DRSC/TRiP Functional Genomics Resources

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Protein Alignment fred and cd22

DIOPT Version :9

Sequence 1:NP_608812.3 Gene:fred / 33613 FlyBaseID:FBgn0051774 Length:1447 Species:Drosophila melanogaster
Sequence 2:XP_017945135.2 Gene:cd22 / 100135351 XenbaseID:XB-GENE-5887760 Length:858 Species:Xenopus tropicalis


Alignment Length:933 Identity:194/933 - (20%)
Similarity:344/933 - (36%) Gaps:239/933 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IKLLIIGQLWLSIGL---ISGDDSLDTRE------GVDLVLKCRFTEHYDSTDFTFY-------- 51
            ||:||:..:.|:.|.   :..||.::..|      |..:::.|...::....:|.:|        
 Frog    11 IKVLILVLMVLNAGFCYSVRTDDHVNFPEQISAWTGSCVLIPCYEKDNRRINNFLWYQNPEYDDD 75

  Fly    52 ---WARWTCCPTLFENVAIGDVQLNSNYRLDFRP----SRGIYDLQIKNTSYNRDNGRFECRIKA 109
               |.|    ..:::|.  ...:::|::....:|    ..|...:.:.|.. ..|:|.:..| ..
 Frog    76 KKQWTR----TVVYDNK--NTKKVDSHFEGRVKPYVGQGNGACGIVLHNVQ-EGDSGYYRLR-TI 132

  Fly   110 KGTGADVHQEFYNLTVLTAPHPPMVTPGNLAVATEEKPLELTCSSIGGSPDPMITWYREG----- 169
            .|....:.::..:|||..:....|:.|  :.|..|.:.|.|:|......||..|....:|     
 Frog   133 DGNDQWMTKKNVSLTVSDSGPELMIRP--VGVGREYQKLTLSCYVHYYCPDYDIKLSWDGDVRGE 195

  Fly   170 --STVPLQSYALKGGSKNHYTNATLQIVPRRADDGAKYKCVVWNRAMPEGHMLETS---VTLNVN 229
              :|||...:::: ..|...|.|.....|...|.....:|     |:.:|....|.   |.||:.
 Frog   196 TKTTVPRLEWSVR-NKKPIMTEAEFTFTPTWEDHNKTIQC-----ALTKGDSEVTKTGPVVLNIQ 254

  Fly   230 YYPR-VEVGPQ-NPLKVERDHVAKLDCRVD-AKPMVSNVRWSRNGQYVSATPTHTIYRVNRHHAG 291
            |.|: |.:.|: :|:.:.:.....|:|..: :.|.:...||.::...:..:.:|    .:...:|
 Frog   255 YSPKGVRIRPETSPVTISKGEEVALECTAESSNPPIDTYRWYKSANNIVGSNSH----YSARESG 315

  Fly   292 KYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLIRCNVTANPSPINVEWLKEGA 356
            .|.|.|:|.:|:|..|.:.::|||.|.|.::..:.|..||....:.|:|.|||..:|:.|.|:..
 Frog   316 TYYCEAENTIGRTRSKGVAINVLYAPTVTLKIPSREIREGSQYTLTCSVDANPQLVNITWYKDYE 380

  Fly   357 PDFRYTGELLTLGSVRAEHAGNYICRSVNIMQPFSSKRVEGVGNSTVALLVRHRPGQAYITPNKP 421
            .......:.||...:|.:.:|:|.|.:.||:...||..|      .|.::...:..:..:.|.||
 Frog   381 KILNKNRDTLTFPYIREQESGSYHCEAQNIIGSESSADV------YVDVVYAPKNPEVVVEPKKP 439

  Fly   422 VVHVGNGVTLTCSANPPGWPVPQYRWFRDMDGDIGNTQKILA-QGPQY----SIPKAHLGSEGKY 481
            ....|:.:..:|:.|.....|.|..|:::        :|::| :...|    :|.:.|   .|.|
 Frog   440 SFVEGSSLRFSCNVNSSNPGVSQITWYKN--------EKVMASERKNYIIIDTIKEEH---HGNY 493

