DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and BNR1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_012107.1	Gene:	BNR1 / 854647	SGDID:	S000001421	Length:	1375	Species:	Saccharomyces cerevisiae

Alignment Length:	1547	Identity:	299/1547 - (19%)
Similarity:	510/1547 - (32%)	Gaps:	511/1547 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRGSRVRVLSRLMGQKRIREAFLHSPKLGSSSE---VNLQGAGNGSSDWIAAETEVEHGQLDCSA 104
            ||...:....|:...:::.|..|:...:.:..:   |.|:..|.||..::.        |.:.||
Yeast    14 RRSLSLHARDRVSEARKLEELNLNDGLVAAGLQLVGVALEKQGTGSHIYMK--------QKNFSA 70

  Fly   105 EPADFHDVVSLDCTDSLEYHNCSSDECCYASNDTLTER--------------------QNRELQQ 149
            .......:||.:...|    ....:..|...:.:|.||                    ||..|::
Yeast    71 NDVSSSPMVSEEVNGS----EMDFNPKCMPQDASLVERMFDELLKDGTFFWGAAYKNLQNISLRR 131

  Fly   150 RQRQHHHHHHHIHNAHESHHHYPYDRRSLCTSCSSNDSLFTDPVDELIISKHYLNTAAKEHNNPK 214
            :...       |.....|:|   :.::.:.:|.:.:..|.|   :||..:.|:|:..
Yeast   132 KWLL-------ICKIRSSNH---WGKKKVTSSTTYSTHLAT---NELAENAHFLDGL-------- 175

  Fly   215 AKRDRPLSEISVTSVDTLSPNTAKAVLELQKRCRADKLACLSLTRVTYLS---------IANDLQ 270
                       |.::.|.....:||:.:|:|..|......|.|....||:         |:.:||
Yeast   176 -----------VRNLSTGGMKLSKALYKLEKFLRKQSFLQLFLKDEIYLTTLIEKTLPLISKELQ 229

  Fly   271 EV---------EEP-DRASILHD-------TDLLVAPNSPAESSPDEELMALQLGKKLAQVLGSG 318
            .|         ..| .|...||.       |:||...||..:.    :|::::|...|..|.||
Yeast   230 FVYLRCFKILMNNPLARIRALHSEPLIRWFTELLTDQNSNLKC----QLLSMELLLLLTYVEGS- 289

  Fly   319 AGSPLTPGTM----------------EPCAAGSGSPLANGEL------------------FNVSK 349
            .|..|....:                :..|..|...|...:|                  ||...
Yeast   290 TGCELIWDQLSILFTDWLEWFDKILADDIAIHSSLYLNWNQLKIDYSTTFLLLINSILQGFNNKT 354

  Fly   350 A-------KKVELQNLSSRFTAAVTQTPPGVT-------------------SSTPNESGVTGPAG 388
            |       ||..:.|..:....|....|..|.                   ..|.|::....|..
Yeast   355 ALEILNFLKKNNIHNTITFLELAYKDDPNSVVIMEQIKQFKSKESAIFDSMIKTTNDTNSLHPTK 419

  Fly   389 PLGATTSSP-SLETQSTVIISFKSSQTPVQSQTNSAASE--NVEDDTAPLPLPPPPPGFGTPTTP 450
            .:....|.| .||.    .:..|:..:||::..|.....  .:.|...|.       ........
Yeast   420 DIARIESEPLCLEN----CLLLKAKDSPVEAPINEIIQSLWKILDSQKPY-------SESIKLLK 473

  Fly   451 LLSSNVLKKVASFTVEKSSAGNNSSNPPNLCPTSDETTLLATPCS-------SSLTVATLPPEIA 508
            |::|.:...:.||.|        |:|     |:.|||...|....       :.|..:....|||
Yeast   474 LINSLLFYLIDSFQV--------STN-----PSFDETLESAENVDYVFQDSVNKLLDSLQSDEIA 525

  Fly   509 VGAAAGGVAGGAGSRRG----------SSYVPEKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSG 563
                          ||.          .|::.|||:..  |..:...||..|
Yeast   526 --------------RRAVTEIDDLNAKISHLNEKLNLV--ENHDKDHLIAKL------------- 561

  Fly   564 DANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLTPGKLDKVA 628
            |.::.|.         :||    .|:|.|..|                    .|..|..:||::.
Yeast   562 DESESLI---------SLK----TKEIENLKL--------------------QLKATKKRLDQIT 593

  Fly   629 AWP--FSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLLNCTTLA 691
            ...  :...||    |.|::|:      :|||:.      ..:|......|.:.||:
Yeast   594 THQRLYDQPPS----LASSNLS------IAGSII------KNNSHGNIIFQNLAKKQ-------- 634

