DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and kirrel2

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	NP_001135598.1	Gene:	kirrel2 / 100216155	XenbaseID:	XB-GENE-854070	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	854	Identity:	197/854 - (23%)
Similarity:	302/854 - (35%)	Gaps:	218/854 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTIKLLIIGQLWLSIGLISG-----------DDSLDTREGVDLVLKCRFTEHYDSTDFTFYWAR 54
            |..:.||    ||:.:||:.|           .|.:.. .|..:.|.|....:...       .:
Frog     1 MKNLWLL----LWIHVGLLLGKSFGAHFSQQPSDKVIV-AGKSVTLPCVVIGYRGV-------VQ 53

  Fly    55 WTCCPTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADV 116
            ||     .:.:|:|   |:...|.|.:...||.|.::|.|:....: |:..:||    :.|.|.:
Frog    54 WT-----MDGLALGAERDLPGWSRYSVVGDPSLGEHNLHIEGVELS-DDAIYEC----QATQAAL 108

  Fly   117 HQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTVPLQSYA--L 179
            ..:...||||..|..||:....:|......|..|||.:....|...|||||:|..:....|.  |
Frog   109 RSQRARLTVLLPPGDPMIPGSPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKKLDSAVYTKEL 173

  Fly   180 KGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRVEVGPQNPLKV 244
            ....|:..:.::|.|.|..||.|:.|.|.|.|.|:|||.  |.||||:|.|.|:|.:..:.|...
Frog   174 LSDGKSEGSASSLLITPSLADSGSSYTCRVRNEALPEGR--EKSVTLSVQYPPKVTLSVEPPTIT 236

  Fly   245 ERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHH---AGKYTCSADNGLGKTGE 306
            |...|..| |...:.|.|:..||::.|  |....:...|.|...|   ....:|...|.:|.:..
Frog   237 EGGSVTFL-CGAVSNPEVTGYRWAKGG--VPLAVSGDKYTVEVDHTFFTAPVSCEVSNSVGASNV 298

  Fly   307 KDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSV 371
            ...| :||:.|.:..|.:....:.|:.....|..|.||:|... |.|:|..:....|..|.|..|
Frog   299 STAV-NVLFGPRLLTEPRPMTVDIGDDASFFCGWTGNPTPTQF-WSKKGTGEVLSNGNTLLLTKV 361

  Fly   372 RAEHAGNYICRSVNIMQPFSSKRVEGVGNS--TVALLVRHRPGQAYITPNKPVVH----VGNGVT 430
            ..|.||.|:|:::          |..:|::  .|.|.||   |...||..   :|    :|....
Frog   362 TREDAGIYVCKAI----------VPRMGSTEKEVTLTVR---GPPIITSE---MHYETTLGGKAR 410

  Fly   431 LTCSANPPGWPVPQ---YRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHA-VNELGI 491
            :.|...  ..|.|.   :.|.:....|                     ||.|::.... |.|  :
Frog   411 MECLIE--STPAPDRIVWAWDKQSLED---------------------GSWGRFSVETEVTE--V 450

  Fly   492 GKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQIRWIKDGTEILPTRKMFDI 556
            |.|:.::::..:...||.:.               .|||       |....:.:.|:..|:...:
Frog   451 GAISVLVIDGAEQSDFLTEF---------------NCSA-------INQYGEDSVIVSLRQQAAL 493

  Fly   557 RTT--PTDAGGG-----VVAVQSILRFRGKARP----NGNQLLPNDRGLYTCLYENDVNSANSSM 610
            ..|  ....|.|     |:.:.|||..|   ||    ...|:|..|..          .|..|..
Frog   494 PLTLLLIAVGSGTLCIFVLVITSILCCR---RPKKAVKDTQILAVDVS----------GSEPSER 545

  Fly   611 HLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMSSDGHYEISTRME 675
            |.....|            ||:|........|.    ..|.::.:.|......::|:|::  |..
Frog   546 HPSDSEE------------DLKEPLHTDTESQR----TSQTEHSDIPDEPQDPTNGYYKV--RAH 592

  Fly   676 NNDVYTSILRIAHLQHSDYGEYIC--RAVNPLDSIRAPIRLQPKGSPEKPTNLKILEVGHNYAVL 738
            .:...|:|         .|.|:..  |.:....|..:|:...|.|.|      ||.:..|.||
Frog   593 EDTRPTTI---------TYPEFSSPPRPLYSTTSSLSPLCPTPSGPP------KIYDYAHRYA-- 640

  Fly   739 NWTPGFNGGFMSTKYLVSYRRVATPREQTLSDCSGNGYIPSYQISSSSSNSNHEWIEFNCFKENP 803
                                  .|||       ||..::|....|.....:.|       ..:.|
Frog   641 ----------------------TTPR-------SGGHHMPQGSSSHLPQGTTH-------LPQGP 669

  Fly   804 CKLAPLDQH 812
            ..|..:..|
Frog   670 MHLPQVPTH 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	22/99 (22%)
		IG_like	141..228	CDD:214653	33/88 (38%)
		Ig	147..228	CDD:299845	33/82 (40%)
		I-set	232..313	CDD:254352	20/83 (24%)
		IGc2	250..302	CDD:197706	13/54 (24%)
		IG_like	323..385	CDD:214653	18/61 (30%)
		IGc2	330..385	CDD:197706	18/54 (33%)
		Ig_2	416..501	CDD:290606	16/92 (17%)
		IG_like	418..501	CDD:214653	14/90 (16%)
		I-set	505..612	CDD:254352	23/117 (20%)
		Ig	526..611	CDD:143165	21/95 (22%)
		IG_like	633..715	CDD:214653	14/83 (17%)
		Ig	635..713	CDD:143165	13/79 (16%)
		FN3	720..838	CDD:238020	17/93 (18%)
kirrel2	NP_001135598.1	IG_like	28..117	CDD:214653	22/106 (21%)
		Ig2_KIRREL3-like	139..220	CDD:143236	33/82 (40%)
		Ig_2	225..294	CDD:372793	17/71 (24%)
		Ig	308..389	CDD:386229	24/91 (26%)
		Ig	391..488	CDD:386229	24/146 (16%)
		Atrophin-1	529..>765	CDD:367360	42/231 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11157
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000