DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and FMN1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001264242.1	Gene:	FMN1 / 342184	HGNCID:	3768	Length:	1419	Species:	Homo sapiens

Alignment Length:	1471	Identity:	379/1471 - (25%)
Similarity:	579/1471 - (39%)	Gaps:	385/1471 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SERRGSRVRVLSRLMGQKRIREAFLHSPKLGSSSEVNLQGAGNGSSDWIAAE--TEVEHGQLDCS 103
            ::|:|...|..:.|||:.:|..:  ||..| |.:..||         |:..|  ..:.:|.|.||
Human   177 TKRKGRGGRESAPLMGKDKICSS--HSLPL-SRTRPNL---------WVLEEKGNLLPNGALACS 229

  Fly   104 AE-----PADFHDVVSLDC-TDSLEY-------------HNCSSDECCYASNDTLTERQNRELQQ 149
            .:     |.|.......|. ..|.|.             .:|||.|   |..|.: .|....|:.
Human   230 LQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPDCSSTE---AGGDGI-RRPPSGLEH 290

  Fly   150 RQRQHHHHHHHIHNAHESHHHYPYDRRSLCTSCSSNDSLFTDPVDELIISKHYLNTAAKEHNNPK 214
            :|.          ...|||.                     ||      .||  ..|.|:.....
Human   291 QQT----------GLSESHQ---------------------DP------EKH--PEAEKDEMEKP 316

  Fly   215 AKR---DRPLSEISVTSVDTLSPNTAKAVLELQKRCRADKLACLSLTRVTYLSIANDLQEVEEPD 276
            |||   .:|:|:: |..|..||....:.|....|                    ..:...:....
Human   317 AKRTCKQKPVSKV-VAKVQDLSSQVQRVVKTHSK--------------------GKETIAIRPAA 360

  Fly   277 RASILHDTDLLVAPNSPAESSPDEELMALQLGKKLAQVLGSGAGSPLTPGTMEPCAAGSGSPLAN 341
            .|..:...|||..|.:.|.:.........:.|.:.:|   |.||...:..::...|.|:    .|
Human   361 HAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQ---SPAGETASISSVSASAEGA----VN 418

  Fly   342 GELFNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAG-----------PLGATTS 395
            .....|.:::|::......|....|..:.|.....|.|:.....|.|           .:|..:|
Human   419 KVPLKVIESEKLDEAPEGKRLGFPVHTSVPHTRPETRNKRRAGLPLGGHKSLFLDLPHKVGPDSS 483

  Fly   396 SPSLETQSTVIISFKSSQTPVQSQ-----TNSAASENVEDDTAPLPLPPPPPGFGTPTTPLLSS- 454
            .|..:.        |....|..:.     .|||:..:....|:|:|         :|.:|.|.|
Human   484 QPRGDK--------KKPSPPAPAALGKVFNNSASQSSTHKQTSPVP---------SPLSPRLPSP 531

  Fly   455 ---NVLKKVASFTVEKSSAGNNSSNPPNLCPTSDETTLLATPC------SSSLTVATLPPEIAVG 510
               :.:.::.:...|:.:|.|:|                  ||      |..::..||.|..:..
Human   532 QQHHRILRLPALPGEREAALNDS------------------PCRKSRVFSGCVSADTLEPPSSAK 578

  Fly   511 AAAGGVAGGAGSRRGS-SYVPEKLSFAAYEKFEGQMLIKWL-------ISTMQSNPKSSSGDANQ 567
            ......|..|..|.|. ..||            |:.|.|.|       ....||.|..||.....
Human   579 VTETKGASPAFLRAGQPRLVP------------GETLEKSLGPGKTTAEPQHQSPPGISSEGFPW 631

  Fly   568 ELFNTLALQFCNN-------LKY---------VGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTS 616
            :.||....:...|       |.|         :...::.||..        |:|...|.:...|.
Human   632 DGFNEQTPKDLPNRDGGAWVLGYRAGPACPFLLHEEREKSNRS--------ELYLDLHPDHSLTE 688

