DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and GRID2IP

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	1370	Identity:	267/1370 - (19%)
Similarity:	426/1370 - (31%)	Gaps:	510/1370 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EKSPPGGASLVRMGITGGGGA--------GEVGVALSERRGSRVRVLSRLMGQKRIREA------ 63
            ::.||..|||:..|:.|.|||        |......:.|....|.:.|.|.|......|
Human   256 DEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHGPVWIESVLPGSPADNAALKSGDR 320

  Fly    64 --FLHSPKLGSSSEVN----LQGAGNGSSDWIAAET-EVEHGQLDCSAEPADFHDVVSLDCTDSL 121
              ||:...:.:.|...    |||:|       |..| .||.|.:..:::            :|||
Human   321 ILFLNGLDMRNCSHDKVVSMLQGSG-------AMPTLVVEEGLVPFASD------------SDSL 366

  Fly   122 EYHNCSSDECCYASNDTLTERQNRELQQRQRQHHHHHHHIHNAHESHHHYPYDRRSLCTSCSSND 186
            :..|.||   ...|...:.|.....::.:.|.......|:..        |.:|..:|.:.   :
Human   367 DSPNPSS---ALTSLQWVAEILPSSIRVQGRTFSQQLEHLLT--------PPERYGVCRAL---E 417

  Fly   187 SLFTDPVDELIISKHYLNTAAKEHNNPKAKRDRPLSEISVTSVDTLSPNT-------AKAVL--- 241
            |.|                   :|.|                :|||..:.       ||.||
Human   418 SFF-------------------QHRN----------------IDTLIVDVYPVLDTPAKQVLWQF 447

  Fly   242 -------ELQKRCRADKLAC-LSLTRVTYLSIANDLQEVEEPDRASILHDTDLLVAPNSPAESSP 298
                   |.|:.|: :|:|| |..|.:|           .||:     .:.||...|.  .|..|
Human   448 IYQLLTYEEQELCQ-EKIACFLGYTAMT-----------AEPE-----PELDLESEPT--PEPQP 493

  Fly   299 DEELMALQLGKKLAQVLGSGAG------------SPLTPGTMEPCAAGSGSPLANGELFNVSKAK 351
            ...|.|..:.::..:..|..||            .||.||..:   ||.|:.|
Human   494 RSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQ---AGDGTSL------------ 543

  Fly   352 KVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPV 416
                                   ..|||..           ..|:...|.:|.:..|||.....|
Human   544 -----------------------PETPNPK-----------MMSAVYAELESRLNSSFKGKMGTV 574

  Fly   417 QSQTNSAASENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVASFTVEKSSAGNNSSNPPNLC 481
               :.|.||             ||.|.....|.|...|.|     |:..|:
Human   575 ---SKSRAS-------------PPGPSPAVTTGPRTLSGV-----SWPSER-------------- 604

  Fly   482 PTSDETTLLATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQML 546
                   ||.:||...|             .:||:|..:.|
Human   605 -------LLPSPCYHPL-------------CSGGLASPSSS------------------------ 625

  Fly   547 IKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTE 611
                    :|:|.:|                                 ||...:|        :.
Human   626 --------ESHPYAS---------------------------------LDSSRAP--------SP 641

  Fly   612 QPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTL 676
            ||... |:.|.....    |..:.|...|.|.:.|                  ....|.|..:.|
Human   642 QPGPG-PICPDSPPS----PDPTRPPSRRKLFTFS------------------HPVRSRDTDRFL 683

  Fly   677 QQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEYNKTGAEGCV 741
             .:|.::|....|      :|::.|:..:                         :|.:.......
Human   684 -DVLSEQLGPRVT------IVDDFLTPEN-------------------------DYEEMSFHDDQ 716

  Fly   742 KSFTDAETQTESEDCEGTCKCGQSST--KVSDNESAKEDGEKPHAVAPPP--PPPPPPLHAFVAP 802
            .||...| ::.:.||..:.:.|.|.|  .:||:            :.|||  |||||||....|.
Human   717 GSFVTNE-RSSASDCISSSEEGSSLTYSSISDH------------IPPPPLSPPPPPPLPFHDAK 768

  Fly   803 PPPPP------PPPPPPPPLANYGAPPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMSASP 861
            |....      |......||.....|.|||||||    .|||.|.||
Human   769 PSSRSSDGSRGPAQALAKPLTQLSHPVPPPPPPP----LPPPVPCAP------------------ 811

  Fly   862 SKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTE 926
                      |..:.|....|:.|...|       ::.|.|.::                    |
Human   812 ----------PMLSRGLGHRRSETSHMS-------VKRLRWEQV--------------------E 839

  Fly   927 NSGSSPDEPPAANGADAPPTAPPATKEIWTEI-EETPLDNIDEFTEL------FSRQAIA-PVSK 983
            ||..:                      ||.:: |::..|.:.:..:.      |..|..| ||..
Human   840 NSEGT----------------------IWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPAKPVPG 882

  Fly   984 PKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATED 1048
            |:..:.|..  :::|..:::.|..|:...|.:..:|:...:..::...:....|..:.......|
Human   883 PEPFRKKEV--VEILSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDAD 945

  Fly  1049 ELQR---IKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLS 1110
            |.||   .:||.|   .|..|:||:|.:..:.....|:..:.|||..:|....:...||.:.|.|
Human   946 EEQRYQAFREAPG---RLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQAS 1007

  Fly  1111 QQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYI 1175
            .:|..|..|..:...:|.:|||:|.|..:..:..||.::.|.:|...|:.:..:|.||.:.:: :
Human  1008 LELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKS-L 1071

  Fly  1176 AQRRKEGVHPLEIRLPIPEPADV-ERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIM 1239
            :|...|.:...:....:|..|.| :||...|..::...|.::..   .|:..:        |...
Human  1072 SQHFPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQD---ACQSIS--------PSSE 1125

  Fly  1240 EPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNF 1304
            :.|...|..|:|.|..::..|.....|..:...:.:.|:....||       .|.:.||..:..|
Human  1126 DKFAMVMSSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKA-------TTSEAFFGIFAEF 1183

  Fly  1305 TNDFK 1309
            .:.|:
Human  1184 MSKFE 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	87/434 (20%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		5/12 (42%)
		PDZ_signaling	278..353	CDD:238492	16/81 (20%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	22/125 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		10/61 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		18/149 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		23/77 (30%)
		FH2	820..1188	CDD:280362	88/440 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810