DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and LOC100536326

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_021325377.1	Gene:	LOC100536326 / 100536326	-ID:	-	Length:	421	Species:	Danio rerio

Alignment Length:	436	Identity:	89/436 - (20%)
Similarity:	162/436 - (37%)	Gaps:	80/436 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLIIGQLWLSIGLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTFYW------ARWTCCPTLFEN 64
            |.|.|.|.|....::..:|:...:|..:.|.|.::  |.:...|.:|      ..|.      :|
Zfish    19 LHIPGSLTLQSLSVACKESVCAVKGSQVTLVCSYS--YRNNFKTAFWFSQKQNINWR------KN 75

  Fly    65 VAIGDVQLNSNYRLDFRPSRGIY--DLQIKNTSYNRDNGRFECRIKAKGTGADVHQEFYNLTVLT 127
            ....|:.|:|:|....:.|...|  .|.|.:.. .||:|.::.....|.....:.....||||..
Zfish    76 NEPEDLTLDSDYSGRVKSSISYYTSTLTISDVR-ERDSGEYQLMFIMKDGDKHLASVSINLTVTD 139

  Fly   128 APHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYALKG---GSKNHYTN 189
            ........|       .::.:||.|.|...|.|  .::|.:...:...|::.|.   .:||.|::
Zfish   140 LKMRMTTNP-------RDQTVELACDSYCSSKD--WSYYWKNGNIKYNSFSPKTFVVPNKNVYSH 195

  Fly   190 ATLQIVPRRADDGAKYKCV----VWNRAMPEGH---MLETSV------------TLNVNYYPRVE 235
              |..|.:...:.:...||    .|:.:.....   ::.::|            |:|..::...:
Zfish   196 --LCSVDQNIKNPSSSVCVSKSGCWDVSYTSTRICAVINSTVDISCTYSHPSDYTINKTFWHYGQ 258

  Fly   236 VGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSADNG 300
            .|....|..|.....:::. |:.|..:..::.|.:|:|                  ::....|..
Zfish   259 TGGFRDLCEEHQFAGRVEF-VENKLRIKKLKISDSGEY------------------RFRIITDKT 304

  Fly   301 LGK-TGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVE-WLKEG--APDFRY 361
            .|| :|...::|.|....::   |:.|...|||.|::.|:.....|..:.. |.|.|  ..|...
Zfish   305 EGKYSGSPGVILTVTDTQVI---SRPHTVSEGEKVILSCSTKCTLSNKHTYIWYKNGRQVTDGFT 366

  Fly   362 TGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLV 407
            ....|.|.||..|....:.| :|..|.|..:..::   |:.:.|.|
Zfish   367 KYNKLYLDSVSNEELQEFSC-AVREMSPEVNTALQ---NTLIVLFV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	23/104 (22%)
		IG_like	141..228	CDD:214653	19/108 (18%)
		Ig	147..228	CDD:299845	19/102 (19%)
		I-set	232..313	CDD:254352	13/81 (16%)
		IGc2	250..302	CDD:197706	6/51 (12%)
		IG_like	323..385	CDD:214653	18/64 (28%)
		IGc2	330..385	CDD:197706	16/57 (28%)
		Ig_2	416..501	CDD:290606
		IG_like	418..501	CDD:214653
		I-set	505..612	CDD:254352
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
LOC100536326	XP_021325377.1	IG_like	36..137	CDD:214653	23/109 (21%)
LOC100536326	XP_021325377.1	Ig	222..319	CDD:325142	16/115 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010