DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fred and LOC100006104

DIOPT Version :9

Sequence 1:	NP_608812.3	Gene:	fred / 33613	FlyBaseID:	FBgn0051774	Length:	1447	Species:	Drosophila melanogaster
Sequence 2:	XP_021333821.1	Gene:	LOC100006104 / 100006104	-ID:	-	Length:	306	Species:	Danio rerio

Alignment Length:	356	Identity:	83/356 - (23%)
Similarity:	133/356 - (37%)	Gaps:	96/356 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MITWYREGSTVPLQSYALKGGSKNHYTNATLQIVPR--RADDGAKYK----CVVWNRAMPEG--- 217
            |:.|.|....:.|               ..|.|:.|  .|..|.||.    |.:.|..:...
Zfish     1 MLMWLRMAPALHL---------------IFLLIIHRVSAASWGVKYSTLKICALQNSTITISCTF 50

  Fly   218 -------HMLETSVTLNVNYYPRVEVGPQNPLKVERDHVAKLDCRVDAKPMVSNVRWSRNGQYVS 275
                   .:::...|.:||.:|.:.|.|:...:::         .:..|..:..||.|    :|:
Zfish    51 TYPTTVHQIMKVFWTKDVNGFPDLSVDPEYSQRLQ---------YLGDKQQICTVRLS----HVT 102

  Fly   276 ATPTHTIY--RVNRHHAGKYTCSADNGLGKTGEKDIVLDVLYPPIVFIESKTHEAEEGETVLI-- 336
            ....|..|  .:...:.||:|       |..|.:..|.|:.      :|| .....||::|.:
Zfish   103 KKDEHQYYFRFITDQNGGKWT-------GTPGVRLSVTDLQ------LES-PERVTEGDSVRLTC 153

  Fly   337 --RCNVTANPSPINVEWLKEGAPDFRYTGELLTLGSVRAEHAGNYIC--RSVNIMQPFSSKRVEG 397
              .|.:|..|:.|   |.: .:......|:.|.:.||....||:|.|  :..|.:.|
Zfish   154 KSSCKLTDTPTFI---WYR-NSHTLTNIGDELNISSVSRTEAGHYSCGVQKYNYISP-------- 206

  Fly   398 VGNSTVALLVRHRPGQAYITPNKPVVHV-GNGVTLTCS--ANPPGWPVPQYRWFRDMDGDIGNTQ 459
                .|.|.||:.|....::.|:..|.| |:.|||.||  :|||..   .:.||::        .
Zfish   207 ----AVYLNVRYPPRNISVSMNRSAVIVEGDSVTLNCSSDSNPPAL---IFNWFKE--------N 256

  Fly   460 KILAQGPQYSIPKAHLGSEGKYHCHAVNELG 490
            |.|..|..::|.|......|:|.|.|.|:.|
Zfish   257 KSLNSGRIFNIFKISSDDSGEYKCRARNDHG 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fred	NP_608812.3	Ig	29..126	CDD:299845
		IG_like	141..228	CDD:214653	14/81 (17%)
		Ig	147..228	CDD:299845	14/81 (17%)
		I-set	232..313	CDD:254352	16/82 (20%)
		IGc2	250..302	CDD:197706	10/53 (19%)
		IG_like	323..385	CDD:214653	17/67 (25%)
		IGc2	330..385	CDD:197706	16/60 (27%)
		Ig_2	416..501	CDD:290606	25/78 (32%)
		IG_like	418..501	CDD:214653	25/76 (33%)
		I-set	505..612	CDD:254352
		Ig	526..611	CDD:143165
		IG_like	633..715	CDD:214653
		Ig	635..713	CDD:143165
		FN3	720..838	CDD:238020
LOC100006104	XP_021333821.1	Ig	36..113	CDD:325142	15/89 (17%)
		IGc2	145..196	CDD:197706	15/54 (28%)
		Ig_2	226..298	CDD:316418	24/73 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D35531at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010