Protein Alignment capu and grid2ipa

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_009297619.1
• Gene: grid2ipa / 561017
• ZFINID: ZDB-GENE-091113-42
• Length: 1804
• Species: Danio rerio
• Alignment Length: 1811
• Identity: 305/1811 - (16%)
• Similarity: 520/1811 - (28%)
• Gaps: 702/1811 - (38%)

  Fly    17 PGGASLVRMGITGGGGAGEVG-------------VALSERRGSRVRVLSRLMGQKR----IREAF 64
            |.|    |.|:..|....||.             :..|:.|..|:.||.....|||    ::|.:
Zfish   160 PAG----RSGLRAGDYVLEVNGIPVKQHETAAAMIKASQGRTLRLGVLRINRWQKRTSSSMKETY 220

  Fly    65 LHSPKLGSSSEVNLQGAGNGSSDW-------IAAETEVEHGQLDCSAEPADFHDVVSLDCTDSLE 122
                   .|.||..|...:.:.::       :..|.||:....|...:.|:..||..|..|
Zfish   221 -------HSGEVVRQDRKHKALEFNKKVEEILGEEPEVKERLFDLLKQYANERDVEGLAST---- 274

  Fly   123 YHNCSSDECCYASNDTLTERQNRELQQRQRQHHHHHHHIHNAH---ESHHHYPYDRRSLCTSCSS 184
                       .....|||              .|...|.|..   ...|...:|
Zfish   275 -----------LPEILLTE--------------EHQQLIDNIRIFIPKKHRQRFD---------- 304

  Fly   185 NDSLFTDPVDELIISKHYLNTAAKEHNNPKAKR----DRPLSEISVTSVDTLSPNTA--KAVLEL 243
                  :.|.:.:||: ....:..||.|.:.:|    |.|...:||::..:..|.||  :.|:..
Zfish   305 ------EMVSQSLISR-LRGRSFSEHRNNRLRRSRSEDHPERLLSVSTRASSVPRTANDEVVMPP 362

  Fly   244 QKRCR------ADKLACLSLTRVTYLSIANDLQEVEEPDRASILHDTDLLVAPNSPAESS---PD 299
            .:..|      |...:..|..|...:...|..........|.:..|:   |.|.||||.:   |.
Zfish   363 ARGLRKTTSLIAGHSSSFSTRRTVRVYKGNQSFGFTLRGHAPVWIDS---VIPGSPAEKAGLKPG 424

  Fly   300 EELMALQLG---------KKLAQVLGSGAGSPLTPGTMEPCAAGSGSPLANGELFNVSKAKKVEL 355
            :.::.|. |         |.::.:.||||        |.......|.|     .|.:::.::||
Zfish   425 DRILFLN-GLDMRSCSHEKVVSMLQGSGA--------MPSLVVEDGPP-----AFTMTEPEQVE- 474

  Fly   356 QNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQT 420
              :|.|..|.|..:...|....|....|.|       .|.|..||.    :::.:...|..::..
Zfish   475 --VSPRSRAPVLSSLQWVAEILPPSIRVQG-------RTFSQQLEH----LLTLQERYTICKALE 526

  Fly   421 NSAASENVED---DTAPLPLPPPPPGFGTPTTPLL------------SSNVLKKVASFTVEKSSA 470
            ......||:.   |..|:        ..||...::            ..:...|::.|...|.:.
Zfish   527 AFFQHRNVDTLIVDVFPV--------LDTPAKQVIWQFVYQLLTYEEQEHCQNKISRFLGYKVTL 583

  Fly   471 GNNSSNPPNLCPTSDETTLLATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSF 535
            ......||...|....:::..|..:...:|.        |.::..:.  .|:..|.....|.:..
Zfish   584 PAAEPEPPAHEPHRRSSSMKVTGTTYRSSVR--------GRSSDDLV--IGTHLGMGICTEPVEA 638

  Fly   536 AAYEKFEGQMLIKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFS 600
            |......|:.             :|..|.:..|..|.|     .||.  .|..::.|
Zfish   639 APMRLTPGER-------------QSGDGTSLPETPNNL-----TNLS--AVYAELEN-------- 675

  Fly   601 PYEMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATA 665
               :|....::...:..|..|..|..|..:|.:::.| :||..|                |.:..
Zfish   676 ---VYAGKRSKSLKSRPPPAPDTLVSVDVFPHTTSQS-VRAHSS----------------TPSVR 720

  Fly   666 STASSDNQKTLQQI--------------LKKRLLN----C-------TTLAEVHAVVNELLSSVD 705
            :|:.|....:.|.:              :::..|:    |       .|.||.:..:     |:|
Zfish   721 ATSGSRKSGSAQHVPPPPPPPPPEPDPWMQETPLSPQCPCYPPGLPSQTSAESNPYI-----SLD 780

  Fly   706 EPPRRP------------SKRCVNLTELLNASEATVYE---YNKTGAEGCVKSFTDAETQTESED 755
            .||..|            .|:....:.....::..::.   ..:.|.:..|..|...|...|.:.
Zfish   781 SPPLSPPSPPDYPPSPPIRKKRYTFSRPPRTADTDLFMEALSEQLGQQLSVDDFLSPENDYEEDV 845

  Fly   756 CEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPPPP---------------------------PP 793
            .:.|.:..:...:| |.|..:|:.|:.....|..||                           ||
Zfish   846 VQMTFQDEEEEVEV-DEEEEEEEEEEEEEEGPYMPPELSSPSEVHSSSEDASSLTYSSSSEHIPP 909

