DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fred and kirrel1b

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	874	Identity:	192/874 - (21%)
Similarity:	317/874 - (36%)	Gaps:	244/874 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LWL-SIGLIS--------------GDDSLDTREGVDLVLKCRFTEHYDSTDFTFYW---ARWTCC 58
            ||: ::.:||              .|.|:...|.|  ||.|          ..|.:   .:||
Zfish     8 LWIVTLAIISVHRVFSGPRFSQEPADQSVVIGERV--VLSC----------VVFNYTGIVQWT-- 58

  Fly    59 PTLFENVAIG---DVQLNSNYRLDFRPSRGIYDLQIKNTSYNRDNGRFECRIKAKGTGADVHQEF 120
               .:.:|:|   |::....||:......|.|:|:|.:.... |:..:||    :.|.|.:....
Zfish    59 ---KDGLALGIGEDLRAWPRYRVLRIMDVGQYNLEITSADLT-DDSLYEC----QATEAALRSRR 115

  Fly   121 YNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREGSTV--PLQSYALKGGS 183
            ..||||..|..|::......:.|......|||.|.|..|...|.||::|..|  ...|..:....
Zfish   116 AKLTVLIPPDGPVIEGSPEILLTAGTSFNLTCVSRGAKPMSTIEWYKDGIIVEGAHTSTEVLSDR 180

  Fly   184 KNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETSVTLNVNYYPRV--EVGPQNPLKVER 246
            |...|.:.|:|.|...|.|..:.||..|.|.|.|.  .::||||:::.|.|  .:.|::.|:.||
Zfish   181 KRVTTKSFLEIQPMDTDTGRNFTCVASNLAAPLGK--RSTVTLNIHHPPTVILSIEPRSVLEGER 243

  Fly   247 DHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHA---GKYTCSADNGLGKTGEKD 308
               .|..|:..|.|.:...||::.|..:... ..:::.....|:   ...:|...|.:|.| ...
Zfish   244 ---VKFTCQATANPPIMGYRWAKGGVILDGA-RESVFETTADHSFFTEPVSCLVFNAVGST-NVS 303

  Fly   309 IVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRA 373
            |::||.:.||:.:|.:....:....|.:.|..:.|| |:.:.|.|:|:.........|.|.||..
Zfish   304 ILVDVHFGPILVVEPRPVTVDVDSDVTLNCKWSGNP-PLTLTWTKKGSSMVLSNSNQLFLKSVSQ 367

  Fly   374 EHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHV--GNGVTLTC--- 433
            ..||.|:|:::       ..|: |||.:.|.|.|...|    |..::|:.:.  |....:.|
Zfish   368 ADAGQYVCKAI-------VPRI-GVGETEVTLTVNGPP----IISSEPIQYAVRGEKGEIKCYIA 420

  Fly   434 SANPPG---WPVPQYRWFRDMDGDIGNTQKILAQG---PQYSIPKAHLGSEG------------- 479
            |..||.   |...:..|.::             :|   .:|::.::...::|
Zfish   421 STPPPDKIVWAWKENVWEKE-------------RGTLLERYTVEQSRPATQGGAVLSTLTINNVM 472

  Fly   480 ------KYHCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSAKGKPTPQI 538
                  .|:|.|.|..|.|   |:|:.:.                  :.|.|
Zfish   473 EADFQSTYNCTAWNAFGPG---TMIITLE------------------ETDIA------------- 503

  Fly   539 RWIKDGTEILPTRKMFDIRTTPTDAGGGV----------VAVQSILRFRGKARPNGNQLLPNDRG 593
                 ..:|:|...:         |||.|          .|:...|..:.|:...|..|.| |..
Zfish   504 -----SEDIVPVGVI---------AGGSVGSSILLLLLLFALIFYLYRQRKSSRRGVTLKP-DIK 553

  Fly   594 LYTCLYENDV--NSANSSMHLRIEHEPIVIHQYNKVAYDLRESAEVVCRVQAYP----------- 645
            :.|...|.::  .:|::|...|:.          |..|....|..:....|.:.
Zfish   554 VETVNKETNLEEEAASASTATRMV----------KAMYSFLPSVSLSPSTQPFKDDMDLKQDLQT 608

  Fly   646 ---KPEFQWQYGNNPSPLTMSSDGHYEI--STRMENNDVYTSILRIAHLQHSDYGEYICRAVNPL 705
               :|:.:.....:|      ::|:|.:  :|..|......|:|         |.|:  ||.||.
Zfish   609 ETLEPKVEEYEAKDP------TNGYYNVRATTHDEVRSSTRSLL---------YQEF--RAPNPA 656

  Fly   706 D---SIRAPIRLQ--PKGSPE-KPTNLKILEVGHN-YAVLNW-------TPGFNGGFMSTKYLVS 756
            .   |...|..:.  |.|..| :||:    .:.|| ||..|.       .|..|....:|.|
Zfish   657 SVSASTGGPANIHPAPTGRYEARPTS----RMAHNTYAHFNTIARASQIQPPANPVSKTTDY--- 714

  Fly   757 YRRVATPREQTLSDCSGNGYIPSYQISSS 785
                  |.|:.|.:.:......||..|::
Zfish   715 ------PAERGLLESTNPLAFDSYAYSTT 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	24/102 (24%)
		IG_like	141..228	CDD:214653	29/88 (33%)
		Ig	147..228	CDD:299845	28/82 (34%)
		I-set	232..313	CDD:254352	19/85 (22%)
		IGc2	250..302	CDD:197706	10/54 (19%)
		IG_like	323..385	CDD:214653	16/61 (26%)
		IGc2	330..385	CDD:197706	16/54 (30%)
		Ig_2	416..501	CDD:290606	20/114 (18%)
		IG_like	418..501	CDD:214653	19/112 (17%)
		I-set	505..612	CDD:254352	19/118 (16%)
		Ig	526..611	CDD:143165	17/96 (18%)
		IG_like	633..715	CDD:214653	18/100 (18%)
		Ig	635..713	CDD:143165	17/96 (18%)
		FN3	720..838	CDD:238020	18/75 (24%)
kirrel1b	XP_017212964.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840