DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and LOC108183407

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_021330937.1	Gene:	LOC108183407 / 108183407	-ID:	-	Length:	495	Species:	Danio rerio

Alignment Length:	444	Identity:	89/444 - (20%)
Similarity:	138/444 - (31%)	Gaps:	175/444 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISGDDSLDTREGVDLVLKCRF--TEHYD---STDFTFYWARWTCCPTLFENVAIGDVQLNSNYRL 78
            ||..:.:....|..:|:||||  .:.||   :.....||         |::      ..|.:..|
Zfish    30 ISLPEKIQALSGSCVVIKCRFDINDTYDKNLTERAAGYW---------FKS------GTNVDKNL 79

  Fly    79 DFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVAT 143
            .|..|..:.:|.||.            :|..|.|..|....||.:|        .:..|......
Zfish    80 IFNSSESMQNLFIKG------------KITGKLTDKDCTTVFYEVT--------SIHSGQYMFRI 124

  Fly   144 EEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYALKGGSKNHYTNATLQIVPRRADDGAKYKCV 208
            |.                                  :||.|..|.
Zfish   125 EG----------------------------------EGGLKWTYN-------------------- 135

  Fly   209 VWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNP---LKVERDHV---------AKLDCRVDAKPM 261
                        :|:|:|:|     :| .|.||   |.|::..:         ..:..|..|:.:
Zfish   136 ------------KTNVSLDV-----IE-SPMNPRVVLYVDKQELQGQQEVLEGRSVSLRCSAETL 182

  Fly   262 VSN----VRWSRNGQYVSATPTHTIYRVN---------RHHAGKYTCS-----ADNGLGKTGEKD 308
            .|:    :.||...:.:.:..:.....:|         |||...:|||     .||  .:|....
Zfish   183 CSSPPATLTWSSTARILLSESSKLQELINSDLNFTAARRHHRVTFTCSISYQLQDN--NRTAHSS 245

  Fly   309 IVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEG-----APDFRYTGELLTL 368
            |.|.|.|.|.:...|    ...|...:..|.|..||||: |||...|     :.:...:.|.|:.
Zfish   246 ITLHVQYAPQILNSS----CNIGNVTVCFCEVDGNPSPV-VEWHLSGRLILNSSNTFISEERLSN 305

  Fly   369 GSVRA--------EHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQA 414
            .|:|:        .|....:|.|.|.:           ||:  :.|.:|.|..|
Zfish   306 TSLRSVISLHQSLTHTNTLLCVSKNTL-----------GNA--SHLFQHLPSTA 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	25/101 (25%)
		IG_like	141..228	CDD:214653	8/86 (9%)
		Ig	147..228	CDD:299845	7/80 (9%)
		I-set	232..313	CDD:254352	23/110 (21%)
		IGc2	250..302	CDD:197706	14/69 (20%)
		IG_like	323..385	CDD:214653	19/74 (26%)
		IGc2	330..385	CDD:197706	18/67 (27%)
		Ig_2	416..501	CDD:290606
		IG_like	418..501	CDD:214653
		I-set	505..612	CDD:254352
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
LOC108183407	XP_021330937.1	Ig	28..142	CDD:325142	35/212 (17%)
		Ig_3	165..232	CDD:316449	12/66 (18%)
		Ig	250..335	CDD:325142	24/100 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010