DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and daam1b

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001025307.1	Gene:	daam1b / 560060	ZFINID:	ZDB-GENE-030131-4212	Length:	1079	Species:	Danio rerio

Alignment Length:	1052	Identity:	230/1052 - (21%)
Similarity:	400/1052 - (38%)	Gaps:	302/1052 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 NVLKKVASFTVEK----SSAG------NNSSNPPNLCPTSDETTLLATPCSSSLTVATLPPEIAV 509
            |.||.:...|.|.    |..|      |||....::...::...::|    .||....:..::||
Zfish   163 NFLKSMDYETTESQIHTSLIGCIKALMNNSQGRAHVLSHTESINIIA----QSLATDNIKTKVAV 223

  Fly   510 GAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSGDANQEL-FNTL 573
            ....|.|....|   |...:.|  :...|:||..:   :....|:.::...|:|....|: ..|.
Zfish   224 LEIMGAVCLVPG---GHKKILE--AMLHYQKFACE---RTRFQTLLNDLDKSTGRYRDEVSLKTA 280

  Fly   574 ALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTPSG 638
            .:.|.|     .||.|      ..|.|..|..  .|.......|.:.| .:||
Zfish   281 IMSFIN-----AVLSQ------GAGESSLEFR--VHLRYEFLMLGIQP-IIDK------------ 319

  Fly   639 IRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLLNCTTLAEVHAVVNELLSS 703
            :|:.|:::|.           ..:.......:|::.||.:..:...::..:..:|..:|.:.|:.
Zfish   320 LRSHENSTLD-----------RHLDYFEMLRNDDELTLSRRFEAIHIDTKSATQVFELVRKKLAH 373

  Fly   704 VDEPPR----------RPSKRCVNLTE-------------------------------------- 720
            .|..|.          .|.||..|..:
Zfish   374 TDAYPHFMSVLHHCLLMPHKRSGNTVQYWLLLDRIVQQMVLQNDKGHDPDATPLENFNVKNVVRM 438

  Fly   721 LLNASEATVYEYNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGEKP--- 782
            |:|.:|...:   |..||...|...:.:.:.|.::.|...|..:....:......||..|:.
Zfish   439 LVNENEVKQW---KEQAEKMRKDHHELQQKMEKKERECDAKTQEKEEMMQTLNKMKEKLEREMGE 500

  Fly   783 ---------------H-------AVAPPPPPPPPPLHAFVAPPPPPPP-----PPPPPPPLANYG 820
                           |       |..|..||...||...:.|||||||     |||||||.....
Zfish   501 HKLVKQQVAEMTTRLHELSTRQIASVPGGPPVSGPLGGPLLPPPPPPPPGGMMPPPPPPPPCGAM 565

  Fly   821 APPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNT 885
            .||||||||.|    |||||..|..|..   ||||.....||                      .
Zfish   566 MPPPPPPPPGG----PPPPPGRPPFGSA---PPPPGAPIGPS----------------------L 601

  Fly   886 MRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPA 950
            .:|:...|..|::...|.::               |.:..|.:
Zfish   602 KKKNIPQPSNPLKSFNWAKL---------------SENKLEGT---------------------- 629

  Fly   951 TKEIWTEIEE------TPLDNIDEFTELFSRQA---IAPVSKPKE-----LKVKRAKSIKVLDPE 1001
               :|.::::      ..|::|::....:.||.   :...:|.||     |..|:.|.:.|:|..
Zfish   630 ---VWADVDDGRVFKILDLEDIEKTFSAYQRQQDFFMVNNNKQKETEDDTLSSKKVKELSVIDGR 691

  Fly  1002 RSRNVGIIWRSLHVPSSEIEHAIYHIDTSV-VSLEALQHM-------SNIQATED---ELQRIKE 1055
            |::|..|:...|.:.:.||:.||..:|... :..:.|:.|       |::...|:   ||.|:.:
Zfish   692 RAQNCNILLSRLKLSNEEIKRAILTMDEQEDLPKDMLEQMLKFVPEKSDVDLLEEHKHELDRMAK 756

  Fly  1056 AAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLK 1120
            |          ::||.::|.|:...:|:..:.|:.:|.|.:..:..|:|.:::.|::::.|.:.|
Zfish   757 A----------DRFLYEMSRINHYQQRLQSLYFKKKFAERIAEIKPKVEALTKASKEVLHSRNFK 811

  Fly  1121 LVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSK-ESHTTLLHFIVRTYIAQRRKEGVH 1184
            .:..::|..|||||.|  |||.|.||.:..|.|:.|.||. :.:.||||:::.  |.:::..
Zfish   812 QLLEVVLAFGNYMNKG--QRGNAYGFKISSLNKIADTKSSIDKNITLLHYLIT--ILEKKYS--- 869

  Fly  1185 PLEIRLPIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKV-LAASRP-EIMEPFKSKME 1247
              ::.|...|..:|..||:::..|::::|.:|..   |.|...::: ....|| |..:.|.|.:.
Zfish   870 --KVMLFQEELKNVPEAAKVNMTELEKEINNLRS---GLKSVESELDFQKKRPQEYGDKFVSVVS 929

  Fly  1248 EFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIW 1312
            :|:..|..|.:.:..||.|.::||::|::  ||...|     .:..||:||..:..|...|.:..
Zfish   930 QFITVASFSFSDVEDSLCEAKELFIKTVK--HFGEDA-----DKMQPDEFFGIFDQFLQSFAEAR 987

  Fly  1313 KKEITSLLNELMKKSK---------QAQIESRRNVSTKVEK--------------------SGRI 1348
            ::      ||.:::.|         :||::.:|....|..|                    ||.:
Zfish   988 QE------NENIRRRKEEEERRARMEAQLKEQREKERKARKAKENGEDDGGEFDDLVSALRSGEV 1046

  Fly  1349 SLKERMLMRRSK 1360
            ..|:...|:|::
Zfish  1047 FDKDLSKMKRNR 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	105/454 (23%)
daam1b	NP_001025307.1	Drf_GBD	45..232	CDD:283920	17/72 (24%)
		Drf_FH3	235..439	CDD:283917	39/248 (16%)
		FH2	603..983	CDD:280362	104/448 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810