DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and MALT1

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_006776.1	Gene:	MALT1 / 10892	HGNCID:	6819	Length:	824	Species:	Homo sapiens

Alignment Length:	818	Identity:	167/818 - (20%)
Similarity:	257/818 - (31%)	Gaps:	284/818 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 VLDVLYPPIVFI----ESKTHEAEEGETVLIRCNVTANPSPINVEWLK--EGAPDFRYTGELLTL 368
            ||.:|.||.:.|    |||...|  |:.|.:.|..|.:|. :..:|.|  :..|:.. |.||: .
Human   118 VLQLLSPPGIKITVNPESKAVLA--GQFVKLCCRATGHPF-VQYQWFKMNKEIPNGN-TSELI-F 177

  Fly   369 GSVRAEHAGNYICRSVN----------------IMQPFSSKRVEGVGNSTVALLVRHRPGQAYIT 417
            .:|..:.||.|:||..|                |.:.| .:.|:||..|.:         |..:.
Human   178 NAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESF-QRSVDGVSESKL---------QICVE 232

  Fly   418 PNKPVVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYH 482
            |....:..|:.:.|.|.|  .|.|:|.|:||::.......|:|:      |.:|...|..:|.|.
Human   233 PTSQKLMPGSTLVLQCVA--VGSPIPHYQWFKNELPLTHETKKL------YMVPYVDLEHQGTYW 289

  Fly   483 CHAVNELGI--GKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAK-----GKP-----T 535
            ||..|:...  .|...||                    :|..|.||.|:..     |.|     |
Human   290 CHVYNDRDSQDSKKVEII--------------------IGRTDEAVECTEDELNNLGHPDNKEQT 334

  Fly   536 PQIRWIKDGTEIL--------------PTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQ 586
            ......||...:|              |...::::..........||::..:..:..:...: ..
Human   335 TDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVD-EF 398

  Fly   587 LLPNDRGLYTCLYENDVNSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQAYPKPEFQW 651
            ||..|:|:|..||                        |....|:
Human   399 LLLLDKGVYGLLY------------------------YAGHGYE--------------------- 418

  Fly   652 QYGNN-------PSPLTMSSDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYI-----CRAVNP 704
            .:||:       |:|.            |.||.....:||::  :|..:.|..:     ||..|.
Human   419 NFGNSFMVPVDAPNPY------------RSENCLCVQNILKL--MQEKETGLNVFLLDMCRKRND 469

  Fly   705 LDSIRAPIRLQPKGSPEKPTNLKILEVGHN----YAVLNWTPGF--------NGGFM-------- 749
            .|. ..||             |..|:|..|    ||.......|        ||.||
Human   470 YDD-TIPI-------------LDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLL 520

  Fly   750 -STKYLVSYRRVA--------TPREQTLSDCSG-------NGYIPSYQISSSSSNSNHEWIEFNC 798
             ..|..|....||        |..:|.|...|.       ...|...:.|:.|...|.:|.:.:.
Human   521 EDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHE 585

  Fly   799 FKENPCKLAPLDQHQSYMFKVYALNSKGTSGYSNEILATTKVSKIPP------------PLHVSY 851
            ..|:.|............|         .:.:||.::..|.:...||            ||.:..
Human   586 LPESMCLKFDCGVQIQLGF---------AAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDI 641

  Fly   852 DP-----------NSHVLGINVAATCL-----SLIAVVESLV-----------TRDATVPMWEIV 889
            ||           .|:::..::...||     ||..:.|.||           ..|......|:.
Human   642 DPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVN 706

  Fly   890 ETLTLLPS-------GSETTFKEAIINHVSRPAHYTTATTSGRSLGVGGGSHLGEDRTMAL--AE 945
            ....|:..       |.:|.|:..:   :|...:.::|.|||.:    |..|..:|....:  :.
Human   707 VGKPLIAKLDMHRGLGRKTCFQTCL---MSNGPYQSSAATSGGA----GHYHSLQDPFHGVYHSH 764

  Fly   946 TAGPGPVVRVKLCLRSNHEHCGAYANAEIGKSYMPHKS 983
            ...|..|.....|      ||....:|.| .|:..|.|
Human   765 PGNPSNVTPADSC------HCSRTPDAFI-SSFAHHAS 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653
		Ig	147..228	CDD:299845
		I-set	232..313	CDD:254352	2/2 (100%)
		IGc2	250..302	CDD:197706
		IG_like	323..385	CDD:214653	20/63 (32%)
		IGc2	330..385	CDD:197706	17/56 (30%)
		Ig_2	416..501	CDD:290606	24/86 (28%)
		IG_like	418..501	CDD:214653	24/84 (29%)
		I-set	505..612	CDD:254352	21/130 (16%)
		Ig	526..611	CDD:143165	18/108 (17%)
		IG_like	633..715	CDD:214653	17/93 (18%)
		Ig	635..713	CDD:143165	16/89 (18%)
		FN3	720..838	CDD:238020	29/153 (19%)
MALT1	NP_006776.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Death_MALT1	42..126	CDD:260053	4/7 (57%)
		Ig_2	128..194	CDD:290606	22/70 (31%)
		IG_like	133..201	CDD:214653	22/72 (31%)
		Ig_2	232..308	CDD:290606	24/103 (23%)
		I-set	233..308	CDD:254352	24/102 (24%)
		Peptidase_C14	343..560	CDD:279049	49/290 (17%)
		Caspase-like	348..562		48/287 (17%)
		Nuclear export signal	369..376		0/6 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7699
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950