  Fly   482 HCHAVNELGIGKIATIILEVHQPPQFLAKLQQHMTRRVGDVDYAVTCSA-KGKPT-PQIRWIKDG 544
            .|.|.|::|......:.:.|..||:.:....|......|| ...:.||. |..|| .:.||.|| 
 Frog   494 MCKAGNKIGATSSQAVSINVLYPPKGVRVTPQAQIITEGD-RIRLACSVDKSNPTVTEFRWYKD- 556

  Fly   545 TEILPTRKMFDIRTTPTDAGGGVVAVQSILRFRGKARPNGNQLLPNDRGLYTCLYENDVNSANSS 609
            :.:.|.|                   ...:.|.|..|        .|.|.|||...|.:.:..|.
 Frog   557 SALQPHR-------------------NKEITFPGIKR--------TDSGKYTCEARNGIGNVTSQ 594

  Fly   610 -MHLRIEHEPI----------VIHQYNKVAYDLRESAEVVCRVQAYPKPEFQWQYGNNPSPLTMS 663
             :.|.:::.|:          ::.::.||.        :.|..||||          |.....:.
 Frog   595 PITLNVQYAPVGVMVSSIPSNLVTEHTKVT--------LTCTAQAYP----------NTISYAIY 641

  Fly   664 SDGHYEISTRMENNDVYTSILRIAHLQHSDYGEYICRAVNPL----------------------- 705
            .||   :..:      |:..|.:.::|.||.|||.|.|.|.:                       
 Frog   642 KDG---VLLK------YSQSLVLDYIQLSDGGEYYCMATNSIGSGTSRTIDIHVSYGLTSIGKYI 697

  Fly   706 ------------------------------DSIRAPIRLQPKGSPEKPTNL--KILEVGH----- 733
                                          |...:...:..|..||.|.|.  :...||.     
 Frog   698 GIAVGIFTLLVLLIVAIHFKIWKMVFRFKADDSESHFIVMKKTHPELPDNAARQSPPVGSHLDQL 762

  Fly   734 NYAVLNWTPGFNGGFMS----------------TKYLVSYRRVATPREQ---------TLSDCSG 773
            ||:::.:.|...||..|                |.....|....:..::         |:::...
 Frog   763 NYSIIQFPPQPEGGAASRTNPNDQGVIYSVLQKTSKAHEYENTTSGTQEENSDEIHYSTIANLPR 827

