DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and fmn2

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_002935863.3	Gene:	fmn2 / 779576	XenbaseID:	XB-GENE-5955925	Length:	1607	Species:	Xenopus tropicalis

Alignment Length:	1681	Identity:	398/1681 - (23%)
Similarity:	589/1681 - (35%)	Gaps:	558/1681 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CYASNDTLTERQNRELQQRQRQHHHHHHHIHNAHESHHHYPYDR---RSLCTSCS----SNDSLF 189
            |:.|  ::.::|.::|.|.|..    ...:.||..|..|.|..:   .||||..:    :..::.
Frog    29 CFPS--SILKQQQQQLYQEQPL----EGAVRNASLSTEHVPVVQPASSSLCTQAADGREAQQTIA 87

  Fly   190 TDPV-------------------------DELIISKHYLN---------------------TAAK 208
            :.|.                         |.|.|....|:                     ...|
Frog    88 SLPTKRKKRGFIASLASASATHLKHWNRNDLLAIKGRALSKMGNQDAKLKKCSGDVQEGAEAGPK 152

  Fly   209 EHNNPK--------AKRDRPLSEISVTSVDTLSPNTAKA----------VL--------ELQKRC 247
            :..|.|        .||.:..|..|:.|...:....:||          ||        ||...|
Frog   153 DGENTKKGGKKTLGKKRSKSESRSSMFSNLRIRKTLSKARDGACGSKEDVLGSQALHTEELDSAC 217

  Fly   248 -----------RADKLACLSLTRVTYLSIANDLQ------EVEEPDRASILHDTDLLVAPNSPAE 295
                       .||: |.||.|...:..|.:|:.      :.:|..|.|...|||:.   :..:.
Frog   218 SVLTKTPDISISADE-AGLSDTDADHFEIPHDVPVAAAKCDAQEGQRTSSGSDTDIY---SFHSA 278

  Fly   296 SSPDEELMALQLGKKLAQVLGSGAGSPLTPGTMEPCAAGSGSPLANGELFNVSKA------KKVE 354
            :..|:.|..:|...:|.|.......:.|....|       |..|.|.....:..|      :|..
Frog   279 TEQDDLLSDIQQAIRLQQATCDSDTTNLLSKVM-------GGTLTNSHTLFLDAAEHLVAPEKEN 336

  Fly   355 LQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQ 419
            :|.......|.:.|...|:|.:.....|:|..:.|    |..|.|:.|:|..|..:.| |||.|:
Frog   337 VQLAGPCPPAPIAQGQQGLTGTGDTGLGLTEVSDP----TQEPPLDEQATAQIHIQVS-TPVTSK 396

  Fly   420 --TNSAASENVED--------------------------DTAPLPLPPPPPG----------FGT 446
              .|:|..::..|                          |||.:.:......          ..|
Frog   397 EGENAAGLQSDTDNETIRLEGSNGDLAVHSIFYESCQSKDTADMSIHNQRLNGSTDLADCAMNST 461

  Fly   447 PTTPLLSSN---------VLKKVASFTVEKSSAGNNS-----SNPP------------------- 478
            ||||.|::|         :.......|..:.|:.|:|     |:.|
Frog   462 PTTPQLATNHSGVKPYPPINPCYIKTTTRQLSSPNHSPFASPSHSPQLYRKQGQTFKHESAIRKK 526

  Fly   479 -------NLCPTSDETTLLATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFA 536
                   |:..::|.|..|....:..|........:..||...|........|.||......||.
Frog   527 RSCSLVGNISRSADWTEELIKDQNKPLRKGNSSDFLLFGANGKGAESLPSDSRKSSIQASASSFP 591

  Fly   537 AYEKFEGQMLIKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDC---- 597
              ..|.|:.|::.|.:..::.|:.             |.:.|:.:..||:|...|    ||
Frog   592 --NVFTGRTLLEKLFNQQKNAPEE-------------AEKLCSQIIAVGLLLPFS----DCFREQ 637

  Fly   598 ----------GFSPYEMYQWTHTEQPTTSLPLTPGKLDK--VAAWPFSSTPSGIRALESASLASL 650
                      .|...::|.|....|||.||....|:..:  .|||| ..|.:.:|..|..|
Frog   638 CSKSAPQIPSTFDQDQLYTWAAVSQPTHSLDYLEGRFPRRIQAAWP-PVTKATVREEEHQS---- 697

  Fly   651 GAGGVAGSLATIATASTASSDNQKTLQQILKKR--LLNCTTLAEVH-AVVNELLSSVDE------ 706
                           ..:..:|:...:.:.||.  .|..:.|.|.| .::.:|..::::
Frog   698 ---------------HDSEVENKAKEESVPKKEDSELPYSLLKEDHIQIIQQLEQTIEDLRTKLA 747

