DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and LOC100149229

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_021333810.1	Gene:	LOC100149229 / 100149229	-ID:	-	Length:	335	Species:	Danio rerio

Alignment Length:	379	Identity:	82/379 - (21%)
Similarity:	136/379 - (35%)	Gaps:	113/379 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MITWYREGSTVPLQSYALKGGSKNHYTNATLQIVPR--RADDGAKYK----CVVWNRAM------ 214
            |:.|.|....:.|               ..|.|:.|  .|:...||.    |.:.|..|
Zfish     1 MLMWLRMAPALHL---------------IFLLIIHRVSAAEWSTKYNATEICALQNSTMTISCTF 50

  Fly   215 --PEGHMLETSVTLNVNYYPRVEV---GPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYV 274
              |||..:..:      ::.:.||   |....|..:.::..:|....| |.....||.|    :|
Zfish    51 THPEGLQIMRA------FWNKNEVKHDGELTDLSEDPEYSQRLQYLGD-KQHNRTVRLS----HV 104

  Fly   275 SATPTHTIY-RVNRHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLI-- 336
            :....|..| |:..:      .||...|||.|.:..|.|:.      :|| .....||::|.:
Zfish   105 TKKDEHEYYFRITTN------VSAQKWLGKPGVRLSVTDLQ------LES-PERVTEGDSVRLTC 156

  Fly   337 --RCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNY------------------IC 381
              .|.:|..|:.|   |.: .:......|:.|.:.||....||:|                  .|
Zfish   157 KSSCKLTDTPTFI---WYR-NSHTLTNIGDELNIRSVSRTEAGHYSCGVQGQMYISPAVYLDVTC 217

  Fly   382 RSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKPVVHV--------GNGVTLTC--SAN 436
            :.:::: |||....:     |..|.:..:..:....|:.||:.:        |:.|||.|  .:|
Zfish   218 KFLSVL-PFSVYLFK-----TYRLTINMKAVELKNAPDTPVIFLSGSAIIKEGDSVTLMCISHSN 276

  Fly   437 PPGWPVPQYRWFRDMDGDIGNTQKILAQGPQYSIPKAHLGSEGKYHCHAVNELG 490
            ||..   .:.||.:      |....:..|..:|..::     |:::|.|.|..|
Zfish   277 PPAL---NFSWFEE------NQSSAVGSGQSFSAVQS-----GRFYCEAHNPHG 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653	16/79 (20%)
		Ig	147..228	CDD:299845	16/79 (20%)
		I-set	232..313	CDD:254352	21/84 (25%)
		IGc2	250..302	CDD:197706	12/52 (23%)
		IG_like	323..385	CDD:214653	17/83 (20%)
		IGc2	330..385	CDD:197706	16/76 (21%)
		Ig_2	416..501	CDD:290606	21/85 (25%)
		IG_like	418..501	CDD:214653	21/83 (25%)
		I-set	505..612	CDD:254352
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
LOC100149229	XP_021333810.1	Ig	40..136	CDD:325142	25/112 (22%)
		Ig_3	142..199	CDD:316449	16/61 (26%)
		Ig_2	251..326	CDD:316418	20/80 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920