  Fly   774 NGYIPS------YQISSSSSNSN 790
            .|.:||      |.:.|:..|.|
 Frog   828 GGMVPSRTSEVEYAMLSTQQNIN 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fredNP_608812.3 Ig 29..126 CDD:299845 18/117 (15%)
IG_like 141..228 CDD:214653 23/96 (24%)
Ig 147..228 CDD:299845 21/90 (23%)
I-set 232..313 CDD:254352 18/83 (22%)
IGc2 250..302 CDD:197706 11/52 (21%)
IG_like 323..385 CDD:214653 17/61 (28%)
IGc2 330..385 CDD:197706 16/54 (30%)
Ig_2 416..501 CDD:290606 20/89 (22%)
IG_like 418..501 CDD:214653 20/87 (23%)
I-set 505..612 CDD:254352 25/109 (23%)
Ig 526..611 CDD:143165 21/87 (24%)
IG_like 633..715 CDD:214653 20/134 (15%)
Ig 635..713 CDD:143165 20/130 (15%)
FN3 720..838 CDD:238020 22/109 (20%)
cd22XP_017945135.2 Ig 35..149 CDD:416386 18/121 (15%)
FR1 35..55 CDD:409353 3/19 (16%)
Ig strand A' 40..44 CDD:409353 0/3 (0%)
Ig strand B 46..56 CDD:409353 2/9 (22%)
CDR1 56..62 CDD:409353 0/5 (0%)
Ig strand C 62..69 CDD:409353 2/6 (33%)
FR2 63..69 CDD:409353 2/5 (40%)
CDR2 70..99 CDD:409353 4/34 (12%)
Ig strand C1 71..74 CDD:409353 0/2 (0%)
Ig strand C2 77..81 CDD:409353 1/3 (33%)
Ig strand C' 85..88 CDD:409353 0/2 (0%)
FR3 100..133 CDD:409353 6/34 (18%)
Ig strand D 101..105 CDD:409353 1/3 (33%)
Ig strand E 110..118 CDD:409353 1/7 (14%)
Ig strand F 125..133 CDD:409353 2/8 (25%)
CDR3 134..136 CDD:409353 1/1 (100%)
FR4 137..149 CDD:409353 2/11 (18%)
Ig strand G 137..149 CDD:409353 2/11 (18%)
Ig 164..253 CDD:416386 22/94 (23%)
Ig strand B 168..176 CDD:409353 3/7 (43%)
Ig strand C 184..190 CDD:409353 1/5 (20%)
Ig strand C' 192..195 CDD:409353 0/2 (0%)
Ig strand D 200..206 CDD:409353 2/5 (40%)
Ig strand E 213..222 CDD:409353 2/8 (25%)
Ig strand F 230..238 CDD:409353 2/12 (17%)
Ig strand G 243..251 CDD:409353 2/7 (29%)
Ig 257..339 CDD:416386 19/85 (22%)
Ig strand A 257..265 CDD:409353 2/7 (29%)
Ig strand A' 269..273 CDD:409353 0/3 (0%)
Ig strand B 274..284 CDD:409353 2/9 (22%)
Ig strand C 291..297 CDD:409353 2/5 (40%)
Ig strand C' 299..302 CDD:409353 0/2 (0%)
Ig strand F 315..323 CDD:409353 4/7 (57%)
Ig strand G 326..339 CDD:409353 4/12 (33%)
Ig 341..425 CDD:416386 25/89 (28%)
Ig strand A 341..347 CDD:409353 2/5 (40%)
Ig strand A' 351..354 CDD:409353 1/2 (50%)
Ig strand B 355..365 CDD:409353 2/9 (22%)
Ig strand C 371..377 CDD:409353 2/5 (40%)
Ig strand C' 379..382 CDD:409353 0/2 (0%)
Ig strand E 388..394 CDD:409353 2/5 (40%)
Ig strand F 401..409 CDD:409353 3/7 (43%)
Ig strand G 412..425 CDD:409353 4/18 (22%)
Ig_3 430..499 CDD:404760 18/79 (23%)
Ig strand A 430..433 CDD:409353 0/2 (0%)
Ig strand A' 438..442 CDD:409353 2/3 (67%)
Ig strand B 445..454 CDD:409353 1/8 (13%)
Ig strand E 478..484 CDD:409353 1/5 (20%)
Ig strand F 491..499 CDD:409353 4/7 (57%)
Ig strand G 504..513 CDD:409353 0/8 (0%)
Ig 516..602 CDD:416386 27/114 (24%)
Ig strand A 516..523 CDD:409353 2/6 (33%)
Ig strand A' 527..531 CDD:409353 0/3 (0%)
Ig strand B 532..542 CDD:409353 4/10 (40%)
Ig strand C 549..555 CDD:409353 2/5 (40%)
Ig strand E 565..571 CDD:409353 1/5 (20%)
Ig strand F 578..586 CDD:409353 4/7 (57%)
Ig strand G 589..602 CDD:409353 2/12 (17%)
Ig_2 617..683 CDD:404734 21/92 (23%)
Ig strand B 623..627 CDD:409353 1/11 (9%)
Ig strand C 635..641 CDD:409353 0/5 (0%)
Ig strand E 651..655 CDD:409353 1/3 (33%)
Ig strand F 665..670 CDD:409353 3/4 (75%)
Ig strand G 679..682 CDD:409353 0/2 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D35531at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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