Protein Alignment capu and fmnl1

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 1136
• Identity: 237/1136 - (20%)
• Similarity: 411/1136 - (36%)
• Gaps: 317/1136 - (27%)

  Fly   377 TPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAASENV-EDDTAPLPLPPP 440
            :|...|:......|.....|..::|:.:      .:.||.:|::...:.|:: :..::|.|
 Frog   141 SPEVGGLDALVEYLSYAQGSCPIDTECS------DNGTPEKSKSLQRSLEDINKSSSSPSP---- 195

  Fly   441 PPGFGTPTTPLLSSNVLKK--VASFTVEKSSAGNNSSNPPNLC----------PTSDETTLLATP 493
                  ..||..|.|:..:  :.|.:..:::...|..:..::|          .:.....:..:.
 Frog   196 ------TNTPSRSRNLTARYNLHSRSTMRNTKHANMKDDVHVCIMCLRAIMNYQSGFSMVMSHSS 254

  Fly   494 CSSSLTVA-------TLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKF-----EGQML 546
            |.:.:|::       |....:.:.||...|.||           .:|..:|:..|     ||...
 Frog   255 CVNKITLSLSNKNPRTKALVLELLAAVCLVRGG-----------HELILSAFNYFMEMCGEGARF 308

  Fly   547 IKWLISTMQSNPKSSSGDANQELFNTLALQFCN-------NL----------------KYVGVLK 588
            .| |:...::.      |:|.: |....:||.|       |:                :|:.:||
 Frog   309 EK-LMEYFRTE------DSNID-FMVACMQFINIVVHSVKNMNFRVFLQYEFTLLGLDEYLEILK 365

  Fly   589 QISNEHLDCGFSPY------------------EMYQWT-----HTEQPTTSLPLTPGKLDKVAAW 630
            ...:|.|......|                  ||.:..     |..:.|..|.||..:..:..|.
 Frog   366 NTESERLQVQIQAYLDNIFDVNSLLEDTDTKNEMLEHVEDLQEHLTRVTEKLQLTENEYVRRVAE 430

  Fly   631 PFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLL-------NCT 688
            .........|.:.||.           ....:.......:..|:|  :::|:.:|       .||
 Frog   431 LEKQLDQCRREMSSAK-----------EKLVVQAPQVTQNIVQRT--ELVKRSVLWVEPAGDTCT 482

  Fly   689 TLAEVHAVVNELLSSVDEPPRRPSKRCVNL-------TELLNA---------------------- 724
            .....:...::|.|:...||..||...:.|       |:.|::
 Frog   483 EEISDNTFTSDLPSAASTPPLSPSAIRITLISPSVTSTDALSSRGNSPRSTTPPALLPSLPESSE 547

  Fly   725 ---------------SEATVYEYNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNES 774
                           |..|..:.:|........|..| :|||.:         .||.::..|..
 Frog   548 IFSIPAPSPVPSSEDSSDTALKASKVNPVPSPPSIID-QTQTSN---------AQSLSRTHDES- 601

  Fly   775 AKEDGEKPHAVAPPPPPPPPPLHAFVAPPPPPPPP----PPPPPPLANYGAPPPPPPPPPGSGSA 835
                         |||||||||.:....|||||.|    .||||||......|||||.|.|...|
 Frog   602 -------------PPPPPPPPLPSIAEIPPPPPLPMSADVPPPPPLPELSGIPPPPPLPMGEQGA 653

  Fly   836 PPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKP---- 896
            |||||..   |..|:||||||   .||  ...||| |.|..|......||    .|:..||
 Frog   654 PPPPPSM---GAPGVPPPPPP---PPS--GFGPAP-PPPPGGQPAATLNT----GVSIKKPIQTK 705

  Fly   897 --MRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEI- 958
              |:.|.|..:                            :|...||.            ::|.:
 Frog   706 LRMQVLNWVAL----------------------------KPTQINGT------------VFTHLN 730

  Fly   959 EETPLDNID--EFTELFSRQAIAPVSKPKELKVKRAKS----IKVLDPERSRNVGIIWRSLHVPS 1017
            :|..|..:|  :|.|.|..:|..|......:|||.|::    :.:::..|::|:.|..|...:..
 Frog   731 DEKVLQELDMSDFEENFKTKAQGPSQTTFSMKVKAAQNQPNKVSLIETNRAKNLAITLRKGGLSP 795

  Fly  1018 SEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDH---PEQFLLDISLISMA 1079
            ..|..||...|....:::.|:.::....|:.|.|:|........|||.   .::|::.:..|...
 Frog   796 EAITSAIQKYDMQAFNMDFLELLARFLPTDWERQQISRYCRDQKPLDDLTAEDRFMVHLCSIPRL 860

  Fly  1080 SERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQAD 1144
            :||::.:.|.|.|.:..:.|..:|:.:...|..:..|:.||.:..::|..|||||  :.:||.|.
 Frog   861 AERVNTMTFMANFPDMASRLKPQLDALIAASMSIKSSDKLKGILELVLAFGNYMN--SSKRGAAY 923

  Fly  1145 GFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERAAQMDFEEV 1209
            ||.|..|..|.:.||.:...||||:::|....:.........::..       :::||.:..:.|
 Frog   924 GFRLQSLDVLLETKSTDRKQTLLHYMIRVICEKYSHLSNFYCDLNF-------MDKAATVSLDSV 981

  Fly  1210 QQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSK-----MEEFVEGADKSMAKLHQSLDECRD 1269
            ...:               |.|.|...::.:.|..:     :::|::....|:.:|.......::
 Frog   982 LADV---------------KSLQAGMEQVQKEFTKQDDCLILKDFIKSNMDSLKQLSADAKTAQE 1031

  Fly  1270 LFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFK------DIWKKEITSLLNELMKKS- 1327
            .:...:.::..:.|.       ..|..||..:..|...:|      :.|||: .|.:.|...::
 Frog  1032 AYDAAVGYFGENAKT-------TPPSTFFPIFVRFIKAYKQAEQDLETWKKQ-ESAVQEAKPETA 1088

  Fly  1328 -KQAQ----IES-RRNVSTKVEKSGRISLKE 1352
             |||.    ::| |..|:...|.:.::..||
 Frog  1089 GKQAPQSPVVKSLRPQVNLMAELNKKLQTKE 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	90/453 (20%)
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:461886	23/157 (15%)
		Drf_FH3	286..>423	CDD:461885	29/155 (19%)
		FH2	698..1064	CDD:396655	86/436 (20%)