Protein Alignment capu and Fmnl2

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_038962712.1
• Gene: Fmnl2 / 499797
• RGDID: 1560248
• Length: 1098
• Species: Rattus norvegicus
• Alignment Length: 1037
• Identity: 234/1037 - (22%)
• Similarity: 391/1037 - (37%)
• Gaps: 279/1037 - (26%)

  Fly   402 QSTVIISFKSSQTPVQSQTNSAA--SENVEDDTAPLPLPPP-------------------PPGFG 445
            |..|...|:|.::.|:|..:.:.  |.::||......||.|                   |....
  Rat   144 QYAVTFDFESVESTVESTVDKSKPWSRSIEDLHRGNNLPSPVGNSVSRSGRHSALRYNTLPSRRT 208

  Fly   446 TPTTPLLSSN--------VLKKVASF------------TVEKSSAGNNSSNPPNLCPTSDETTLL 490
            ...:.|:|..        .|:.:.::            .|.:.:...|:.||.......:   ||
  Rat   209 LKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLE---LL 270

  Fly   491 ATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIKWLISTMQ 555
            |..|.                    |.||           .::..:|::.|:.....|.....:.
  Rat   271 AAVCL--------------------VRGG-----------HEIILSAFDNFKEVCGEKQRFEKLM 304

  Fly   556 SNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWT------------ 608
            .:.::...:.:   |...::||.|.:.:       |.|  |..|..:..|::|
  Rat   305 EHFRNEDNNID---FMVASMQFINIVVH-------SVE--DMNFRVHLQYEFTKLGLDEYLDKLK 357

  Fly   609 HTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQ 673
            |||.....:.: ...||.|    |.                      .|:|...|....|:.:..
  Rat   358 HTESDKLQVQI-QAYLDNV----FD----------------------VGALLEDAETKNAALERV 395

  Fly   674 KTLQQILKKRLLNCTTLAE-VHAVVNELLSSVDEPPRRPSKRCVNL---TELLNASEATVYEYNK 734
            :.|::       |.:.|:| :....||.:|.:.|..::..:|...|   .|:...:...|:...|
  Rat   396 EELEE-------NISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRK 453

  Fly   735 --TGAEGCVKSFTDAETQTESEDCEGTCKC---GQSSTKV------------SDNESAKEDGEKP 782
              ...|..::..:..|.:....:.:||.|.   |.....:            ||.......|..|
  Rat   454 MVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLPMGSDLAGGNYVGPVP 518

  Fly   783 HAVA-----PPPPPPPP----PLHAFVAP--PP--PPPPPPPPPPPLANYGAPPPPPPPPPGSGS 834
            .|.:     |||||.||    |..|...|  ||  |||||||||||      |||||||.||..:
  Rat   519 GAASSGPSVPPPPPLPPSSDTPEAAQNGPASPPMSPPPPPPPPPPP------PPPPPPPLPGPAA 577

  Fly   835 APPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDP--AEGNWFHRTNTMRKSAVNPPKPM 897
            ...|.||        :|||||| ||.|...|.||..:.:.  |:|       .::..:|...||:
  Rat   578 ETVPAPP--------LPPPPPP-SAPPLPGTSSPTVVFNSGLADG-------PIKLFSVKIKKPI 626

  Fly   898 R-----PLY-WTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWT 956
            :     |:: |..:                            :|...||.            ::.
  Rat   627 KTKFRMPVFNWVAL----------------------------KPNQINGT------------VFN 651

  Fly   957 EIEETPL--D-NIDEFTELFSRQAIAPV----SKPKELKVKRAKSIKVLDPERSRNVGIIWRSLH 1014
            ||::..:  | |:|||.|:|..:|..|.    |..:::..|.:..:.:|:..|::|:.|..|...
  Rat   652 EIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKITQKGSSKVTLLEANRAKNLAITLRKAG 716

  Fly  1015 VPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDH---PEQFLLDISLI 1076
            ..:.||..||:..|...:.::.::.:.....||:|::.::.......||::   .::|::..|.|
  Rat   717 KSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKI 781

  Fly  1077 SMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRG 1141
            ....::::.:.|...|.||:.:|..:|..:...|..:..|:.||.:..|||.||||||  :.:||
  Rat   782 ERLMQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMN--SSKRG 844

  Fly  1142 QADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERAAQMDF 1206
            ...||.|..|..|.|.||.:...||||     ||:...||...  ::.|...|...||:||.:..
  Rat   845 AVYGFKLQSLDLLLDTKSTDRKQTLLH-----YISNVVKEKYQ--QVTLFYNELHYVEKAAAVSL 902

  Fly  1207 EEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLF 1271
            |.|...:.:|.:   |...|       .|...|....:.::||:...:..:.||.......:|.|
  Rat   903 ENVLLDVKELQR---GMDLT-------KREYTMHDHNTLLKEFILHNEGKLKKLQDDAKIAQDAF 957

  Fly  1272 LETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIE 1333
            .:.::::..:||.       ..|..||..:..|...:|...::      |||.||.:||.:|
  Rat   958 DDVVKYFGENPKT-------TPPSVFFPVFVRFVKAYKQAEEE------NELRKKQEQALME 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	102/442 (23%)
Fmnl2	XP_038962712.1	Drf_GBD	23..275	CDD:461886	23/133 (17%)
		Drf_FH3	278..475	CDD:461885	41/253 (16%)
		FH2	622..973	CDD:396655	96/416 (23%)