  Fly   707 ------------------PPRRPS-----------KRCV-----------------NLTELLNAS 725
                              |...||           |:||                 :|:.|....
Frog   748 EREKQNGQANISAWEQIKPSTEPSTEVEDEWHISLKKCVEGKSVQTSPVEELQEVPSLSILAQLD 812

  Fly   726 EATVYEYNK---------TGAEGCVKSFTDAETQTESEDCE---------GTCKCGQSSTKVSDN 772
            .|...:|.|         :....|.:.......:..|:..:         ...:.|..|..:||:
Frog   813 SAARNKYMKQLPSSLELPSHLTYCSELSVVLSPKPNSQQIDSNIFTDILASALQTGSVSLPMSDS 877

  Fly   773 ESAK--------------------EDGEK------------PHAVAPPPP------------PPP 793
            ...|                    |:..:            .|...||||            |||
Frog   878 SDHKHILSRIPTPPPLPFVSINNLENASQMLPDKHDLGPCTTHIPPPPPPAPPSSFIPGIGVPPP 942

  Fly   794 PPL---------H-------------AFVAPPPPPPPPP--------PPPPPLAN----YGAPPP 824
            |||         |             ||..|||||||.|        ||||||.|    ..||||
Frog   943 PPLPSNLYFDSQHPMPPPPPPLPNGTAFPCPPPPPPPLPLSLFGSGIPPPPPLPNGISILNAPPP 1007

  Fly   825 PPPPPP-----GSGSA--------------------------------PPPPPPAPIEGGGGI-- 850
            ||||||     |..||                                ||||||.|...|.|.
Frog  1008 PPPPPPLPPDIGMASAAGFPVPPPPAPPLPPGMGVSPSLPSSIGMPPPPPPPPPPPFPLGIGSRP 1072

  Fly   851 ----------PPPPPP-----MSASPSKTTIS-PAPLPDP-------------------AEGN-- 878
                      ||||||     :.:|||....| |||.|.|                   .:|:
Frog  1073 TSPSMGNYRPPPPPPPLPVAFLGSSPSPLPCSGPAPPPPPPPPPFPGSVPIPPRFLASHVQGSVL 1137

  Fly   879 -----------------------WFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVAN 920
                                   ..::....||:.:.|.|||:|||||||
Frog  1138 PSFGCAPALGCLTPPLPAGLFAFGLNQDKGYRKAPIEPSKPMKPLYWTRI--------------- 1187

  Fly   921 STDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSRQAIAPVSKPK 985
                 |..|......|.                :|..:.|..:| ..|...|||:.|:....||.
Frog  1188 -----ELHGKRDSNIPL----------------VWEAVSEPKVD-FHELENLFSKTAVKERKKPI 1230

  Fly   986 E---LKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATE 1047
            .   .|.|..:.:|:|..:||:.|||:..|||:...:|:||:..:|.|||.||.||.:...:|..
Frog  1231 SDTITKTKAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVLKMDYSVVDLETLQALFENRAVP 1295

  Fly  1048 DELQRI------KEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETV 1106
            :|.::|      .:......|||.|||||.:::.|...:||:.||:..:...||.:.|.||||.:
Frog  1296 EEQEKIDKHVKASKTKDQSKPLDKPEQFLYELTTIPNFTERVFCILSHSTISESTSSLRRKLELL 1360

  Fly  1107 SQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIV 1171
            .::.:.|.|...|: |..::|..|||||||||.|||||||.||||.|||||||.::...||.:||
Frog  1361 QKVCETLREGPVLR-VLGLVLAFGNYMNGGNRTRGQADGFALDILPKLKDVKSNDNSRNLLSYIV 1424

  Fly  1172 RTYIAQRRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRP 1236
             :|..:...|.....:....:|||.|:.:.:||.||:.|:.:....|.|..|:....||...|..
Frog  1425 -SYYLRHFDENAGKEDCVFTLPEPQDLFQTSQMKFEDFQKDLRKTKKDFQACETEADKVYQKSLE 1488

  Fly  1237 EIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYW 1301
            |.::|||..||.|:..|...:....:.|.|....||||..::...||   :...:.:|:.||..|
Frog  1489 EHLQPFKDNMEVFLSKAKIELEDTEKFLTEVHSRFLETTSYFCVKPK---IGEKEVSPNSFFSIW 1550

  Fly  1302 TNFTNDFKDIWKKEITSLLNELMKKSKQAQIESRRNVSTKVEKSGRISLKERMLMR 1357
            ..||.||||.||||...:|.|.:|::::...:.:...|..|:......:|.::.:|
Frog  1551 HEFTTDFKDFWKKENKLILQERLKEAEEVYKQKKEKTSIIVKPKHESGIKAKLSLR 1606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	152/435 (35%)
fmn2	XP_002935863.3	FH2	1169..1558	CDD:396655	148/430 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I2123
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002764
OrthoInspector	1	1.000	-	-		otm48309
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050