRYTGELL 366
            |::  |:    :||  ..||..|...|:..|..:.|:..||.|..|          :.| :|: |
Worm   211 DLI--PL----NKT--VIEGSNVFWHCHANAQATAISYSWLFEKKPIKTTSLGLRSNIR-SGD-L 265

  Fly   367 TLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTL 431
            :|..||...:|.|.|.:.|.....:|        ||..|.|.:.|..  ::.::||..|.:|...
Worm   266 SLQDVRKSDSGWYTCEAKNSAGETTS--------STAYLHVFYPPEP--LSSHQPVQTVASGRNT 320

  Fly   432 TCSANPPGWPVP-QYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELGIGKIA 495
            |.|.:....|.| .|.|.:  :|....||    ......|..|..|..|.|.|.|.|..|.|.|.
Worm   321 TVSCDVIANPTPTSYTWSK--NGHYLPTQ----ASSHIIISYAKPGDGGIYGCQADNIAGKGSIV 379

  Fly   496 TIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIKDGTEILPTRKMFDIRTTP 560
            ...|.|.:||.|.......:..|:|| ..::.|...|.|.|.:.||:|...|
Worm   380 ETHLIVAEPPVFTVAPPSEIKVRLGD-QVSIPCQGFGDPMPIVYWIRDKKRI------------- 430

  Fly   561 TDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYN 625

Worm   431 ----------------------------------------------------------------- 430

  Fly   626 KVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQ 690
                                          |.|.||...                        ::
Worm   431 ------------------------------NQSTLTFKK------------------------VE 441

  Fly   691 HSDYGEYICRAVNPLDSIRAPIRLQPK-GSPEKPTNLKILEVGHNYAVLNWTPGFNGGFMSTKYL 754
            |.|:|.|.|...|.:::|...:.|..: ..|:..:::|...:..:...::||||:||||
Worm   442 HLDHGAYECVVANSVETISTRVMLLVEITKPQMASSIKFTCLNSSSMRISWTPGYNGGF------ 500

  Fly   755 VSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENPCKLAPLDQHQSYMFKV 819
                      :||.:..:.|.....:   :|...|.:|.|           |..|:...||...:
Worm   501 ----------DQTFAVHAQNDVTLQW---TSIKTSLNETI-----------LDHLEPFVSYRVSI 541

  Fly   820 YALNSKGTSGYSNEILATTKVSKIPPPLHVSYDPNS-HVLGIN----VAATCLSLIAVVESLVTR 879
            .::|:||::.      :||...:....||.   |:. :..|.|    .||...|...:.......
Worm   542 ESVNAKGSTN------STTYNRRSCTSLHA---PDKLYFCGYNELCWTAAEGASSYRIESRTEPS 597

  Fly   880 DATVPMWEIVETLTLLPSGSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMALA 944
            ....|:.|::||                        :|                .||:|    :.
Worm   598 KNFQPLAEVLET------------------------YY----------------RLGKD----VD 618

  Fly   945 ETAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKSSMTTSALVAIIIASLSFVVFL----- 1004
            ||  ...:.||    ||..            .||.|.:.|   :||...|..::...:|:
Worm   619 ET--KQTIFRV----RSTR------------PSYPPSEPS---NALRYGIADNVDLPIFMLAAVF 662

  Fly  1005 GLLYAFC---------HCRRKHAAKKESSSVG---------GGVGGGNANATANPGSTGAKEYDL 1051
            |||:.|.         |.:.|.:.:::|.|..         |....|:.::::.||:....|..|
Worm   663 GLLFCFACGLFAWRCFHNKNKKSKRRKSRSNSTPSKTYQDYGRFTYGDGSSSSQPGTETYYEPSL 727

  Fly  1052 DLDASRRPSLSQDPQQSQQQPPPPPPYYPTGTLD-SKDIGNGNGGMEL----TLTALHDPDEQL 1110
            .|       |.....:..:...|....||....: ..|||..:...::    .:..:.||..||
Worm   728 RL-------LDDHEWRGPRDLEPVAVRYPPSLAELDYDIGEDHPIDDMFRDRYILGVQDPPAQL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653	24/99 (24%)
		Ig	147..228	CDD:299845	24/99 (24%)
		I-set	232..313	CDD:254352	27/91 (30%)
		IGc2	250..302	CDD:197706	16/51 (31%)
		IG_like	323..385	CDD:214653	21/71 (30%)
		IGc2	330..385	CDD:197706	19/64 (30%)
		Ig_2	416..501	CDD:290606	25/85 (29%)
		IG_like	418..501	CDD:214653	25/83 (30%)
		I-set	505..612	CDD:254352	13/106 (12%)
		Ig	526..611	CDD:143165	8/84 (10%)
		IG_like	633..715	CDD:214653	11/81 (14%)
		Ig	635..713	CDD:143165	11/77 (14%)
		FN3	720..838	CDD:238020	24/117 (21%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	20/77 (26%)
		Ig	124..200	CDD:386229	24/78 (31%)
		IG_like	214..298	CDD:214653	27/99 (27%)
		Ig_3	309..371	CDD:372822	20/67 (30%)
		Ig	389..467	CDD:386229	25/210 (12%)
		FN3	476..548	CDD:238020	21/101 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010