DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fred and zmp:0000000650

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:XP_017210802.1 Gene:zmp:0000000650 / 100538209 ZFINID:ZDB-GENE-130530-653 Length:577 Species:Danio rerio


Alignment Length:443 Identity:102/443 - (23%)
Similarity:168/443 - (37%) Gaps:87/443 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 DSLDTREGVDLVLKCRFTEHYDSTDFTFYWARWTCCPTLFENVAIG-------DVQLNSNYRLDF 80
            :.::...|..::::||| |.....|           ..|.|..|:|       :|..:.:::.|.
Zfish    28 EKIEALSGSCVIIECRF-EIVPEMD-----------KYLTEENAVGFWFNGKKEVFHSKHHKADH 80

  Fly    81 ---RPSRGIYDLQIKNTSYN---RDNGRFECRIKAKGTGADV----HQEFYNLTVLTAPHPPMVT 135
               ..|..:::.......||   ..|.:|..||::...|..:    :::...:.|:.:|..|.:.
Zfish    81 FEGTMSEKLHEKNCTTVFYNVGSDHNNKFYFRIESTVNGIGLKYSYNKKLSTINVVESPVNPRIV 145

  Fly   136 --PGNLAVATEEKPLE-----LTCS--SIGGSPDPMITWYREGSTVPLQSYALKG--GSKNHYTN 189
              .....:..:::.||     |.||  ::...|...:||...|..:..:|..|:.  .|..::|.
Zfish   146 LYEDEQELQDQQEVLEGRSVSLRCSAETLCSIPPATLTWSSAGKILLSESSKLQELVVSALNFTA 210

  Fly   190 ATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPR---VEVGPQNPLKVERDHVAK 251
            |     ||.  ....:.|.:..:.........:|:.|:|.|.|:   |.|.|.|.:.|  .|...
Zfish   211 A-----PRH--HRVTFTCSISYQLQDNNKTARSSIPLHVQYSPKNTSVSVFPSNSVLV--GHSVT 266

  Fly   252 LDCRVDAKPMVSNVRWSR--NGQ--YVSATPTHTIYRVNRHHAGKYTCSADNGLGKTGEKDIVLD 312
            |.|..:|.|.|....|||  .||  .:....|.|.......|:|.|.|:|.|..| |..|.::||
Zfish   267 LTCSSEANPAVLIYSWSRETKGQLEMLQTGETLTFNETALSHSGLYICTAQNKHG-TQTKAVMLD 330

  Fly   313 VLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGS---VRAE 374
            :.|.|  .|.|.:.....|.|... |.|..||.| .|||        ..:|.|::...   :..:
Zfish   331 IQYVP--QISSSSSCTSTGVTECF-CEVDGNPYP-EVEW--------HLSGHLVSNSPNTFISEK 383

  Fly   375 HAGNYICRSVNIMQPFS-------SKRVEGVGNSTVALLVRHRPGQAYITPNK 420
            ...|...|||..:|..:       ||...|..:....|:        :||.|:
Zfish   384 RLSNTSLRSVISLQSLTHNSLLCVSKNAHGNASQLFYLV--------FITENE 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 20/113 (18%)
IG_like 141..228 CDD:214653 19/95 (20%)
Ig 147..228 CDD:299845 19/89 (21%)
I-set 232..313 CDD:254352 29/87 (33%)
IGc2 250..302 CDD:197706 18/55 (33%)
IG_like 323..385 CDD:214653 16/64 (25%)
IGc2 330..385 CDD:197706 15/57 (26%)
Ig_2 416..501 CDD:290606 3/5 (60%)
IG_like 418..501 CDD:214653 1/3 (33%)
I-set 505..612 CDD:254352
Ig 526..611 CDD:143165
IG_like 633..715 CDD:214653
Ig 635..713 CDD:143165
FN3 720..838 CDD:238020
zmp:0000000650XP_017210802.1 Ig 22..126 CDD:299845 20/109 (18%)
Ig 152..228 CDD:299845 17/82 (21%)
IG_like 255..329 CDD:214653 25/76 (33%)
IGc2 262..321 CDD:197706 19/58 (33%)
Ig 353..415 CDD:299845 18/70 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35531at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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