Protein Alignment fred and LOC1278969

DIOPT Version :10

• Sequence 1: NP_608812.3
• Gene: fred / 33613
• FlyBaseID: FBgn0051774
• Length: 1447
• Species: Drosophila melanogaster
• Sequence 2: XP_061512275.1
• Gene: LOC1278969 / 1278969
• VectorBaseID: AGAMI1_012658
• Length: 898
• Species: Anopheles gambiae
• Alignment Length: 905
• Identity: 185/905 - (20%)
• Similarity: 286/905 - (31%)
• Gaps: 318/905 - (35%)

  Fly    12 LW----LSIGLISGDD----------SLDTREGVDLVLKCRFT----EHY------DSTDFTFYW 52
            ||    |.|.||.|..          |::..||..:.|.|..|    :.|      |:.....|.
Mosquito    10 LWWKLVLIINLIDGKSMHEKDKHDVFSVEGVEGRSVELHCPITVPLSQVYMVLWFKDNAGIPLYS 74

  Fly    53 -----------ARWTCCPTLFENVAIGDVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECR 106
                       |.|: .|.:|.:        .:.:.:|..|:    .|.|||.. ..|.|.:.||
Mosquito    75 VDVRDKISRQPAHWS-APEVFGS--------RAKFNIDKSPA----SLLIKNLK-RHDQGVYRCR 125

  Fly   107 IKAKGTGADVHQEFYNLTVLTAPHPPMVTP--GNLAVATEEKPLE------LTCSSIGGSPDPMI 163
            |..:......::  |||:|:..|..|:|..  |.....|:..|.|      :||...||.|.|.:
Mosquito   126 IDFRTIQTQTYR--YNLSVIVLPEQPVVLDRWGRHLNGTKLGPKEEGDDVVITCRVSGGRPQPEV 188

  Fly   164 TWYREGSTVPLQSYALKGGS--KNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTL 226
            .|...|..|..| |....|.  :|.....|:|    |:|..|.:.|...|..:.|..  |||..|
Mosquito   189 RWLINGVIVDDQ-YEQNSGDVIENRLLWPTIQ----RSDLNAIFTCQTMNTKLVEPK--ETSYVL 246

  Fly   227 NVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTI--------- 282
            :::..|........|..:..|...::.|:.......:.:.|.:..:.:..|...|:
Mosquito   247 DMHLKPLTIKVINPPATLVADKRYEIVCQSTGSRPNAIITWYKGKRQMRRTRDETVDHNTTTSTL 311

  Fly   283 -YRVNRHHAGK-YTCSAD----NGLGKTGEKDIVLDVLYPPIVFIE----SKTHEAEEGETVLIR 337
             :.......|| .||.|:    |||..  |.|..::|:|||:|.|:    ....:.:||:.|...
Mosquito   312 SFAPTTEDDGKTLTCRAENPNVNGLFL--ETDWKMNVVYPPMVTIQLGPTLVVDDIKEGDDVYFE 374

  Fly   338 CNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNST 402
            |:|.|||....::|.....                             ::|...|.|:...|.|.
Mosquito   375 CHVRANPDWKRLQWFHNDV-----------------------------LLQYNGSARIIQSGQSL 410

  Fly   403 VALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQ 467
            |                                                      .||:..|
Mosquito   411 V------------------------------------------------------LQKVTKQ--- 418

  Fly   468 YSIPKAHLGSEGKYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKG 532
                     |.|.|.|.|:|..|    .|:            ..|||:.     |.:...|:
Mosquito   419 ---------SAGYYACSAINAEG----ETV------------SDQQHLR-----VKHVPVCA--- 450

  Fly   533 KPTPQIRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTC 597
                                        |:..||             ..|.||
Mosquito   451 ----------------------------TERHGG-------------NAPGGN------------ 462

  Fly   598 LYENDVNSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQAYPKP-EFQWQYGNNPSPLT 661
              ..|.:.:|.:..|              :.....|:.|:.|.:.|.|.. .|.|::.|:...|.
Mosquito   463 --GTDPSGSNRNAIL--------------IGASRNENVEIPCHIFADPPARSFHWRFNNSAEILP 511

  Fly   662 MSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICRAVNPLDSIRAP--IRLQPKGSPEKPT 724
            :  |.|...|   :.|   .|||..|.:...|:|...|.|||.:.....|  .:|.....|...:
Mosquito   512 V--DAHRYTS---QGN---ISILNYAPVTDQDFGTLTCWAVNEVGPQSQPCTFQLVLADLPSPVS 568

  Fly   725 NLKILEVGHNYAVLNWTPGFNGGF--MSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSS 787
            |..:......:|.:..|||::||.  :....||| :|..|.|                   .:.|
Mosquito   569 NCSLPNRTQQFAEIQCTPGYDGGLPQVFVLELVS-KRTGTRR-------------------FNFS 613

  Fly   788 NSNHEWIEFNCFKENPCKLAPLD--QHQSYMFKVYALNSKGTSGYSNEILATTKVSKIPP 845
            |.|..:...:..:    ||:.|.  ::.|....|||:|.||.|  :..::...::.:|.|
Mosquito   614 NKNEPFFVLDRLE----KLSALMTLENNSLSCVVYAINQKGRS--TPVLIQDFEIGRIQP 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	132..228	CDD:472250	31/105 (30%)
		Ig strand B	148..152	CDD:409353	1/9 (11%)
		Ig strand C	162..166	CDD:409353	0/3 (0%)
		Ig strand E	190..194	CDD:409353	1/3 (33%)
		Ig strand F	204..209	CDD:409353	1/4 (25%)
		Ig strand G	221..224	CDD:409353	2/2 (100%)
		Ig	238..313	CDD:472250	16/89 (18%)
		Ig strand B	250..254	CDD:409353	0/3 (0%)
		Ig strand C	264..268	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	0/3 (0%)
		Ig strand F	292..297	CDD:409353	3/5 (60%)
		Ig strand G	306..309	CDD:409353	1/2 (50%)
		Ig_3	316..385	CDD:464046	13/72 (18%)
		Ig_2	416..501	CDD:464026	11/84 (13%)
		Ig	523..614	CDD:472250	10/90 (11%)
		Ig strand B	524..528	CDD:409568	0/3 (0%)
		Ig strand C	537..541	CDD:409568	0/3 (0%)
		Ig strand E	566..570	CDD:409568	1/3 (33%)
		Ig strand F	594..599	CDD:409568	0/4 (0%)
		Ig strand G	607..610	CDD:409568	1/2 (50%)
		Ig_3	618..703	CDD:464046	21/85 (25%)
		FN3	720..838	CDD:238020	28/121 (23%)
LOC1278969	XP_061512275.1	None