DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and LOC110439987

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_021333826.1	Gene:	LOC110439987 / 110439987	-ID:	-	Length:	725	Species:	Danio rerio

Alignment Length:	776	Identity:	183/776 - (23%)
Similarity:	291/776 - (37%)	Gaps:	174/776 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKLLIIGQL----WLSIGLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFEN 64
            |.||||.::    |   |:......:...:...:.:.|.||  |.:|.:......|.  ..|.:|
Zfish    14 IFLLIIHRVSAAGW---GVNYSPSQICALQNSSVTISCTFT--YPTTGYQIMKVFWN--KDLVKN 71

  Fly    65 VA-----------------IGDVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGT 112
            ..                 :||.:.|...||..         ..||     |...:..||....|
Zfish    72 GGEFADLSEDPEYSQRLQYLGDKKQNCTIRLSH---------VTKN-----DEHEYYFRITTNVT 122

  Fly   113 GA------DVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCS-SIGGSPDPMITWYREGS 170
            |.      .||   .|:|.|....|..||.|:        .:.|||. |...:..|...|||
Zfish   123 GGRIIGIPGVH---LNVTDLQLESPERVTEGD--------SVRLTCKRSCNLTDTPTFIWYR--- 173

  Fly   171 TVPLQSYALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNR--AMPEGHMLETSVTLNVNYYP- 232
                .|..|..|:    |...|.:.|.|.:|..:|:|.|...  |.|:       |.|||.|.|
Zfish   174 ----NSEILTTGT----TGDKLILDPVRGEDAGRYRCAVLGNTLASPD-------VYLNVTYPPN 223

  Fly   233 RVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSA 297
            .|.|.......:.:.....|.|..::.|...|..|.:....|.:.....|.:::...:|:|.|.|
Zfish   224 NVSVSINGSAVIVKGDSVSLICSSNSNPPALNFSWFKGETSVGSGRIFNISKISSDDSGEYKCRA 288

  Fly   298 DNGLGKTGEKDIVLDVLYPP--IVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFR 360
            .|.||:.....:.|||.|||  :.....::.....|::|.:.|:..:|| |....|.|  ...:.
Zfish   289 RNDLGEKYSAPVTLDVQYPPRNVSISIRRSAVIMSGDSVTLNCSSDSNP-PALFSWFK--GTTYV 350

  Fly   361 YTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNS-TVALLVRHRPGQAYITPNKP-VV 423
            .:|.:..:.::.::.:|.|.|:         :|...||..| .|.|..::.|....::.:.| |:
Zfish   351 GSGRIFNILNISSDDSGEYKCK---------AKNEHGVKYSDPVTLDAQYPPRNISVSISGPAVI 406

  Fly   424 HVGNGVTLTCS--ANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAV 486
            ..|:.|||:||  :|||..   .:.||:      |:|.  :..|..:||.|......|:|.|.|.
Zfish   407 MSGDSVTLSCSSDSNPPAL---NFSWFK------GDTS--VGSGRIFSISKISSDDSGEYKCRAK 460

  Fly   487 NELGIGKIATIILEVHQPPQFLA-KLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIKDGTEILPT 550
            |:.|......:.|:|...|:.:: .:........|| ...:.||:...|..:|.|.| |...:.:
Zfish   461 NDHGEKYSDPVTLDVQYAPRNISVSISGSAVIMSGD-SVTLNCSSDSNPPAEINWFK-GETFVGS 523

  Fly   551 RKMFDIRTTPTDAGGG-----------------VVAVQSILR---------FRGKARP------N 583
            .::|:|....:|..|.                 .:.|||:.:         |:|:...      |
Zfish   524 GRIFNISKISSDDSGEYKCRARNEHGEEYSDPVTLDVQSVTQTLPPAEISWFKGETSVGSGRFFN 588

  Fly   584 GNQLLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIH-QY--NKVAYDLRESAEVVCRVQAYP 645
            .:::..:|.|.|.|...|        .|.....:|:.:. ||  ..::..:..|..|:.
Zfish   589 ISKISSDDSGEYKCRARN--------AHGEKYSDPVTLDVQYPPRNISVSVSGSHVVMS------ 639

  Fly   646 KPEFQWQYGNNPSPLTMSSDGH--YEISTRMENNDVYTS-ILRIAHLQHSDYGEYICRAVN 703
                    |::.| |..|||.:  .|||...|.:.|.:. |..|..:...|.|||.|||.|
Zfish   640 --------GDSVS-LNCSSDSNPPAEISWFKEESFVGSGRIFNIPKISSDDSGEYKCRARN 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	24/119 (20%)
		IG_like	141..228	CDD:214653	23/89 (26%)
		Ig	147..228	CDD:299845	23/83 (28%)
		I-set	232..313	CDD:254352	18/81 (22%)
		IGc2	250..302	CDD:197706	12/51 (24%)
		IG_like	323..385	CDD:214653	12/61 (20%)
		IGc2	330..385	CDD:197706	12/54 (22%)
		Ig_2	416..501	CDD:290606	26/87 (30%)
		IG_like	418..501	CDD:214653	26/85 (31%)
		I-set	505..612	CDD:254352	25/139 (18%)
		Ig	526..611	CDD:143165	22/116 (19%)
		IG_like	633..715	CDD:214653	23/74 (31%)
		Ig	635..713	CDD:143165	22/72 (31%)
		FN3	720..838	CDD:238020
LOC110439987	XP_021333826.1	V-set	31..137	CDD:311561	23/126 (18%)
		IGc2	149..202	CDD:197706	18/71 (25%)
		Ig_2	232..304	CDD:316418	15/71 (21%)
		Ig_2	318..387	CDD:316418	17/80 (21%)
		Ig_2	403..475	CDD:316418	26/82 (32%)
		Ig_2	489..560	CDD:316418	13/72 (18%)
		Ig_2	<568..620	CDD:316418	10/59 (17%)
		Ig_2	640..705	CDD:316418	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920