DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment capu and FAM47C

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001013758.1	Gene:	FAM47C / 442444	HGNCID:	25301	Length:	1035	Species:	Homo sapiens

Alignment Length:	1074	Identity:	223/1074 - (20%)
Similarity:	332/1074 - (30%)	Gaps:	316/1074 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 CSSNDSLFTDPVDELIISKHYLNTAAKEHNNPKAKRDRPLSEISVTSVDTLSP--NTAKAVLELQ 244
            |.|.:.......||.::.|..|.....:   ||:::.:.|.:.::.|  .|||  ...||.:|
Human    62 CQSPEDTLVCRRDEFLLPKISLRGPQAD---PKSRKKKLLKKAALFS--KLSPAQPARKAFVE-- 119

  Fly   245 KRCRADKLACLSLTRVTYLSIANDLQEVEEPDRASILHDTDLLVAPNSPAESSPD---EELMALQ 306
                                      |||    |.::....|.:.||...:..||   :.|..|.
Human   120 --------------------------EVE----AQLMTKHPLAMYPNLGEDMPPDLLLQVLKPLD 154

  Fly   307 LGKKLAQVLGSGAG------SPLTPGTMEPCAAGSGSPLANGELFNVSKAKKVELQNLSSRFTAA 365
            ..:||... ||..|      .|..||.. ||...|..|                   ..:|.:..
Human   155 PERKLEDA-GSCEGQEKTTDEPTEPGKY-PCGEFSPRP-------------------PETRVSCL 198

  Fly   366 VTQTPPGVTSS---TPNESGVT--GPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAAS 425
            ..:.|....||   .|.|:||:  .|..| ....||..||...|.:...:..  |.::|.:|...
Human   199 PPEPPKTPVSSLRPEPPETGVSHLRPQPP-KTQVSSLHLEPPETGVSHLRPE--PPKTQVSSLHL 260

  Fly   426 ENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVASFTVEKSSAGNNSSNPPNLCPTSDETTLL 490
            |..|...:.|.|.||    ||..:.|.......:|:....|....|     .|:||        |
Human   261 EPPETGVSHLYLEPP----GTGVSHLCPEPPKTRVSHLHREPPETG-----VPDLC--------L 308

  Fly   491 ATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYV-PEKLSFAAYEKFEGQMLIKWLISTM 554
            ..|.|   .|:.|.||              .|..|.|:: ||.              .|.|:|::
Human   309 EPPKS---RVSHLRPE--------------PSETGVSHLHPEP--------------PKTLVSSL 342

  Fly   555 QSNPKSSSGDANQELFNTLALQFCNN--LKYVGVLKQISNE----HLDCGFSPYEMYQWTHTEQP 613
            ...|.           .|.....|..  ...|..|:|:..|    || |            .|.|
Human   343 HPEPP-----------ETGVSHLCPEPPETRVSPLRQLPPEAGVSHL-C------------PEPP 383

  Fly   614 TTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLAS----LGAGGVAGSLATIATASTASSDNQK 674
            .|.:|....:..|....|....|...|.   ::|.|    :|             .|....:..|
Human   384 KTRVPPLRPETPKNGVSPLFPEPPKTRI---SNLRSEPPKIG-------------VSHLCLEPPK 432

  Fly   675 TLQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPR------RPSKRCVNLTEL-LNASEATVYEY 732
            |....|:                       .|||.      ||......::.| |...|..|...
Human   433 TRGSHLR-----------------------PEPPETGVSHLRPEPPKTRVSSLHLEPPETGVSHL 474

  Fly   733 NKTGAEGCVKSFTDAETQTESEDCEGTCKCGQ-SSTKVSDNESAKEDGEKPHAVAPPPP------ 790
            .....|..|     :..:.|..|...:..|.: ..|:||.......:....| :.|.||
Human   475 CPEPPEKDV-----SHLRPEPPDTGVSHLCPEPPKTRVSHLRPEPSETGVSH-LRPEPPKILVSS 533

  Fly   791 ---PPPPPLHAFVAPPPP--------PPPP--------PPPPPPLANYGAPPPP-------PPPP 829
               .||....:.:.|.||        |.||        |.||....::..|.||       ||.|
Human   534 LHQAPPESSVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPDTGVSHLCPEPPKTRVSSLPPEP 598

  Fly   830 PGSGSA---PPPP--------PPAPIEGGGGIPPPPPP-----------------MSASPSKTTI 866
            |.:|.:   |.||        |..|..|...:.|.||.                 :...|.||.:
Human   599 PETGVSHLCPEPPETRVSHLRPEPPETGVSHLRPEPPKTRMYSLRPEPPNTGVSHLCPEPPKTRV 663

  Fly   867 SPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSS 931
            |..| |:|.|....|......::.|:..:|..|......:...||..|..|:......:..|...
Human   664 SSLP-PEPPETGVSHLCPEPPETRVSHLRPEPPETGVSRLHPEPPKTRVSSLHAEPPESRVSHLC 727

  Fly   932 PDEPPAANGADAPPTAP-PATKEIWTEIEETPLDNI-DEFTELFSRQAIAPVSKPK-------EL 987
            | |||....:...|..| |....:..|..||.:.:: .|..|.........:.||:       ..
Human   728 P-EPPETGVSHLRPEPPKPRVSSLRPEPLETRVSHLRPEPPETGVSHLHPELPKPRVSSLHLEPP 791

  Fly   988 KVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQR 1052
            |.:|..|:::..|:..|...:........:|.::. ::...||          |.::...|.|||
Human   792 KTRRVSSLRLEPPKTGRVSSLCPEPTKTGASHLKE-LFQEGTS----------STMECVSDSLQR 845

  Fly  1053 IKEAAGGDIPLDHPEQFLLDISL---ISMASERISCIV-----FQAEFEESVTLLFRKLETVSQL 1109
                       .|..:.|.|...   :.:..|.||.:.     .:|.:::.......:..:..:.
Human   846 -----------RHTSRKLRDFKWAGDLGVNEESISSLFDFTPECRATYQDQKNKKANECSSGLKY 899

  Fly  1110 SQQLIESEDLKLVFSIILTL-GNYMNGGNRQRGQ 1142
            |.:|.|.:::|. ||....| |...|..|....|
Human   900 SMELDEMDEVKF-FSQEKDLDGKIQNAPNSHSAQ 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	53/273 (19%)
FAM47C	NP_001013758.1	FAM47	1..257	CDD:291315	56/255 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..797		166/780 (21%)
		FAM47	<365..509	CDD:291315	37/200 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930