DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and grid2ipb

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1553	Identity:	304/1553 - (19%)
Similarity:	511/1553 - (32%)	Gaps:	493/1553 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VDEKSP--PGGASLVRMGITGGGGAGEVG-------------VALSERRGSRVRVLSRLMGQK-- 58
            |::.||  |.|    |.|:..|....||.             :..|:.|..|:.||.....||
Zfish   105 VEDCSPCSPAG----RSGLRAGDYVMEVNGIPVKHHEMAAALIKASQGRTLRLGVLCMGSRQKRS 165

  Fly    59 ---------------------------RIREAFLHSPKLGSS-SEVNLQGAGNGSSDWIAAE--- 92
                                       |:.|...:.|::... ..|..|.|.....||:|:.
Zfish   166 SGSLEGLQKDTDGMRQDRKHKALEFNRRVEEILRNEPEVKEKLFAVLKQFAAERKVDWLASVLPD 230

  Fly    93 --TEVEHGQLDCSAE---PAD----FHDVVSLDCTDSLEYHNCSSDECCYASNDTLTERQNRELQ 148
              |..|..||..:..   |..    |.:.||    .||....|.|        .:|.|.|||..:
Zfish   231 ILTTEEQQQLISNIRIFIPKKHRQRFDEAVS----QSLINRMCRS--------KSLGEPQNRLRR 283

  Fly   149 QRQRQHHHHHHHIHNAHESHHHYPYDR--------RSLCTSCSSNDSLFTDPVDELIISKHYLNT 205
            .|.:.||........|..    .|.|.        |:|..|.:...:.:...|::..|..:
Zfish   284 SRSQDHHERPQGSKRASS----VPRDTGDEPAQNDRTLRKSNTMIPTQYVSGVNQRTIRVY---- 340

  Fly   206 AAKEHNNPKAKRD-----RPLSEISVTSVDTLSP------NTAKAVLEL----QKRCRADKLACL 255
                    :.|:.     |..:.:.:.||...||      .|...:|.|    .:.|..:|:..:
Zfish   341 --------RGKKSFGFTLRGHAPVWIDSVMPGSPAEACGLKTGDRILFLNGLDMRNCSHEKVVSM 397

  Fly   256 SLTRVTYLSIANDLQEVEEPDRASILHDTDLLVAPNSPAESSPDEELMALQLGKKLAQVLGSGAG 320
            ........|:..:...|:.|...|...:|     |::|...||  .|.:||.   :|::|
Zfish   398 LQGSGAMPSLVVEEGPVDYPQSDSEPEET-----PSAPRSRSP--ALSSLQW---VAEIL----- 447

  Fly   321 SPLTPGTMEPCAAGSGSPLANGELFNVSKAKKVE-LQNLSSRFT---------------AAVTQT 369
                |.::.          .:|..|    ::::| |..|..|:|               ..:...
Zfish   448 ----PPSIR----------VHGRTF----SQQLEHLLTLQERYTICKALETFFQHRNVDTLIVDV 494

  Fly   370 PPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAAS--------- 425
            .|  ...||.:..:......|.........:|:....:.|||::..|.::|:..:|
Zfish   495 FP--VLDTPAKQLIWQFIYQLLTYEEQEHCKTKIARFLGFKSAEPEVGAETHRRSSSMRVSGTSH 557

  Fly   426 -----ENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVASFTVEKSSAGNNSSNP--PNLCPT 483
                 |...||.    :.....|.||.|.|:            |.|:...|:.:|.|  |:|...
Zfish   558 KNTVRERSSDDC----IIGTHLGMGTFTDPV------------TPEERQCGDGTSFPESPDLSHM 606

  Fly   484 SDETTLLAT--PCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQML 546
            :...|.|..  |..||.::.         :.:...|.|.|....::|.
Zfish   607 TGVYTELGNVYPVKSSQSLQ---------SHSSPRAAGMGLAESNTYT----------------- 645

  Fly   547 IKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWT--- 608
                    ||...|::|:....|..|                                  ||
Zfish   646 --------QSFTHSTAGNRKSGLSLT----------------------------------WTDSF 668

  Fly   609 -----HTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTA 668
                 .|.|.|.:.|      |.|.:.|:.|..|                         ..||..
Zfish   669 PGPQFETYQQTVASP------DSVDSNPYVSLDS-------------------------PPASPL 702

