DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and fus1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_594737.1	Gene:	fus1 / 2541741	PomBaseID:	SPAC20G4.02c	Length:	1372	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	116/583 - (19%)
Similarity:	216/583 - (37%)	Gaps:	163/583 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 PPPAPIEGGGGIPPPPPPMSASPS--------------KTTISPAPLP--------DPAEGNWFH 881
            |||||      :|||.||:..:.|              ||.|.|..:.        ..:|...:
pombe   806 PPPAP------LPPPAPPLPTAMSSLQKFEKNDSQIFRKTIIIPENISIDDIFKFCSGSESEVY- 863

  Fly   882 RTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPP- 945
             .:.:.....||.|.::.|:|.|:                        ..|.|....|...|.|
pombe   864 -ASKIPGELCNPSKRLKQLHWKRL------------------------EVPFEKTLWNIVVADPY 903

  Fly   946 --TAPPATKEIWTEIEET-PLDNIDEFTELFSRQAIAPVSKPKELKVKRAKSIKVLDPERSRNVG 1007
              |.....:.|:.::|:. ||..:             .||..   |||.......:|.::..::
pombe   904 LLTLKLTAEGIFKQLEDCYPLREV-------------TVSNK---KVKEYTGFMPVDLQQMVSI- 951

  Fly  1008 IIWRSLHVPSS----EIEHAIYHIDTSVVSL------------EALQ-----HMSNIQATEDELQ 1051
                .||..:|    ||....:|.|..::.|            |.|:     :||   :..:|:.
pombe   952 ----RLHRFNSLTPIEIAKKFFHCDHDIMELVDFFNDRKFFRQEGLKKQLKPYMS---SRNEEVM 1009

  Fly  1052 RIKEAAGGDIPLDHPEQF--LLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLI 1114
            .:.|..   :.|...:|.  |:.:.:.:...:|::.:..::....:.....|::..:...|.:|.
pombe  1010 EVSEKL---LELSRFDQIYTLIVVDIDTYYEKRMAALKIKSFLANNFRDFRRQIRKLHCASLELK 1071

  Fly  1115 ESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHF---IVRTYIA 1176
            .|...|...:::|.:||:||...|   :|.|:.|:.|.:...:|:.::..||||.   ||||:..
pombe  1072 SSLHFKYFLNLVLHIGNFMNDAPR---RAKGYRLESLLRASMIKNDKTGLTLLHTIEKIVRTHFP 1133

  Fly  1177 QRRKEGVHPLEIRL----PIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPE 1237
            |        ||..|    .|||      .::.:.|:::|...|:.::....::..:.....|..:
pombe  1134 Q--------LEAFLVDLKAIPE------ISRFNLEQLEQDCNDICERMKNVEKDFSNEGIFSNHK 1184

  Fly  1238 IMEPFKSKMEEFVE--GADKSMA-KLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFE 1299
            .:.|.....|..|.  .:.|||. :|:..:.|.:.....|:..|..:|...|.:
pombe  1185 ALHPDDHICEVMVPWIPSGKSMVDELNSDITELKTTLKTTLLMYGENPDEPTSS----------- 1238

  Fly  1300 YWTNFTNDFKDI---WKKEITSLLNELMKKSKQ----------AQIESRRNVSTKVEKSGRIS 1349
              ..|.|:..:|   :||  .|.:|:.|:|.::          |.::|....::...|:..:|
pombe  1239 --ARFFNNLNEIILEYKK--ASTVNQKMEKEEELAFLRLQALKASVKSNNAENSGSSKNEEVS 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	91/466 (20%)
fus1	NP_594737.1	Drf_GBD	108..296	CDD:283920
fus1	NP_594737.1	FH2	868..1253	CDD:280362	90/465 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900