DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and Inf2

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_030102765.1	Gene:	Inf2 / 70435	MGIID:	1917685	Length:	1285	Species:	Mus musculus

Alignment Length:	783	Identity:	206/783 - (26%)
Similarity:	320/783 - (40%)	Gaps:	153/783 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 KVAAWPFS----STPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLL- 685
            ||:..|.|    |...|:..||.|        |.:|.|.            .:.|:.::.:.:|
Mouse   281 KVSCSPASAQLLSVLQGLMHLEPA--------GRSGQLL------------WEALENLVNRAVLL 325

  Fly   686 ----NCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEYNKTGAEGCVKSFTD 746
                ...||.|   ||..|||....|  |||.        |:.:..:|...:........::.|.
Mouse   326 ASDAQACTLEE---VVERLLSIKGRP--RPSP--------LDKAHKSVQTNSVQNQGSSSQNTTT 377

  Fly   747 AETQTESED------CEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPP--------PPPPPPLH 797
            ..|:.|.:.      |:.......||..::....|.|.......:..||        ||.||||.
Mouse   378 PTTKVEGQQPVVASPCQHVGSIQSSSVDIAPQPVALEQCITALPLPTPPLSSSTPVLPPTPPPLP 442

  Fly   798 AFVAPPPPPPPPPPPPPPLANYG--APPPPPPPP-------PGSG--SAPPPPPPAPIEGGGGI- 850
            ...|..|.||||||.||||...|  :||||||||       ||||  |.||||||.|:.|.|.:
Mouse   443 GPGATSPLPPPPPPLPPPLPGSGTTSPPPPPPPPPPLPPPLPGSGTISPPPPPPPPPLPGTGAVS 507

  Fly   851 PPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRP 915
            ||||||:.:.|......|.| |.|..|          ...|.||.|:     .|.....||.|.|
Mouse   508 PPPPPPLPSLPDSHKTQPPP-PPPLPG----------MCPVPPPPPL-----PRAGQIPPPPPLP 556

  Fly   916 ----PS--------VANSTDSTENSGSSPD----EPPA-----ANGADAPPTAPPATKEIW---- 955
                ||        :....|.:..|...|.    .||.     .|....|.........:|
Mouse   557 GFSVPSMMGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLG 621

  Fly   956 ---TEIEETPLDNIDEFTELFSRQAIAPVSKPKELKV----KRAKSIKVLDPERSRNVGIIWRSL 1013
               |...|....:|:   :|||    .|.:||||...    |..|.:..||.::|.|:.|..:..
Mouse   622 SPCTAAVEPDFSSIE---QLFS----FPTAKPKEPSAAPARKEPKEVTFLDSKKSLNLNIFLKQF 679

  Fly  1014 HVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDHPEQF---LLDISL 1075
            ...:.|:...|...|||...:|.|:.:..:...:.|::.::........|.:.:||   ||||..
Mouse   680 KCSNEEVTSMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPC 744

  Fly  1076 ISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQR 1140
            ..:   |:.|::........:.::..|.:.|....:.|:.|:.|.:...:||.:||::|.|: ..
Mouse   745 YPL---RVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILKIGNFLNYGS-HT 805

  Fly  1141 GQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHP--LEIRLPIPEPADVERAAQ 1203
            |.||||.:..|.||.:.||::|..||||.::      ...|..||  |::...:..|:   :||.
Mouse   806 GDADGFKISTLLKLTETKSQQSRVTLLHHVL------EEVEKSHPDLLQLSRDLEPPS---QAAG 861

  Fly  1204 MDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECR 1268
            ::.|.:..:.....||.|..:|.    ::||.||:.:.:..:::..:| |.:.:.|:..::::.:
Mouse   862 INVEIIHSEASANLKKLLEAERK----VSASIPEVQKQYAERLQASIE-ASQELDKVFDAIEQKK 921

  Fly  1269 DLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIE 1333
               ||...:....|:..:|.....|...|.:.:|....:.||  :||  .:.....:|.:.|:.|
Mouse   922 ---LELADYLCEDPQQLSLEDTFSTMKTFRDLFTRALKENKD--RKE--QMAKAERRKQQLAEEE 979

  Fly  1334 SRR 1336
            :||
Mouse   980 ARR 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	108/463 (23%)
Inf2	XP_030102765.1	Drf_GBD	<14..152	CDD:368864
		Drf_FH3	156..341	CDD:368862	19/82 (23%)
		FH2	587..951	CDD:388631	91/391 (23%)
		WH2	1005..1020	CDD:128542
		PHA03307	1034..>1278	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810