  Fly   669 SSDNQKTLQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPR-RPSKRCVN-LTELLNASEATVYE 731
            .||....|.|..|                   |.:...||| |.:.:.:: |:|.|......|.:
Zfish   703 PSDELSPLPQRRK-------------------LFTFSRPPRSRDTDKFLDALSEQLGHRVNIVDD 748

  Fly   732 YNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGE-------KPHAVAPP- 788
            :.  |.|      .|.|..:..::.|......:.|:..|::.|:.:|..       ..|...||
Zfish   749 FK--GGE------NDYEEMSFQDEQEVNMLPHELSSASSEDHSSSDDSTSVSYSSGSDHIPPPPQ 805

  Fly   789 -PPPPPPPLHAFVAPPPPPPPP---PPPPPPLANYG--APPPPPPPP------------------ 829
             ||||||||....:|.|.|..|   |.|||...::.  |||||||.|
Zfish   806 SPPPPPPPLQFTDSPSPLPITPEHLPQPPPAFQHHPIIAPPPPPPRPFLANRPSLHKVLPTREEL 870

  Fly   830 ------PGSGSAPPPPPPA---------PI-EGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGN 878
                  |...|..|...|.         || :......|.||..||..::       |..|::..
Zfish   871 RAQHSHPRRSSPQPSSQPILQLHQPKAHPILQSSPHTSPQPPHTSAQHTR-------LQHPSQSI 928

  Fly   879 WFHRTNTMRKSAVNPPK-------PMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPP 936
            :..:..|:.:::.:..|       |.:..:...:.:..||.|.||.                 ||
Zfish   929 YQSQQTTVPRTSPSLTKQKSLHSQPSQQSFEGTLSSKVPPPPPPPL-----------------PP 976

  Fly   937 AANGADAPPTAPPATK----------------------EIWTEIEETP----LDNIDEFTEL--- 972
            .   .|.||...|:.|                      .||.::.:.|    |.::.::.:|
Zfish   977 P---CDPPPLPKPSPKASDNNHMSVKRLRWEQVENSEGTIWGQLGDDPDYHKLSDMVKYLDLDLY 1038

  Fly   973 --FSRQAIA---PVSKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVV 1032
              ..|.:|:   |...|:.||.|..  :::|..:::.|..|:...|.:...|:...:..:.|..:
Zfish  1039 FGTQRNSISLPEPTFLPENLKKKDV--VEILSHKKAYNASILIAHLKLAPKELRDILMTMSTERL 1101

  Fly  1033 SLEALQHMSNIQATEDELQRIKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVT 1097
            ....::.:......::|:::.:........|..|:||:|.:.|:.....|:..::|:...:|...
Zfish  1102 EPAHIKQLLLYAPDDEEVKQFQHYDQDPAKLSEPDQFVLQMLLVPEYKTRLRSLLFKTTVQEKTE 1166

  Fly  1098 LLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKES 1162
            .:....|.:.:.|.:|..|:.|..:...:|.:|||:|.|..:..:..||.::.|.:|...|:.:.
Zfish  1167 EMRAAYECIYKASLELKNSKRLAKILEFVLAMGNYLNNGQPKTNKTTGFKINFLTELNTTKTVDG 1231

  Fly  1163 HTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADV-ERAAQMDFEEVQQQIFDLNKKFLGCKRT 1226
            .:|.||.:.:: :.|...|.:......:.:|..|.| :|....|..:|...|.|:.
Zfish  1232 KSTFLHILAKS-LCQHFPELLGFSRDLITVPLAAKVNQRTITADLSDVHSTIQDIR--------- 1286

  Fly  1227 TAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQ 1291
            ||.|...:..|  :.|.:.|..|:|....::    ||||                      :|.|
Zfish  1287 TACVKIPATAE--DRFAAVMSSFLENCHPAV----QSLD----------------------SLQQ 1323

  Fly  1292 CTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIESRRNVSTKVEKSGRIS 1349
            ...|:|.:..:.|..|.|....:....:..|.:.|.::|..|::   .|:..||.||:
Zfish  1324 RAMDEFHKVASYFGEDSKVTTTETFFGIFAEFISKFERALSETQ---GTENPKSPRIA 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	90/468 (19%)
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492	13/54 (24%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	17/82 (21%)
		PDZ_signaling	335..410	CDD:238492	13/86 (15%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	12/94 (13%)
		FH2	995..1360	CDD:280362	78/404 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810