Protein Alignment capu and DAAM1

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_055807.1
• Gene: DAAM1 / 23002
• HGNCID: 18142
• Length: 1078
• Species: Homo sapiens
• Alignment Length: 1186
• Identity: 268/1186 - (22%)
• Similarity: 437/1186 - (36%)
• Gaps: 320/1186 - (26%)

  Fly   327 TMEPCAAGSGSPLANGELFNVSKAKKVELQNLSSRFTAAVTQTPPG-----VTSSTPNESGVTGP 386
            ||||..     |:...|..:|..::.|:..:|:.:...|:...|..     ..|...::....|
Human    40 TMEPAL-----PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKG- 98

  Fly   387 AGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAASENVED-DTAPLPLPPPPPGFGTPTTP 450
                  .||.|.........::.:.|...::.:.....|:.:|. .||   |...|..|.|....
Human    99 ------ATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTA---LRTKPMRFVTRFID 154

  Fly   451 L--LSS--NVLK----KVASFTVEKSSAG------NNSSNPPNLCPTSDETTLLATPCSSSLTVA 501
            |  ||.  |.||    :.:...:..|..|      |||....::...|:...::|    .||:..
Human   155 LDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIA----QSLSTE 215

  Fly   502 TLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAY--EKFEGQMLIKWL-ISTMQSNPKSSSG 563
            .:..::||....|.|....|..:  ..:...|.:..|  |:...|.||..| .||.:...:.|..
Human   216 NIKTKVAVLEILGAVCLVPGGHK--KVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLK 278

  Fly   564 DANQELFNTL--------ALQFCNNLKY----VGV------LKQISNEHLDCGFSPYEM------ 604
            .|.....|.:        :|.|..:|:|    :|:      |::..|..||.....:||
Human   279 TAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDE 343

  Fly   605 ------YQWTH--TEQPTTSLPLTPGKLDKVAAWP-FSSTPSGIRALESASLASLGAGGVAGSLA 660
                  ::..|  |:..|....||..:|....|:| |.|.                       |.
Human   344 LEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSI-----------------------LH 385

  Fly   661 TIATASTASSDN--------QKTLQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRR--PSKRC 715
            .........|.|        .:.:|||:               :.|:.....|..|..  ..|..
Human   386 HCLQMPYKRSGNTVQYWLLLDRIIQQIV---------------IQNDKGQDPDSTPLENFNIKNV 435

  Fly   716 VNLTELLNASEATVYEYNKTGAEGCVKSFTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGE 780
            |.:  |:|.:|...:   |..||...|...:.:.:.|.::.|...|..:....:......||..|
Human   436 VRM--LVNENEVKQW---KEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLE 495

  Fly   781 KP------------------H--------AVAPPPPPPPPPLHAFVAPPPPPPPPPPPPPPLANY 819
            |.                  |        |..|..|.|..|...|.:..|....||||||||...
Human   496 KETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGG 560

  Fly   820 GAPPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTN 884
            ..||||||.|||.    |||||.|...|..:|||..||..:..|
Human   561 MLPPPPPPLPPGG----PPPPPGPPPLGAIMPPPGAPMGLALKK--------------------- 600

  Fly   885 TMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPP 949
               ||...|...::...|:::          |.  |..:.|
Human   601 ---KSIPQPTNALKSFNWSKL----------PE--NKLEGT------------------------ 626

  Fly   950 ATKEIWTEIEET------PLDNIDEFTELFSRQA---IAPVSKPKE-----------LKVKRAKS 994
                :||||::|      .|::::.....:.||.   :...||.||           |||   |.
Human   627 ----VWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKV---KE 684

  Fly   995 IKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTS--------VVSLEALQHMSNIQATED--- 1048
            :.|:|..|::|..|:...|.:.:.||:.||..:|..        ...|:.:...|:|...|:
Human   685 LSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKH 749

  Fly  1049 ELQRIKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQL 1113
            ||.|:.:|          ::||.::|.|:...:|:..:.|:.:|.|.|..:..|:|.:...|:::
Human   750 ELDRMAKA----------DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEV 804

  Fly  1114 IESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSK-ESHTTLLHFIVRTYIAQ 1177
            ..|..||.:..::|..|||||.|  |||.|.||.:..|.|:.|.||. :.:.||||::: |.:
Human   805 FRSGALKQLLEVVLAFGNYMNKG--QRGNAYGFKISSLNKIADTKSSIDKNITLLHYLI-TIV-- 864

  Fly  1178 RRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPF 1242
               |..:|..:.|. .|..|:.:||:::..|:.::|..| :..|....|..:...:..|:..:.|
Human   865 ---ENKYPSVLNLN-EELRDIPQAAKVNMTELDKEISTL-RSGLKAVETELEYQKSQPPQPGDKF 924

  Fly  1243 KSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTND 1307
            .|.:.:|:..|..|.:.:...|.|.:|||.:.::  ||..:|     .:..||:||..:..|...
Human   925 VSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVK--HFGEEA-----GKIQPDEFFGIFDQFLQA 982

  Fly  1308 FKDIWKKEITSLLNELMKKSK---------QAQIESRRNVSTKVEK------------------- 1344
            ..:. |:|     ||.|:|.|         :||::.:|....|:.|
Human   983 VSEA-KQE-----NENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALR 1041

  Fly  1345 SGRISLKERMLMRRSK 1360
            ||.:..|:...::|::
Human  1042 SGEVFDKDLSKLKRNR 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	112/458 (24%)
DAAM1	NP_055807.1	Drf_GBD	45..232	CDD:461886	40/205 (20%)
		Drf_FH3	235..439	CDD:461885	45/245 (18%)
		PRK12704	444..>513	CDD:237177	12/71 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..480		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..585		30/64 (47%)
		FH2	600..984	CDD:396655	112/477 (23%)
		Actin-binding	693..702		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	987..1034		12/51 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1055..1078		1/3 (33%)