DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fred and Kirrel2

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:XP_038957463.1 Gene:Kirrel2 / 100359836 RGDID:1308456 Length:711 Species:Rattus norvegicus


Alignment Length:655 Identity:152/655 - (23%)
Similarity:233/655 - (35%) Gaps:171/655 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 RWTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGAD 115
            :||     .:.:|:|   |:...|.|.:....:.|.:||.||.... .|...:||:....|..:.
  Rat    63 QWT-----KDGLALGGERDLPGWSRYWISGNSASGQHDLHIKPVEL-EDEASYECQASQAGLRSR 121

  Fly   116 VHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGS-PDPMITWYREGSTVPLQSY-- 177
            ..|    |.|:..|..|.|..|.........|..|||.|.|.: |.|.:.|:|:|..:...|:  
  Rat   122 PAQ----LHV
MVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDARPAPELLWFRDGIRLDGTSFHQ 182

  Fly   178 -ALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNP 241
             .|:..:.....| ||.:.|...||||...|...::|:|.|.  :|:|||::.|.|.|.:..:..
  Rat   183 ITLRDKATGTVEN-TLFLTPSSQDDGATLICRARSQALPTGR--DTAVTLSL
QYPPMVTLSAEPQ 244

  Fly   242 LKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYV--SATPTHTIYRVNRHHAGKYTCSADNGLGKT 304
            ...|.:.|..| |:..|:|.|:..||::.|..|  :..|...:...........:|...|.:| :
  Rat   245 TAQEGEKVTFL-CQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVG-S 307

  Fly   305 GEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLG 369
            ..:...|:|||.||:..:.|....:.|:.....|....||.| .:.|.:.|......:|..|.|.
  Rat   308 ANRSTALEVLYGPILQAKPKPVSVDVGKDASFSCVWRGNPLP-RISWTRLGGSQVLSSGPTLRLP 371

  Fly   370 SVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCS 434
            ||..|.||:|:||:    :|    |..|||..|         .||.:|.|.|.|       :|..
  Rat   372 SVALEDAGDYVCRA----EP----RRTGVGGGT---------AQARLTVNAPPV-------VTAL 412

  Fly   435 ANPPGW--------------PVP-QYRWFRDMDG--DIGNTQKIL-----------AQGPQYSIP 471
            ...|.:              |.| ...|..| :|  :.|:..:.|           .|||.. |.
  Rat   413 HPAPAFLRGPARLQCVVFASPAPDSVVWSWD-EGFLEAGSLGRFLVEAFPAPEVEGGQGPGL-IS 475

  Fly   472 KAHLGSEGK------YHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSA 530
            ..|:....:      ::|.|.|.||.|::                 |.|:.||            
  Rat   476 VLHISGTQESDFTTGFNCSARNRLGEGRV-----------------QIHLGRR------------ 511

  Fly   531 KGKPTPQIRWIKDGTEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLY 595
                           ::|||.::         ..|...|..|:...              ..|:.
  Rat   512 ---------------DLLPTVRL---------VAGAASAATSLFMV--------------ITGVV 538

  Fly   596 TCLYENDV------------NSANSSMHLRIEHE-------PIVIHQYNKVAYDLRESAEVVCRV 641
            .|.:.:..            :|..||.|...|..       |||...:|.:..:..|:.|.....
  Rat   539 LCCWRHGSLSKQKNLVRIPGSSEGSSAHGPEEETGSSEDRGPIVHTDHNDLVLEENEALETKDPT 603

  Fly   642 QAYPK 646
            ..|.|
  Rat   604 NGYYK 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 18/74 (24%)
IG_like 141..228 CDD:214653 29/90 (32%)
Ig 147..228 CDD:299845 29/84 (35%)
I-set 232..313 CDD:254352 18/82 (22%)
IGc2 250..302 CDD:197706 12/53 (23%)
IG_like 323..385 CDD:214653 19/61 (31%)
IGc2 330..385 CDD:197706 18/54 (33%)
Ig_2 416..501 CDD:290606 24/118 (20%)
IG_like 418..501 CDD:214653 23/116 (20%)
I-set 505..612 CDD:254352 15/118 (13%)
Ig 526..611 CDD:143165 11/96 (11%)
IG_like 633..715 CDD:214653 4/14 (29%)
Ig 635..713 CDD:143165 3/12 (25%)
FN3 720..838 CDD:238020
Kirrel2XP_038957463.1 IG_like 38..127 CDD:214653 18/73 (25%)
Ig strand A' 40..44 CDD:409353
Ig strand B 48..57 CDD:409353
Ig strand C 62..66 CDD:409353 2/7 (29%)
Ig strand D 75..85 CDD:409353 3/9 (33%)
Ig strand E 88..100 CDD:409353 4/11 (36%)
Ig strand F 107..115 CDD:409353 2/7 (29%)
Ig strand G 117..127 CDD:409353 3/13 (23%)
Ig 133..231 CDD:416386 32/100 (32%)
Ig strand A 134..137 CDD:409353 1/2 (50%)
Ig strand A' 140..144 CDD:409353 0/3 (0%)
Ig strand B 151..158 CDD:409353 4/6 (67%)
Ig strand C 164..169 CDD:409353 1/4 (25%)
Ig strand C' 172..174 CDD:409353 1/1 (100%)
Ig strand D 177..184 CDD:409353 1/6 (17%)
Ig strand E 191..199 CDD:409353 3/8 (38%)
Ig strand F 208..216 CDD:409353 2/7 (29%)
Ig strand G 222..228 CDD:409353 2/7 (29%)
Ig_3 234..303 CDD:404760 15/69 (22%)
Ig strand B 252..256 CDD:409353 2/4 (50%)
Ig strand C 266..270 CDD:409353 1/3 (33%)
Ig strand E 283..286 CDD:409353 0/2 (0%)
Ig strand F 292..301 CDD:409353 1/8 (13%)
Ig strand G 309..312 CDD:409353 0/2 (0%)
Ig 326..403 CDD:416386 27/94 (29%)
Ig strand A' 327..332 CDD:409353 1/4 (25%)
Ig strand B 335..344 CDD:409353 1/8 (13%)
Ig strand C 350..354 CDD:409353 0/3 (0%)
Ig strand C' 357..359 CDD:409353 1/1 (100%)
Ig strand D 362..365 CDD:409353 0/2 (0%)
Ig strand E 366..371 CDD:409353 1/4 (25%)
Ig strand F 379..387 CDD:409353 4/11 (36%)
Ig strand G 393..403 CDD:409353 4/18 (22%)
Ig 405..509 CDD:416386 24/129 (19%)
Ig strand A 406..410 CDD:409353 2/10 (20%)
Ig strand A' 412..415 CDD:409353 0/2 (0%)
Ig strand B 423..430 CDD:409353 0/6 (0%)
Ig strand C 437..442 CDD:409353 1/4 (25%)
Ig strand C' 444..447 CDD:409353 1/2 (50%)
Ig strand D 455..462 CDD:409353 1/6 (17%)
Ig strand E 472..479 CDD:409353 1/7 (14%)
Ig strand F 490..497 CDD:409353 2/6 (33%)
Ig strand G 500..507 CDD:409353 3/23 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342413
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.