  Fly   617 L-PLTPGKLDKVAAWPFSSTPS-----GIRALESASLASLGAGGVAGSLATIATASTASSDNQKT 675
            . ..|||:|.  |.||...|..     |::..|:...|::               .....::::.
Human   689 QDDRTPGRLQ--AVWPPPKTKDTEEKVGLKYTEAEYQAAI---------------LHLKREHKEE 736

  Fly   676 LQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEYNKTGAEGC 740
            ::.:..:..|....:...||::...|....|          ||...|        |:...|  ||
Human   737 IENLQAQFELRAFHIRGEHAMITARLEETIE----------NLKHEL--------EHRWRG--GC 781

  Fly   741 ---------------VKSFTDAETQTESE----DCEGTCKCGQSSTKVS--------DNESAKED 778
                           .|:|.:...||:.|    .||...|..:|:..|.        ...|...|
Human   782 EERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLVPKKLNISSLSQLSPPND 846

  Fly   779 GEKPHA--------------VAPPPP---PPPPPLHA---FVAPPPPPPP----PPPPPPPLANY 819
            .:..||              ..||||   ||||||.:   .::|.||.||    ||.||||
Human   847 HKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPP---- 907

  Fly   820 GAPPPPPPPPPGSGSAPPPPPPAPIEGG------GGIPPPPPPMSASPSKTTISPAPLPDPAEGN 878
              |||||.|||.|...||||||.|:...      ||.||.|||           |...|.|..|.
Human   908 --PPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPP-----------PGLAPPPPPGL 959

  Fly   879 WF----HRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAAN 939
            :|    ..:...||.|:.|..||:|||||||..|              |.::|
Human   960 FFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQIS--------------DRSQN------------ 998

  Fly   940 GADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSR----QAIAPVSKPKELKVKRAKSIKVLDP 1000
                      ||..:|..:||..:.:..||..|||:    |...|:|:..|.|.|..|.||:||.
Human   999 ----------ATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDG 1053

  Fly  1001 ERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKE----AAGGDI 1061
            :||:.|||:..|||:...:|:.||:::|.|||.||.|..:...:|.||||.:|::    :...::
Human  1054 KRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEEL 1118

  Fly  1062 P-LDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSI 1125
            . ||.|||||.:::.|...:||..||:|::.|.|.:|.|.||:|.:::.|:.|:..:.:|.:.::
Human  1119 KLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILAL 1183

  Fly  1126 ILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRL 1190
            ||..|||||||||.||||||::|:||.|||||||:::...|:.::|:.|:....:|......: .
Human  1184 ILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSV-F 1247

  Fly  1191 PIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADK 1255
            |:|||.|...|:|:.||::.:.:..|.::....::....|...|..|.::|||.|:|||.:.|.|
Human  1248 PLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKK 1312

  Fly  1256 SMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLL 1320
            ........|:..:..|..|:|::...||:..   .:.||...|..|..|.:|||.|||:|..::.
Human  1313 EHKMEESHLENAQKSFETTVRYFGMKPKSGE---KEITPSYVFMVWYEFCSDFKTIWKRESKNIS 1374

  Fly  1321 NELMKKSKQ--AQIESRRNVSTKVEKSGRISLKERMLMRRS 1359
            .|.:|.:::  :::.|.:.|.|| :.:...|||||:..:.:
Human  1375 KERLKMAQESVSKLTSEKKVETK-KINPTASLKERLRQKEA 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	153/435 (35%)
FMN1	NP_001264242.1	Microtubule-binding. /evidence=ECO:0000250	1..622		113/574 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..194		6/16 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..331		23/112 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..641		67/371 (18%)
		Mediates interaction with alpha-catenin. /evidence=ECO:0000250	456..842		87/477 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..711		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..978		52/135 (39%)
		FH2	973..1370	CDD:214697	153/436 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1390..1419		9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2067
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002764
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104364
Panther	1	1.100	-	-	LDO	PTHR13037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4961
SonicParanoid	1	1.000	-	-		X2588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.800