  Fly   794 PPLHAFVAPPPPPP-----PPPP-------PPPPLANYGAPPPPPPPPPGSGSAPPPP------- 839
            |||    .||||||     ||||       .|..|.....|.|||||||   .|.|||
Zfish   910 PPL----TPPPPPPVQFNDPPPPAGFTPEHAPRQLTFRRHPGPPPPPPP---RANPPPKRQSIHK 967

  Fly   840 ---------------------PPAPIEG---------GGGIPPPPPP------------------ 856
                                 |..|..|         ...:||.|.|
Zfish   968 VLPTRDELMSQQQLLQEHHSLPVQPTAGHPQQSQQQMHQSLPPMPSPEINQTSISGHAIYEMQSQ 1032

  Fly   857 ---------------------------------------MSASPSKTTIS--------------- 867
                                                   .|..|.:|.:|
Zfish  1033 VHPAHQVHQHPQMQQDHQMHQFHQHKRHQSQSIKVHHSHRSHQPIQTQLSSSMDRLDRIDRNPDR 1097

  Fly   868 ------PAPLP---------DPAEGNWFHRTNTMRK----------------------------- 888
                  |.||.         :..:.:..|.|::|.:
Zfish  1098 LIYEMQPQPLHSDQQVHHAYEMHQSHQAHLTSSMDRLDRLEQIQHLERLERMERIERLERADRQM 1162

  Fly   889 ----------SAVNPPK---------------------PMRP------------LYWTRIVTSAP 910
                      .||.||:                     |.:|            ::..:.:.|||
Zfish  1163 HRAHMAQALSQAVQPPQQSQQQYNQQQYQMHQSNQDYPPTQPPPPTRHIHQIEHIHQVQPIQSAP 1227

  Fly   911 ----------------------------------------------------------------- 910
                                                                             
Zfish  1228 QYHQIHQPHQPHQTQQILSTFQPHPSQLQQQQQLLQQQLQQQQQQQLQQQQQRQQQQQLQQLEQQ 1292

  Fly   911 -----------------------------------PAPRPPSVANSTDS---------------- 924
                                               ..|:.||||.:..|
Zfish  1293 QQLQQLEQQQQLQQQQIQQQQAQQQQQIQQQQQHRSTPQIPSVAQARQSPQPMYHEHRHHHHHRS 1357

  Fly   925 ---------------------TENSGSSPDEPPAANGADAPPTAPPATKE--------------- 953
                                 ||.|...|..||.......||..|..:.:
Zfish  1358 HHEAQSQMQPPISPQPQTHNPTEGSSVEPPPPPPLPPPCVPPPLPKGSPQKSDSSHMSVKRLRWE 1422

  Fly   954 --------IWTEIEE----TPLDNIDEFTEL---FSRQ---AIAPVSKPKELKVKRAKSIKVLDP 1000
                    ||.::||    ..|.::.::.:|   |..|   ...|...|:....|:...:::|..
Zfish  1423 QVENSEGTIWGQMEEDSDYDKLSDMVKYLDLELHFGTQKTPVALPEPSPQVETFKKKDVVEILSH 1487

  Fly  1001 ERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDH 1065
            :::.|..|:...|.:...|:...:..:.:..:....::.:......:||:::.::.......|..
Zfish  1488 KKAYNASILIAHLKLSPGELRQVLMTMSSERLEPPHIKQLLLYAPDDDEVRQYEQYRNDPGKLSE 1552

  Fly  1066 PEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLG 1130
            |:||:|.:..:.....|:..:.|:...:|....:....:.|.:.|.:|..|:.|..:...:|.:|
Zfish  1553 PDQFVLQMLSVPEYKTRLKSLHFKTTLQEKTEEMRGAYDCVFKASLELKNSKKLAKILEFVLAMG 1617

  Fly  1131 NYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEP 1195
            ||:|.|..:.|:..||.::.|.:|...|:.:..:|.||.:|:: :.|...|.:...:..:.:|:.
Zfish  1618 NYLNNGQPKTGKTTGFKINFLTELSTTKTVDGKSTFLHILVKS-LCQHFPEVLDFGKELVMVPQA 1681

  Fly  1196 ADV-ERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAK 1259
            |.| :|....||.::...|.|:.   :.|::..|  .|..|      |...|..|:|.:..::..
Zfish  1682 AKVNQRNITSDFNDLHATIQDIR---VACQKMPA--TAEDR------FAVVMSGFLENSHPAVQS 1735

  Fly  1260 LHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFF----EYWTNFTNDFKDI 1311
            |........:.|.:...::....|.       .|.:.||    |:...|.....||
Zfish  1736 LESLQQRAMEEFCKVASYFGEDGKT-------TTTENFFGIFAEFIAKFERTLSDI 1784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	99/671 (15%)
grid2ipa	XP_009297619.1	PDZ1_L-delphilin-like	49..124	CDD:467225
		PDZ_canonical	131..202	CDD:483948	10/45 (22%)
		HN_L-delphilin-R1_like	230..309	CDD:259820	18/123 (15%)
		PDZ2_L-delphilin-like	385..459	CDD:467226	18/85 (21%)
		HN_L-delphilin-R2_like	498..577	CDD:259821	14/97 (14%)
		FH2	1406..1778	CDD:396655	72/390 (18%)