DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and LOC100148735

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_001919202.4	Gene:	LOC100148735 / 100148735	-ID:	-	Length:	440	Species:	Danio rerio

Alignment Length:	411	Identity:	95/411 - (23%)
Similarity:	158/411 - (38%)	Gaps:	78/411 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKLLIIGQL----WLSIGLISGDDSLDTREGVDLVLKCRFTEHYDSTDFTF---YWARWTCCPTL 61
            |.||||.::    |   |:......:...:...:.:.|.||  |.:|::..   :|.:    ..:
Zfish    14 IFLLIIHRVSAAGW---GVNYSPSHICALQNSTMTISCTFT--YPNTEYQIMKVFWNK----DQV 69

  Fly    62 FENVAIGDVQLNSNY--RLDFRPSRGIYDLQIKNTSYNRDNGRFECRIK-AKGTGADVHQEFYNL 123
            :..|...|:..:..|  ||.:...:                 :..|.|: :..|..|..|.::..
Zfish    70 YNGVEFADLSEDPEYSQRLQYLGDK-----------------QQNCTIRLSHVTKKDEGQYYFRF 117

  Fly   124 TVLTAPHPPMVTPGNLAVATE---EKP--------LELTC-SSIGGSPDPMITWYREGSTVPLQS 176
            |...|.......||.:...||   |.|        :.||| ||...:..|...|||...|:
Zfish   118 TTNVANQKWTGIPGVILSVTELQLESPERVKEGDSVRLTCRSSCKLTDTPTFIWYRNSHTL---- 178

  Fly   177 YALKGGSKNHYTNA--TLQIVPRRADDGAKYKCVVWNRAMPEGHMLET-SVTLNVNYYPR-VEVG 237
                       ||.  .|.|.|....|..:|:|.|      .||.|.: .|.|||.|.|: :.|.
Zfish   179 -----------TNIGDELNISPVSRGDAGRYRCAV------HGHTLTSPEVYLNVMYPPKSISVS 226

  Fly   238 PQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAGKYTCSADNGLG 302
            ......:.......|.|..|:.| .:.:.|.:....|.:.....|.:::...:|:|.|.|.|..|
Zfish   227 ISGSAVIMSGDSVTLSCSSDSNP-PAEINWYKGKTSVRSGRILNISKISSDDSGEYKCRARNAHG 290

  Fly   303 KTGEKDIVLDVLYPPIVFIESKTHEAE--EGETVLIRCNVTANPSPINVEWLKEGAPDFRYTGEL 365
            :.....:.|||.|||.....|.:..|.  .|::|.:.|:..:||..:|..|.|  ......:|.:
Zfish   291 EKYSDPVTLDVQYPPRSVSVSISGSAVIISGDSVTLSCSSDSNPPALNFSWFK--GETLVGSGRI 353

  Fly   366 LTLGSVRAEHAGNYICRSVNI 386
            .::.::.::.:|.|.||:.|:
Zfish   354 FSISNISSDDSGEYKCRAGNV 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845	17/102 (17%)
		IG_like	141..228	CDD:214653	28/101 (28%)
		Ig	147..228	CDD:299845	25/92 (27%)
		I-set	232..313	CDD:254352	16/81 (20%)
		IGc2	250..302	CDD:197706	12/51 (24%)
		IG_like	323..385	CDD:214653	15/63 (24%)
		IGc2	330..385	CDD:197706	13/54 (24%)
		Ig_2	416..501	CDD:290606
		IG_like	418..501	CDD:214653
		I-set	505..612	CDD:254352
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
LOC100148735	XP_001919202.4	Ig	27..127	CDD:299845	20/125 (16%)
		IG_like	143..216	CDD:214653	25/93 (27%)
		IGc2	149..205	CDD:197706	19/76 (25%)
		IG_like	228..301	CDD:214653	14/73 (19%)
		Ig_2	232..301	CDD:290606	14/69 (20%)
		IG_like	305..387	CDD:214653	17/72 (24%)
		Ig_2	321..387	CDD:290606	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920