  Fly   692 EVHAVVNELLSSVDEPPRR----PSKRCVNLTELLNASEATVYEYNKTGAEGCVKSFTDA----E 748
                   :....:..|.|.    .|||..:|:..|                      |||    |
Yeast   635 -------QQQQKISLPKRSTSLLKSKRVTSLSSYL----------------------TDANNENE 670

  Fly   749 TQTESEDCEGTCKCGQSSTKVSDN---------------ESAKEDGEKPHAVAPPPPPPPPPLHA 798
            :|.||||........:|::.::.|               .|...:.|..:::...|.....|:.:
Yeast   671 SQNESEDKSKDSLFQRSTSTINFNIPSMKNITNMQNVSLNSILSELEFSNSLGTQPNYQSSPVLS 735

  Fly   799 FVAPPP---------------------------PPPPPPPPPPPLANYGAPPPPPPPPPGSGSAP 836
            .|:..|                           ||||||||||||...........|...|..|.
Yeast   736 SVSSSPKLFPRLSSDSLDNGIQLVPEVVKLPQLPPPPPPPPPPPLPQSLLTEAEAKPDGVSCIAA 800

  Fly   837 PPPPPAP----IEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPM 897
            |.|||.|    .:..|.:|||||            |.|||:         :.:|.|...|..
Yeast   801 PAPPPLPDLFKTKTCGAVPPPPP------------PPPLPE---------SLSMNKGPSNHD--- 841

  Fly   898 RPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETP 962
                   :||  ||||..|:...|:.|...:.::.|..|       |||.....:..|.::|:..
Yeast   842 -------LVT--PPAPPLPNGLLSSSSVSINPTTTDLKP-------PPTEKRLKQIHWDKVEDIK 890

  Fly   963 LDNIDEFTELFSRQA----------------IAPVSKPKELKVKR------------------AK 993
             |.:.|.|  |.||.                |..:..|.::..||                  .|
Yeast   891 -DTLWEDT--FQRQETIKELQTDGIFSQIEDIFKMKSPTKIANKRNAESSIALSSNNGKSSNELK 952

  Fly   994 SIKVLDPERSRNVGIIWRSLHVPS--SEIEHA--IYHIDTSVVSLEALQHMSNIQ-ATEDELQRI 1053
            .|..|..:.::..||   :||:.|  |::|..  :.:.|..:|     |:::.:: ..::||..|
Yeast   953 KISFLSRDLAQQFGI---NLHMFSQLSDMEFVMKVLNCDNDIV-----QNVNILKFFCKEELVNI 1009

  Fly  1054 KE---------AAGGD----IPLDHPEQFLLD--ISLISMASERISCIVFQAEFEESVTLLFRKL 1103
            .:         :.|.|    ..|...::..|:  |:|....:.|...::..:.:|.....|..||
Yeast  1010 PKSMLNKYEPYSQGKDGKAVSDLQRADRIFLELCINLRFYWNARSKSLLTLSTYERDYYDLIFKL 1074

  Fly  1104 ETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSK-ESHTTLL 1167
            :.:......|..|...|.:..||..:||:||     :....|..|..|.||..|:|. :.:.:.|
Yeast  1075 QKIDDAISHLNRSPKFKSLMFIITEIGNHMN-----KRIVKGIKLKSLTKLAFVRSSIDQNVSFL 1134

  Fly  1168 HFIVRTYIAQRRKEGVHPLEIRLP-----IPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTT 1227
            |||.:.            :.|:.|     :.:..::|...::..|.|:.:..:.:||..... |.
Yeast  1135 HFIEKV------------IRIKYPDIYGFVDDLKNIEDLGKISLEHVESECHEFHKKIEDLV-TQ 1186

  Fly  1228 AKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLE---TMRFYHFSPKACTLTL 1289
            .:|...|:.|.::|....:::.....:::..|....:.:|:...::   .|::|...||
Yeast  1187 FQVGKLSKEENLDPRDQIIKKVKFKINRAKTKSELLIGQCKLTLIDLNKLMKYYGEDPK------ 1245

  Fly  1290 AQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIESRRNVSTK 1341
            .:.:.::||:.:..|...||...|:.|.....|.:.:.:::.::.|.:.:.|
Yeast  1246 DKESKNEFFQPFIEFLAMFKKCAKENIEKEEMERVYEQRKSLLDMRTSSNKK 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	99/489 (20%)
BNR1	NP_012107.1	FH2	868..1265	CDD:396655	85/438 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810